Uranium tetrachloride
PubChem CID
66210
Structure
Molecular Formula
Synonyms
- Uranium chloride (UCl4)
- tetrachlorouranium
- Uranium(IV) chloride
- 10026-10-5
- EINECS 233-057-7
Molecular Weight
379.8 g/mol
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Dates
- Create:2005-03-27
- Modify:2024-12-28
Description
Uranium tetrachloride is a chloride of uranium It is used as feed in the electromagnetic isotope separation (EMIS) process of uranium enrichment. Uranium is a chemical element that has the symbol U and atomic number 92. It is a normal part of rocks, soil, air, and water, and occurs in nature in the form of minerals. (L248, L249, L254)
L248: Wikipedia. Uranium. Last Updated 28 May 2009. http://en.wikipedia.org/wiki/Uranium
L249: ATSDR - Agency for Toxic Substances and Disease Registry (1999). Toxicological profile for uranium. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=440&tid=77
L254: Wikipedia. Uranium tetrachloride. Last Updated 23 May 2009. http://en.wikipedia.org/wiki/Uranium_tetrachloride
Chemical Structure Depiction
Conformer generation is disallowed since MMFF94s unsupported element
tetrachlorouranium
Computed by Lexichem TK 2.7.0 (PubChem release 2021.10.14)
InChI=1S/4ClH.U/h4*1H;/q;;;;+4/p-4
Computed by InChI 1.0.6 (PubChem release 2021.10.14)
HPICRATUQFHULE-UHFFFAOYSA-J
Computed by InChI 1.0.6 (PubChem release 2021.10.14)
Cl[U](Cl)(Cl)Cl
Computed by OEChem 2.3.0 (PubChem release 2021.10.14)
Cl4U
Computed by PubChem 2.2 (PubChem release 2021.10.14)
54327-77-4
Property Name
Property Value
Reference
Property Name
Molecular Weight
Property Value
379.8 g/mol
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Hydrogen Bond Donor Count
Property Value
0
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Hydrogen Bond Acceptor Count
Property Value
0
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Rotatable Bond Count
Property Value
0
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Exact Mass
Property Value
379.92325 Da
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Monoisotopic Mass
Property Value
377.92620 Da
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Topological Polar Surface Area
Property Value
0Ų
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Heavy Atom Count
Property Value
5
Reference
Computed by PubChem
Property Name
Formal Charge
Property Value
0
Reference
Computed by PubChem
Property Name
Complexity
Property Value
19.1
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Isotope Atom Count
Property Value
0
Reference
Computed by PubChem
Property Name
Defined Atom Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Undefined Atom Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Defined Bond Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Undefined Bond Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Covalently-Bonded Unit Count
Property Value
1
Reference
Computed by PubChem
Property Name
Compound Is Canonicalized
Property Value
Yes
Reference
Computed by PubChem (release 2021.10.14)
Dark green crystals; [Merck Index] Green salt; [ATSDR ToxProfiles]
Physical/Radiation -> Radioactive Compounds
Follow these links to do a live 2D search or do a live 3D search for this compound, sorted by annotation score. This section is deprecated (see here for details), but these live search links provide equivalent functionality to the table that was previously shown here.
Mixtures, Components, and Neutralized Forms Count
Similar Compounds (2D)
Similar Conformers (3D)
Uranium is absorbed in low amounts via oral, inhalation, and dermal routes. Uranium in body fluids generally exists as the uranyl ion (UO2)2+ complexed with anions, such as citrate and bicarbonate, or plasma proteins. Uranium preferentially distributes to bone, liver, and kidney. The large majority of uranium that enters the body is not absorbed and is eliminated from the body via the urine and faeces. (L248)
L248: Wikipedia. Uranium. Last Updated 28 May 2009. http://en.wikipedia.org/wiki/Uranium
Uranium tetrachloride is used as feed in the electromagnetic isotope separation (EMIS) process of uranium enrichment. (L254)
L254: Wikipedia. Uranium tetrachloride. Last Updated 23 May 2009. http://en.wikipedia.org/wiki/Uranium_tetrachloride
EPA TSCA Commercial Activity Status
Uranium chloride (UCl4): INACTIVE
See Uranium and linked occupational diseases.
Exposure Summary
Biological Exposure Indices (BEI) [ACGIH] - Uranium in urine = 200 ug/L at end of shift; [ACGIH]
ACGIH - Documentation of the TLVs and BEIs, 7th Ed. Cincinnati: ACGIH Worldwide, 2020.
ACGIH - Documentation of the TLVs and BEIs, 7th Ed. Cincinnati: ACGIH Worldwide, 2020.
0.05 [mg/m3], as U (sol), 0.25 mg/m3, as U (insol)
10.0 [mg/m3], as U
0.2 [mg/m3], as U
TLV-STEL
0.6 [mg/m3], as U
Uranium is combined with either bicarbonate or a plasma protein in the blood but once in the kidney, it is released and forms complexes with phosphate ligands and proteins in the tubular wall, causing damage. Uranium may also inhibit both sodium transport-dependent and independent ATP utilization and mitochondrial oxidative phosphorylation in the renal proximal tubule. Uranium causes respiratory diseases by damaging alveolar epithelium type II cells in the lungs. Uranium induces c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) activation, which in turn induces tumor necrosis factor alpha (TNF-alpha) secretion and generates and inflammatory response in the lungs. Studies have shown that the more soluble the uranium salt, the more toxic it is. Ionizing radiation produced by uranium damages the DNA, resulting in gene mutations and chromosomal aberrations. This can both both initiate and promote carcinogenesis, and interfere with reproduction and development. (L249, A160)
A160: Gazin V, Kerdine S, Grillon G, Pallardy M, Raoul H: Uranium induces TNF alpha secretion and MAPK activation in a rat alveolar macrophage cell line. Toxicol Appl Pharmacol. 2004 Jan 1;194(1):49-59. PMID:14728979
L249: ATSDR - Agency for Toxic Substances and Disease Registry (1999). Toxicological profile for uranium. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=440&tid=77
Carcinogen Classification
Uranium: Group 1, carcinogenic to humans (L135)
L248: Wikipedia. Uranium. Last Updated 28 May 2009. http://en.wikipedia.org/wiki/Uranium
L249: ATSDR - Agency for Toxic Substances and Disease Registry (1999). Toxicological profile for uranium. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=440&tid=77
Oral (L249) ; inhalation (L249) ; dermal (L249)
L249: ATSDR - Agency for Toxic Substances and Disease Registry (1999). Toxicological profile for uranium. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=440&tid=77
Ingestion of uranium may cause vomiting and diarrhea. (L248)
L248: Wikipedia. Uranium. Last Updated 28 May 2009. http://en.wikipedia.org/wiki/Uranium
L134: ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/mrls/
EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=HPICRATUQFHULE-UHFFFAOYSA-J
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/Uranium tetrachloridehttps://commonchemistry.cas.org/detail?cas_rn=10026-10-5
- ChemIDplusUranium tetrachloridehttps://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0010026105ChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- EPA Chemicals under the TSCAUranium chloride (UCl4)https://www.epa.gov/chemicals-under-tscaEPA TSCA Classificationhttps://www.epa.gov/tsca-inventory
- EPA DSSToxUranium chloride (UCl4)https://comptox.epa.gov/dashboard/DTXSID1064906CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
- European Chemicals Agency (ECHA)LICENSEUse of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.https://echa.europa.eu/web/guest/legal-noticeUranium tetrachloridehttps://echa.europa.eu/substance-information/-/substanceinfo/100.030.040
- Haz-Map, Information on Hazardous Chemicals and Occupational DiseasesLICENSECopyright (c) 2022 Haz-Map(R). All rights reserved. Unless otherwise indicated, all materials from Haz-Map are copyrighted by Haz-Map(R). No part of these materials, either text or image may be used for any purpose other than for personal use. Therefore, reproduction, modification, storage in a retrieval system or retransmission, in any form or by any means, electronic, mechanical or otherwise, for reasons other than personal use, is strictly prohibited without prior written permission.https://haz-map.com/AboutUranium tetrachloridehttps://haz-map.com/Agents/1748
- Springer Nature
- Thieme ChemistryLICENSEThe Thieme Chemistry contribution within PubChem is provided under a CC-BY-NC-ND 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc-nd/4.0/
- Toxin and Toxin Target Database (T3DB)LICENSET3DB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (T3DB) and the original publication.http://www.t3db.ca/downloadsUranium tetrachloridehttp://www.t3db.ca/toxins/T3D1167
- Wikidatauranium tetrachloridehttps://www.wikidata.org/wiki/Q413036
- Wikipediauranium tetrachloridehttps://en.wikipedia.org/wiki/Uranium_tetrachlorideUranium(IV) chloridehttps://en.wikipedia.org/wiki/Uranium(IV)_chloride
- Wiley
- PubChem
- EPA Substance Registry ServicesEPA SRS List Classificationhttps://sor.epa.gov/sor_internet/registry/substreg/LandingPage.do
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 388308255https://pubchem.ncbi.nlm.nih.gov/substance/388308255
CONTENTS