Slc39a8 - solute carrier family 39 member 8 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-02
Description
Please note that currently there is no data available in PubChem associated with Slc39a8 - solute carrier family 39 member 8 (Norway rat). However, annotations from external sources are available.
Enables zinc:bicarbonate symporter activity. Involved in monoatomic cation transmembrane transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIn. Orthologous to human SLC39A8 (solute carrier family 39 member 8).
- metal cation symporter ZIP8
- ZIP-8
- solute carrier family 39 (metal ion transporter), member 8
- solute carrier family 39 (zinc transporter), member 8
- zinc transporter ZIP8
- zrt- and Irt-like protein 8
- SLC39A8 (human)
- SLC39A8 (black-footed ferret)
- SLC39A8 (European mink)
- SLC39A8 (Ahaetulla prasina)
- SLC39A8 (red-backed fairy wren)
- SLC39A8 (Oenanthe melanoleuca)
- SLC39A8 (Chinese forest musk deer)
- SLC39A8 (raccoon dog)
- SLC39A8 (Leopard gecko)
- SLC39A8 (Pteronotus mesoamericanus)
- SLC39A8 (black-legged kittiwake)
- SLC39A8 (Aeolian wall lizard)
- SLC39A8 (graceful crag lizard)
- SLC39A8 (lesser prairie-chicken)
- SLC39A8 (takin)
- SLC39A8 (yellow-footed antechinus)
- SLC39A8 (California condor)
- SLC39A8 (Macaca thibetana thibetana)
- SLC39A8 (Northern goshawk)
- SLC39A8 (snow leopard)
- SLC39A8 (rock ptarmigan)
- SLC39A8 (Loggerhead turtle)
- SLC39A8 (Sphaerodactylus townsendi)
- SLC39A8 (Eurasian river otter)
- SLC39A8 (bobcat)
- SLC39A8 (greater spear-nosed bat)
- SLC39A8 (American black bear)
- SLC39A8 (Ring-tailed lemur)
- SLC39A8 (Agile Gracile Mouse Opossum)
- SLC39A8 (Komodo dragon)
- SLC39A8 (American mink)
- SLC39A8 (leopard cat)
- SLC39A8 (elk)
- SLC39A8 (fence lizard)
- SLC39A8 (Arctic fox)
- SLC39A8 (rufous-necked snowfinch)
- SLC39A8 (white-rumped snowfinch)
- SLC39A8 (jaguarundi)
- SLC39A8 (common toad)
- SLC39A8 (common frog)
- SLC39A8 (scimitar-horned oryx)
- SLC39A8 (Barn swallow)
- SLC39A8 (Indian flying fox)
- SLC39A8 (Eurasian tree sparrow)
- SLC39A8 (Reeves's turtle)
- SLC39A8 (Tiger rattlesnake)
- SLC39A8 (striped hyena)
- SLC39A8 (leatherback sea turtle)
- SLC39A8 (Iberian mole)
- SLC39A8 (Jamaican fruit-eating bat)
- SLC39A8 (Sturnira hondurensis)
- SLC39A8 (Kuhl's pipistrelle)
- SLC39A8 (Myotis myotis)
- SLC39A8 (Pallas's mastiff bat)
- SLC39A8 (black swan)
- SLC39A8 (common lizard)
- SLC39A8 (Southern elephant seal)
- SLC39A8 (Trachemys scripta elegans)
- SLC39A8 (Pantherophis guttatus)
- SLC39A8 (Gabon caecilian)
- SLC39A8 (Francois's langur)
- SLC39A8 (greater horseshoe bat)
- SLC39A8 (Abingdon island giant tortoise)
- SLC39A8 (vaquita)
- SLC39A8 (tufted duck)
- SLC39A8 (silvery gibbon)
- SLC39A8 (ring-necked pheasant)
- SLC39A8 (Kakapo)
- SLC39A8 (Microcaecilia unicolor)
- SLC39A8 (Aquila chrysaetos chrysaetos)
- SLC39A8 (Common wall lizard)
- SLC39A8 (pale spear-nosed bat)
- SLC39A8 (Steller sea lion)
- SLC39A8 (willow flycatcher)
- SLC39A8 (California sea lion)
- SLC39A8 (burrowing owl)
- SLC39A8 (eastern brown snake)
- SLC39A8 (mainland tiger snake)
- SLC39A8 (brown bear)
- SLC39A8 (emu)
- SLC39A8 (Okarito brown kiwi)
- SLC39A8 (Nothoprocta perdicaria)
- SLC39A8 (red fox)
- SLC39A8 (puma)
- SLC39A8 (dingo)
- SLC39A8 (gelada)
- SLC39A8 (Yangtze finless porpoise)
- SLC39A8 (common vampire bat)
- SLC39A8 (blue tit)
- SLC39A8 (Ugandan red Colobus)
- SLC39A8 (beluga whale)
- SLC39A8 (northern sea otter)
- SLC39A8 (Hawaiian monk seal)
- SLC39A8 (white-rumped munia)
- SLC39A8 (helmeted guineafowl)
- SLC39A8 (koala)
- SLC39A8 (central bearded dragon)
- SLC39A8 (zebu cattle)
- SLC39A8 (great roundleaf bat)
- SLC39A8 (Australian saltwater crocodile)
- SLC39A8 (Gharial)
- SLC39A8 (leopard)
- SLC39A8 (Nanorana parkeri)
- SLC39A8 (black snub-nosed monkey)
- SLC39A8 (Malayan pangolin)
- SLC39A8 (Panamanian white-faced capuchin)
- SLC39A8 (Miniopterus natalensis)
- SLC39A8 (Egyptian rousette)
- SLC39A8 (Japanese quail)
- SLC39A8 (Taiwan habu)
- SLC39A8 (Great Tit)
- SLC39A8 (Gekko japonicus)
- SLC39A8 (cheetah)
- SLC39A8 (Common starling)
- SLC39A8 (ass)
- SLC39A8 (Thamnophis sirtalis)
- SLC39A8 (North Island brown kiwi)
- SLC39A8 (Swan goose)
- SLC39A8 (gray mouse lemur)
- SLC39A8 (Coquerel's sifaka)
- SLC39A8 (sooty mangabey)
- SLC39A8 (drill)
- SLC39A8 (Colobus angolensis palliatus)
- SLC39A8 (pig-tailed macaque)
- SLC39A8 (large flying fox)
- SLC39A8 (Arabian camel)
- SLC39A8 (Bactrian camel)
- SLC39A8 (Bison bison bison)
- SLC39A8 (bald eagle)
- SLC39A8 (Corvus cornix cornix)
- SLC39A8 (golden snub-nosed monkey)
- SLC39A8 (East African grey crowned-crane)
- SLC39A8 (White-tailed tropicbird)
- SLC39A8 (white-throated tinamou)
- SLC39A8 (speckled mousebird)
- SLC39A8 (brown roatelo)
- SLC39A8 (chuck-will's-widow)
- SLC39A8 (sunbittern)
- SLC39A8 (Buceros rhinoceros silvestris)
- SLC39A8 (yellow-throated sandgrouse)
- SLC39A8 (Kea)
- SLC39A8 (chimney swift)
- SLC39A8 (red-crested turaco)
- SLC39A8 (common barn owl)
- SLC39A8 (cuckoo roller)
- SLC39A8 (hoatzin)
- SLC39A8 (white-tailed eagle)
- SLC39A8 (Downy woodpecker)
- SLC39A8 (killdeer)
- SLC39A8 (bar-tailed trogon)
- SLC39A8 (red-throated loon)
- SLC39A8 (Red-legged seriema)
- SLC39A8 (African ostrich)
- SLC39A8 (little egret)
- SLC39A8 (Northern fulmar)
- SLC39A8 (common cuckoo)
- SLC39A8 (great cormorant)
- SLC39A8 (Dalmatian pelican)
- SLC39A8 (crested ibis)
- SLC39A8 (Adelie penguin)
- SLC39A8 (emperor penguin)
- SLC39A8 (Common canary)
- SLC39A8 (rifleman)
- SLC39A8 (carmine bee-eater)
- SLC39A8 (polar bear)
- SLC39A8 (American crow)
- SLC39A8 (Sunda flying lemur)
- SLC39A8 (Przewalski's horse)
- SLC39A8 (big brown bat)
- SLC39A8 (Philippine tarsier)
- SLC39A8 (green monkey)
- SLC39A8 (Yangtze River dolphin)
- SLC39A8 (Burmese python)
- SLC39A8 (minke whale)
- SLC39A8 (sperm whale)
- SLC39A8 (tiger)
- SLC39A8 (Green sea turtle)
- SLC39A8 (black flying fox)
- SLC39A8 (Myotis davidii)
- SLC39A8 (Weddell seal)
- SLC39A8 (American alligator)
- SLC39A8 (alpaca)
- SLC39A8 (Wild Bactrian camel)
- SLC39A8 (Chinese tree shrew)
- SLC39A8 (Chinese soft-shelled turtle)
- SLC39A8 (little brown bat)
- SLC39A8 (water buffalo)
- SLC39A8 (Chinese alligator)
- SLC39A8 (wild yak)
- SLC39A8 (Brandt's bat)
- SLC39A8 (goat)
- SLC39A8 (crab-eating macaque)
- SLC39A8 (Tibetan ground-tit)
- SLC39A8 (rock pigeon)
- SLC39A8 (white-throated sparrow)
- SLC39A8 (Saker falcon)
- SLC39A8 (medium ground-finch)
- Slc39a8 (long-tailed chinchilla)
- SLC39A8 (western painted turtle)
- SLC39A8 (peregrine falcon)
- SLC39A8 (Collared flycatcher)
- SLC39A8 (mallard)
- SLC39A8 (domestic ferret)
- SLC39A8 (small Madagascar hedgehog)
- SLC39A8 (European shrew)
- SLC39A8 (American pika)
- SLC39A8 (nine-banded armadillo)
- SLC39A8 (Pacific walrus)
- SLC39A8 (killer whale)
- SLC39A8 (western lowland gorilla)
- SLC39A8 (sheep)
- SLC39A8 (domestic cat)
- SLC39A8 (Bolivian squirrel monkey)
- SLC39A8 (olive baboon)
- SLC39A8 (pygmy chimpanzee)
- SLC39A8 (small-eared galago)
- SLC39A8 (Tasmanian devil)
- SLC39A8 (African savanna elephant)
- SLC39A8 (northern white-cheeked gibbon)
- SLC39A8 (turkey)
- SLC39A8 (pig)
- slc39a8 (tropical clawed frog)
- SLC39A8 (giant panda)
- SLC39A8 (white-tufted-ear marmoset)
- SLC39A8 (rabbit)
- SLC39A8 (zebra finch)
- SLC39A8 (Sumatran orangutan)
- SLC39A8 (platypus)
- SLC39A8 (horse)
- SLC39A8 (gray short-tailed opossum)
- SLC39A8 (Rhesus monkey)
- SLC39A8 (domestic cattle)
- SLC39A8 (dog)
- SLC39A8 (chimpanzee)
- SLC39A8 (chicken)
- Slc39a8 (house mouse)
Electroneutral divalent metal cation:bicarbonate symporter of the plasma membrane mediating the cellular uptake of zinc and manganese, two divalent metal cations important for development, tissue homeostasis and immunity (PMID: 22898811). Transports an electroneutral complex composed of a divalent metal cation and two bicarbonate anions or alternatively a bicarbonate and a selenite anion (PMID: 22898811). Thereby, it also contributes to the cellular uptake of selenium, an essential trace metal and micronutrient (PMID: 22898811). Also imports cadmium a non-essential metal which is cytotoxic and carcinogenic (PMID: 22898811). May also transport iron and cobalt through membranes (PMID: 22898811). Through zinc import, indirectly regulates the metal-dependent transcription factor MTF1 and the expression of some metalloproteases involved in cartilage catabolism and also probably heart development. Also indirectly regulates the expression of proteins involved in cell morphology and cytoskeleton organization. Indirectly controls innate immune function and inflammatory response by regulating zinc cellular uptake which in turn modulates the expression of genes specific of these processes. Protects, for instance, cells from injury and death at the onset of inflammation (By similarity). By regulating zinc influx into monocytes also directly modulates their adhesion to endothelial cells and arteries (By similarity). Reclaims manganese from the bile at the apical membrane of hepatocytes, thereby regulating the activity of the manganese-dependent enzymes through the systemic levels of the nutrient. Also participates in manganese reabsorption in the proximal tubule of the kidney. By mediating the extracellular uptake of manganese by cells of the blood-brain barrier, may also play a role in the transport of the micronutrient to the brain. With manganese cellular uptake also participates in mitochondrial proper function (By similarity). Finally, also probably functions intracellularly, translocating zinc from lysosome to cytosol to indirectly enhance the expression of specific genes during TCR-mediated T cell activation (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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