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Asip - agouti signaling protein (Norway rat)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2024-12-13
Description
This gene is involved in hair pigmentation. In several strains (ACI, IS, LEA, LEC, NER, and WKAH) this gene encodes a functional protein while in others (BN, BUF, DON, F344, SD, SHR, TM, WKY, and WTC) it lacks a 19 nt indel and is non-protein coding. [provided by RefSeq, Apr 2015]
Predicted to enable neuropeptide hormone activity; type 3 melanocortin receptor binding activity; and type 4 melanocortin receptor binding activity. Predicted to be involved in melanin biosynthetic process and melanosome organization. Predicted to act upstream of or within several processes, including adult feeding behavior; epigenetic programming in the zygotic pronuclei; and melanosome transport. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in pigmentation disease and type 2 diabetes mellitus. Orthologous to human ASIP (agouti signaling protein).

1 Names and Identifiers

1.1 Synonyms

  • ASP
  • agouti-signaling protein
  • Agouti (coat color)
  • agouti switch protein

1.2 Other Identifiers

1.2.1 Alliance Gene ID

1.2.2 RGD ID

1.2.3 Wikidata

3 Proteins

3.1 Protein Function

Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).

3.2 Protein 3D Structures

3.2.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

3.3 Protein Targets

4 Interactions and Pathways

4.1 Interactions

4.2 Pathways

5 Expression

6 Literature

6.1 Gene-Chemical Co-Occurrences in Literature

6.2 Gene-Gene Co-Occurrences in Literature

6.3 Gene-Disease Co-Occurrences in Literature

7 Patents

7.1 Gene-Chemical Co-Occurrences in Patents

7.2 Gene-Gene Co-Occurrences in Patents

7.3 Gene-Disease Co-Occurrences in Patents

8 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  4. NCBI Gene Expression Omnibus (GEO)
  5. Rat Genome Database (RGD)
    LICENSE
    Creative Commons Attribution 4.0 International license (CC BY 4.0)
    https://creativecommons.org/licenses/by/4.0/
  6. STRING: functional protein association networks
  7. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  8. Wikidata
  9. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
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