mab-10 - NAB transcription cofactor mab-10 (Caenorhabditis elegans)
Gene
Symbol
Taxonomy
Dates
- Create:2021-07-27
- Modify:2024-12-16
Description
Enables DNA-binding transcription factor binding activity and transcription coregulator activity. Involved in several processes, including exit from mitosis; regulation of development, heterochronic; and regulation of vulval development. Located in nucleus. Is expressed in several structures, including gonad; hypodermis; pharynx; somatic nervous system; and vulval cell. Orthologous to several human genes including NAB1 (NGFI-A binding protein 1).
Transcriptional cofactor (PMID: 21862562). Heterochronic protein, involved in timing of a subset of differentiation events during the larval-to-adult transition (PMID: 21862562). Promotes hypodermal terminal differentiation, together with transcription factor lin-29, perhaps as part of a transcriptional complex (PMID: 21862562). Involved in regulating molting by repressing the expression of nuclear hormone receptors nhr-23 and nhr-25 in the adult hypoderm, probably acting in concert with lin-29 (PMID: 21862562).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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