LAT - linker for activation of T cells (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-02
Description
The protein encoded by the LAT gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Enables molecular condensate scaffold activity; protein kinase binding activity; and signaling receptor complex adaptor activity. Involved in several processes, including cell surface receptor signaling pathway; intracellular signaling cassette; and membrane raft distribution. Located in Golgi apparatus and immunological synapse. Is active in TCR signalosome and plasma membrane. Implicated in immunodeficiency 52.
- IMD52
- LAT1
- pp36
- linker for activation of T-cells family member 1
- 36 kDa phospho-tyrosine adapter protein
- 36 kDa phospho-tyrosine adaptor protein
- 36 kDa phosphotyrosine adapter protein
- linker for activation of T cells, transmembrane adaptor
- p36-38
Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development (PMID: 23514740, PMID: 25907557). Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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