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mab-10 - NAB transcription cofactor mab-10 (Caenorhabditis elegans)

Gene
Symbol
Dates
  • Create:
    2021-07-27
  • Modify:
    2024-12-16
Description
Enables DNA-binding transcription factor binding activity and transcription coregulator activity. Involved in several processes, including exit from mitosis; regulation of development, heterochronic; and regulation of vulval development. Located in nucleus. Is expressed in several structures, including gonad; hypodermis; pharynx; somatic nervous system; and vulval cell. Orthologous to several human genes including NAB1 (NGFI-A binding protein 1).

1 Names and Identifiers

1.1 Other Identifiers

1.1.1 Alliance Gene ID

1.1.2 Bgee Gene ID

1.1.3 Wikidata

1.1.4 WormBase ID

2 Proteins

2.1 Protein Function

Transcriptional cofactor (PMID: 21862562). Heterochronic protein, involved in timing of a subset of differentiation events during the larval-to-adult transition (PMID: 21862562). Promotes hypodermal terminal differentiation, together with transcription factor lin-29, perhaps as part of a transcriptional complex (PMID: 21862562). Involved in regulating molting by repressing the expression of nuclear hormone receptors nhr-23 and nhr-25 in the adult hypoderm, probably acting in concert with lin-29 (PMID: 21862562).

2.2 Protein 3D Structures

2.2.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

2.3 Protein Targets

3 Interactions and Pathways

3.1 Interactions

3.2 Pathways

4 Expression

5 Literature

5.1 Consolidated References

6 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  4. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  5. NCBI Gene Expression Omnibus (GEO)
  6. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  7. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  8. Wikidata
  9. WormBase
  10. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
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