Asip - agouti signaling protein (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2024-12-13
Description
This gene is involved in hair pigmentation. In several strains (ACI, IS, LEA, LEC, NER, and WKAH) this gene encodes a functional protein while in others (BN, BUF, DON, F344, SD, SHR, TM, WKY, and WTC) it lacks a 19 nt indel and is non-protein coding. [provided by RefSeq, Apr 2015]
Predicted to enable neuropeptide hormone activity; type 3 melanocortin receptor binding activity; and type 4 melanocortin receptor binding activity. Predicted to be involved in melanin biosynthetic process and melanosome organization. Predicted to act upstream of or within several processes, including adult feeding behavior; epigenetic programming in the zygotic pronuclei; and melanosome transport. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in pigmentation disease and type 2 diabetes mellitus. Orthologous to human ASIP (agouti signaling protein).
- ASP
- agouti-signaling protein
- Agouti (coat color)
- agouti switch protein
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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- STRING: functional protein association networks
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