Vorinostat
- Vorinostat
- 149647-78-9
- SAHA
- suberoylanilide hydroxamic acid
- N-hydroxy-N'-phenyloctanediamide
- Create:2005-03-25
- Modify:2025-01-04
- 18F Suberoylanilide Hydroxamic Acid
- 18F-SAHA
- 18F-suberoylanilide hydroxamic acid
- M344
- MK 0683
- MK-0683
- MK0683
- N Hydroxy N' phenyloctanediamide
- N-hydroxy-N'-phenyloctanediamide
- N1 Hydroxy N8 phenyloctanediamide
- N1-hydroxy-N8-phenyloctanediamide
- NHNPODA
- suberanilohydroxamic acid
- suberoyl anilide hydroxamic acid
- suberoylanilide hydroxamic acid
- Vorinostat
- zolinza
- Vorinostat
- 149647-78-9
- SAHA
- suberoylanilide hydroxamic acid
- N-hydroxy-N'-phenyloctanediamide
- Zolinza
- N1-hydroxy-N8-phenyloctanediamide
- Suberanilohydroxamic acid
- MK-0683
- MK0683
- SAHA cpd
- Vorinostat [USAN]
- Octanediamide, N-hydroxy-N'-phenyl-
- Vorinostat (SAHA, MK0683)
- N'-hydroxy-N-phenyloctanediamide
- OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE
- CCRIS 8456
- Zolinza (TN)
- vorinostatum
- NSC-701852
- N-Hyrdroxy-N'-phenyloctanediamide
- Vorinostat [USAN:INN]
- MFCD00945317
- NSC-748799
- NSC-759852
- Vorinostat (SAHA)
- 58IFB293JI
- DTXSID6041133
- SHH
- CHEBI:45716
- HSDB 7930
- C14H20N2O3
- VORINOSTAT [MI]
- CHEMBL98
- VORINOSTAT [INN]
- VORINOSTAT [JAN]
- NSC701852
- VORINOSTAT [VANDF]
- VORINOSTAT [MART.]
- VORINOSTAT [WHO-DD]
- DTXCID4021133
- VORINOSTAT [ORANGE BOOK]
- WIN64652
- NSC 701852
- NSC 748799
- NSC 759852
- NCGC00168085-01
- NCGC00168085-02
- Zolinza (TN) (Merck)
- VORINOSTAT (MART.)
- N-hydroxy-N'-phenyl-octane-1,8-diotic acid diamide
- NHNPODA
- Vorinostat MSD
- SMR000486344
- CAS-149647-78-9
- SR-05000000373
- Vorinostat (JAN/USAN)
- MK 0683
- UNII-58IFB293JI
- SKI390
- suberoyl anilide hydroxamic acid
- N Hydroxy N' phenyloctanediamide
- 4lxz
- N1 Hydroxy N8 phenyloctanediamide
- Vorinostat(SAHA)
- Zolinza; SAHA
- 18F-suberoylanilide hydroxamic acid
- Vorinostat (GMP)
- 18F Suberoylanilide Hydroxamic Acid
- SAHA, Suberoylanilide hydroxamic acid
- Vorinostat (SAHA)?
- Vorinostat (Standard)
- 1zz1
- SW-064652
- 8-(hydroxyamino)-8-oxo-N-phenyl-octanamide
- cid_5311
- SCHEMBL9018
- Suberoylanilidehydroxamic Acid
- MLS001065855
- MLS006011941
- GTPL6852
- BDBM19149
- Vorinostat (SAHA; MK0683)
- L01XX38
- MSK-390
- n-hydroxy-n'-phenyl-octanediamide
- SUBERANILOHYDROXAMINIC ACID
- 1t69
- N-hydroxy-N''-phenyloctanediamide
- BCPP000018
- HMS2219L20
- HMS3264D20
- HMS3327C12
- HMS3426G03
- HMS3650D09
- HMS3654G11
- HMS3715E22
- HMS3745M03
- Pharmakon1600-01502267
- BCP01858
- EX-A2745
- SAHA, >=98% (HPLC)
- Vorinostat,SAHA,Zolinza,MK-0683
- Tox21_112605
- Tox21_113623
- Vorinostat,CAS:149647-78-9
- HB1396
- HY-10221G
- HY-10221R
- NSC748799
- NSC759852
- Octanediamide, N1-hydroxy-N8-phenyl
- s1047
- SK1390
- AKOS015966648
- Tox21_112605_1
- AC-1923
- CCG-208659
- CS-0589
- DB02546
- DG-0025
- SB17319
- NCGC00168085-03
- NCGC00168085-04
- NCGC00168085-05
- NCGC00168085-13
- BP-25652
- BP-30216
- BV164560
- HY-10221
- SY009383
- H1388
- NS00068618
- SW199536-4
- D06320
- EN300-120641
- AB00375377-07
- AB00375377-08
- AB00375377-09
- AB01644613_25
- Q905901
- Vorinostat, SAHA, suberoylanilide hydroxamic acid
- SR-05000000373-2
- SR-05000000373-6
- SR-05000000373-8
- W-201327
- BRD-K81418486-001-01-2
- BRD-K81418486-001-10-3
- BRD-K81418486-001-12-9
- BRD-K81418486-001-13-7
- BRD-K81418486-001-17-8
- BRD-K81418486-001-18-6
- BRD-K81418486-001-44-2
- BRD-K81418486-001-47-5
- L-001079038
- Z1530532755
- N-Hydroxy-N inverted exclamation mark -phenyloctanediamide
- MK0683 , suberoylanilide hydroxamic acid , SAHA
- 1227736-21-1
300.231689 23744
298.215057 6352
301.234253 3576
184.076721 3456
159.067245 3452
232.133286 100
94.065704 70.57
139.075439 52.31
83.086205 33
111.080872 26.39
265.1546 999
232.133 586
172.0966 349
94.0651 57
232.133 999
172.0966 464
94.0651 211
139.0753 204
83.0855 83
Vorinostat is approved to treat:
• Cutaneous T-cell lymphoma that has not gotten better, has gotten worse, or has recurred (come back) during or after two systemic therapies.
Vorinostat is also being studied in the treatment of other types of cancer.
- Cytoplasm
- Extracellular
- Membrane
H302 (58.9%): Harmful if swallowed [Warning Acute toxicity, oral]
H341 (99.1%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]
H360 (72.9%): May damage fertility or the unborn child [Danger Reproductive toxicity]
H360FD (26.2%): May damage fertility; May damage the unborn child [Danger Reproductive toxicity]
H372 (59.8%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
H400 (60.7%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
H410 (58.9%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]
P203, P260, P264, P270, P273, P280, P301+P317, P318, P319, P330, P391, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 107 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Acute Tox. 4 (58.9%)
Muta. 2 (99.1%)
Repr. 1A (72.9%)
Repr. 1B (26.2%)
STOT RE 1 (59.8%)
Aquatic Acute 1 (60.7%)
Aquatic Chronic 1 (58.9%)
In clinical trials of vorinostat in patients with CTCL, the rates of serum enzyme elevations during therapy were rarely mentioned and only occasional episodes of mild elevations were recorded. Minor elevations in serum ALT levels occurred in 15% to 45% of patients, but values above 5 times ULN were rare and there were no reports of hepatitis, jaundice or clinically apparent liver injury among the treated subjects. Vorinostat has had limited clinical use, but there have been no published reports of its association with significant liver injury.
Likelihood score: E (unlikely cause of clinically apparent liver injury).
M Chen, V Vijay, Q Shi, Z Liu, H Fang, W Tong. FDA-Approved Drug Labeling for the Study of Drug-Induced Liver Injury, Drug Discovery Today, 16(15-16):697-703, 2011. PMID:21624500 DOI:10.1016/j.drudis.2011.05.007
M Chen, A Suzuki, S Thakkar, K Yu, C Hu, W Tong. DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug Discov Today 2016, 21(4): 648-653. PMID:26948801 DOI:10.1016/j.drudis.2016.02.015
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=WAEXFXRVDQXREF-UHFFFAOYSA-N
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