Tetraethyl Pyrophosphate
- C8H20O7P2
- (C2H5O)2-PO-O-PO-(OC2H5)2
- TEPP
- TETRAETHYL PYROPHOSPHATE
- Tetraethyl diphosphate
- 107-49-3
- Mortopal
- Create:2005-03-26
- Modify:2025-02-01
C8H20O7P2
(C2H5O)2-PO-O-PO-(OC2H5)2
- TEPP
- tetraethyl pyrophosphate
- TEPP
- TETRAETHYL PYROPHOSPHATE
- Tetraethyl diphosphate
- 107-49-3
- Mortopal
- Vapotone
- Bladan
- Tetron
- Ethyl pyrophosphate
- Tetrastigmine
- Nifos
- Kilmite 40
- Hepthexamite
- Lirohex
- Fosvex
- Grisol
- Killax
- Killex
- Nifost
- Nifos T
- Lethalaire G-52
- Hexamite
- Diphosphoric acid, tetraethyl ester
- Tetron-100
- Ethyl pyrophosphate, tetra-
- Bladan (VAN)
- Ethyl pyrophosphate (Et4P2O7)
- Tetraethylpyrophosphate
- Bis-O,O-diethylphosphoric anhydride
- ENT 18,771
- Rcra waste number P111
- diethoxyphosphoryl diethyl phosphate
- Pyrophosphoric acid, tetraethyl ester
- Tetraethyl pyrofosfaat [Belgian]
- Diphosphoric acid tetraethyl ester
- ethylpyrophosphate
- Pyrophosphate de tetraethyle
- NSC 14707
- EA 1285
- O,O,O,O-Tetraethyl-difosfaat
- O,O,O,O-Tetraethyl-difosfaat [Dutch]
- 28QKT80KX2
- O,O,O,O-Tetraetil-pirofosfato
- DTXSID3034957
- O,O,O,O-Tetraetil-pirofosfato [Italian]
- CHEBI:82149
- pyrophosphoric acid tetraethyl ester
- NSC-14707
- Ethyl pyrophosphate [INN]
- Tetraethyl pyrophosphate, liquid
- DTXCID1014957
- O,O,O,O-Tetraaethyl-diphosphat, bis(O,O-diaethylphosphorsaeure-anhydrid) [German]
- TETRAETHYL PYROPHOSPHATE [MI]
- NSC646213
- O,O,O,O-Tetraaethyl-diphosphat, bis(O,O-diaethylphosphorsaeure-anhydrid)
- Tetraethyl pyrofosfaat (belgian)
- Caswell No. 838
- TEPP [BSI:ISO]
- Tetraethyldifosfat
- ETHYL PYROPHOSPHATE(ET4P207)
- ETHYL PYROPHOSPHATE[ET4P207]
- Tetraethyldifosfat [Czech]
- Tetraethylpyrofosfat
- Tetraethylpyrofosfat [Czech]
- Tetraethyl pyrofosfaat [Dutch]
- HSDB 842
- Tetraethyl pyrofosfaat
- O,O,O,O-TETRAETHYL-DIFOSFAAT (DUTCH)
- O,O,O,O-TETRAETIL-PIROFOSFATO (ITALIAN)
- EINECS 203-495-3
- Pyrophosphate de tetraethyle [French]
- RCRA waste no. P111
- EPA Pesticide Chemical Code 079601
- BRN 1714017
- UNII-28QKT80KX2
- Tetraethylpyrophosphorsaeureester [German]
- Tetraaethylpyrophosphorsaeureester [German]
- AI3-10622
- Tetraethylpyrophosphorsaeureester
- Tetraaethylpyrophosphorsaeureester
- O,O,O,O-TETRAAETHYL-DIPHOSPHAT, BIS(O,O-DIAETHYLPHOSPHORSAEURE-ANHYDRID) (GERMAN)
- HESAMITE
- NITOS
- PYRODUST
- VAPTONE
- TEP (PHOSPHATE)
- O,O-TEPP
- TEPP [ISO]
- TETRON (PESTICIDE)
- O,O,O-Tetraethyl-difosfaat
- TETRON 100
- O,O,O-Tetraetil-pirofosfato
- 4-01-00-01342 (Beilstein Handbook Reference)
- SCHEMBL150611
- Tetraethyl pyrofosfaat(belgian)
- Tetraethyl pyrophosphate, solid
- CHEMBL293787
- T.E.P.
- T.E.P.P.
- Tetraethyl pyrophosphate (OSHA)
- NSC14707
- Tetraphosphoric acid tetraethyl ester
- Tox21_301172
- Bis[O,O-diethylphosphoric anhydride]
- TEPP 1000 microg/mL in n-Hexane
- NSC-646213
- USEPA/OPP Pesticide Code: 079601
- NCGC00164278-01
- NCGC00164278-02
- NCGC00255070-01
- CAS-107-49-3
- TEPP, PESTANAL(R), analytical standard
- DB-040763
- NS00003458
- Tetraethyl pyrophosphate, analytical standard
- WLN: 2OPO&O2&OPO&O2&O2 -DRY MIX
- C19017
- phosphoric acid diethoxyphosphoryl diethyl ester
- WLN: 2OPO&O2&OPO&O2&O2 -LIQUID MIX
- WLN: 2OPO & O2 & OPO & O2 & O2
- Q933664
- Tetraethyl pyrophosphate, liquid [NA3018] [Poison]
- Tetraethyl pyrophosphate, solid [NA2783] [Poison]
- O,O,O-Tetraaethyl-diphosphat, bis(O,O-diaethylphosphorsaeure-anhydrid
263 99.99
161 94
235 93
99 93
155 81
263 999
161 940
99 930
235 930
155 810
H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]
H310 (100%): Fatal in contact with skin [Danger Acute toxicity, dermal]
H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
P262, P264, P270, P273, P280, P301+P316, P302+P352, P316, P321, P330, P361+P364, P391, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 41 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Acute Tox. 2 (100%)
Acute Tox. 1 (100%)
Aquatic Acute 1 (100%)
Acute Tox. 3 (100%)
Eye Irrit. 2 (100%)
Warning: Effects may be delayed up to 12 hours. Caution is advised.
Note: TEPP is a cholinesterase inhibitor.
Signs and Symptoms of TEPP Exposure: Acute exposure to TEPP may produce the following signs and symptoms: sweating, pinpoint pupils, blurred vision, headache, dizziness, profound weakness, muscle spasms, seizures, and coma. Mental confusion and psychosis may occur. Excessive salivation, nausea, vomiting, anorexia, diarrhea, and abdominal pain may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Chest pain may be noted. Hypotension (low blood pressure) may be observed, although hypertension (high blood pressure) is not uncommon. Respiratory symptoms include dyspnea (shortness of breath), pulmonary edema, respiratory depression, and respiratory paralysis.
Emergency Life-Support Procedures: Acute exposure to TEPP may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to TEPP.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. RUSH to a health care facility!
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to TEPP.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas three times with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
7. RUSH to a health care facility!
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer 100% humidified oxygen or other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of TEPP is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step
4. Ipecac should not be administered to children under 6 months of age.Warning: Ingestion of TEPP may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step
4.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. RUSH to a health care facility! (EPA, 1998)
(See general first aid procedures)
Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.
Skin: Water flush immediately - If this chemical contacts the skin, immediately flush the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water. Get medical attention promptly.
Breathing: Respiratory support
Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.
Wear self-contained breathing apparatus and full protective clothing.
Move container from fire area if you can do it without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material. Extinguish with dry chemical, carbon dioxide, water spray, fog, or foam. (EPA, 1998)
Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:
ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024)
5 mg/m3
See: 107493
Excerpt from NIOSH Pocket Guide for TEPP:
Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.
Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.
Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.
Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced.
Change: No recommendation is made specifying the need for the worker to change clothing after the workshift.
Provide:
• EYEWASH - Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substances; this is irrespective of the recommendation involving the wearing of eye protection.
• QUICK DRENCH - Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2024)
(See personal protection and sanitation codes)
Skin: Prevent skin contact - Wear appropriate personal protective clothing to prevent skin contact.
Eyes: Prevent eye contact - Wear appropriate eye protection to prevent eye contact.
Wash skin: When contaminated
Remove: When wet or contaminated
Change: No recommendation
Provide: Eyewash, Quick drench
NIOSH/OSHA
Up to 0.5 mg/m3 :
(APF = 10) Any supplied-air respirator
Up to 1.25 mg/m3 :
(APF = 25) Any supplied-air respirator operated in a continuous-flow mode
Up to 2.5 mg/m3 :
(APF = 50) Any supplied-air respirator that has a tight-fitting facepiece and is operated in a continuous-flow mode
(APF = 50) Any self-contained breathing apparatus with a full facepiece
(APF = 50) Any supplied-air respirator with a full facepiece
Up to 5 mg/m3 :
(APF = 1000) Any supplied-air respirator operated in a pressure-demand or other positive-pressure mode
Emergency or planned entry into unknown concentrations or IDLH conditions:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape:
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister having an N100, R100, or P100 filter.
Click here for information on selection of N, R, or P filters.
Any appropriate escape-type, self-contained breathing apparatus
Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters
Anhydrides
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=IDCBOTIENDVCBQ-UHFFFAOYSA-N
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