1H-Purine-2,6-dione, 3,9-dihydro-1,3-dimethyl-, hydrate (1:1)
- C7H8N4O2.H2O
- C7H10N4O3
- Theophylline monohydrate
- 5967-84-0
- 1,3-Dimethylxanthine monohydrate
- Theolair-SR
- Theophylline (monohydrate)
- Create:2005-08-01
- Modify:2025-01-18
- 1,3 Dimethylxanthine
- 1,3-Dimethylxanthine
- 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione
- Accurbron
- Aerobin
- Aerolate
- Afonilum Retard
- Anhydrous, Theophylline
- Aquaphyllin
- Armophylline
- Bronchoparat
- Bronkodyl
- Constant T
- Constant-T
- ConstantT
- ct, theo von
- Elixophyllin
- Euphylong
- Glycinate, Theophylline Sodium
- Glycine Theophyllinate
- Lodrane
- Monospan
- Nuelin
- Nuelin S.A.
- Quibron T SR
- Quibron T-SR
- Quibron TSR
- Slo Phyllin
- Slo-Phyllin
- SloPhyllin
- Sodium Glycinate, Theophylline
- Somophyllin T
- Somophyllin-T
- SomophyllinT
- Sustaire
- Synophylate
- Theo 24
- Theo Dur
- theo von ct
- Theo-24
- Theo-Dur
- Theo24
- Theobid
- Theocin
- Theoconfin Continuous
- Theodur
- Theolair
- Theolix
- Theon
- Theonite
- Theopek
- Theophyllinate, Glycine
- Theophylline
- Theophylline Anhydrous
- Theophylline Sodium Glycinate
- Theospan
- Theostat
- Theovent
- Uniphyl
- Uniphyllin
- Uniphylline
- von ct, theo
- Theophylline monohydrate
- 5967-84-0
- 1,3-Dimethylxanthine monohydrate
- Theolair-SR
- Theophylline (monohydrate)
- Dimethylxanthine
- Theo-24
- AEROLATE JR
- Theophylline hydrate
- THEOCLEAR-100
- 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, monohydrate
- THEOCLEAR L.A.-260
- C137DTR5RG
- 5967-84-0 (hydrate)
- UNII-C137DTR5RG
- 1,3-dimethyl-7H-purine-2,6-dione;hydrate
- Quibron Plus
- Theophylline (USP)
- Theophylline [USP]
- Theo-Sav
- THEOPHYLLINE IN DEXTROSE 5% IN PLASTIC CONTAINER
- THEOPHYLLINE AND DEXTROSE 5% IN PLASTIC CONTAINER
- THEOPHYLLINE 0.2% AND DEXTROSE 5% IN PLASTIC CONTAINER
- THEOPHYLLINE 0.4% AND DEXTROSE 5% IN PLASTIC CONTAINER
- THEOPHYLLINE 0.04% AND DEXTROSE 5% IN PLASTIC CONTAINER
- THEOPHYLLINE 0.08% AND DEXTROSE 5% IN PLASTIC CONTAINER
- THEOPHYLLINE 0.16% AND DEXTROSE 5% IN PLASTIC CONTAINER
- THEOPHYLLINE 0.32% AND DEXTROSE 5% IN PLASTIC CONTAINER
- 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione hydrate
- THEOPHYLLINE [II]
- THEOPHYLLINE [IARC]
- THEOPHYLLINE [EP IMPURITY]
- THEOPHYLLINE [USP MONOGRAPH]
- NSC 757346
- CAFFEINE IMPURITY A [EP IMPURITY]
- DICURIN PROCAINE COMPONENT THEOPHYLLINE
- DIPROPHYLLINE IMPURITY B [EP IMPURITY]
- THEOPHYLLINE MONOHYDRATE [EP MONOGRAPH]
- austyn hydrate
- Theophylline [USP:BAN:JAN]
- MERSALYL-THEOPHYLLINE COMPONENT THEOPHYLLINE
- CAFFEINE MONOHYDRATE IMPURITY A [EP IMPURITY]
- Accurbron (TN)
- Prestwick_1055
- THEOPHYLLINE [JAN]
- THEOPHYLLINE [VANDF]
- SCHEMBL387338
- CHEMBL1355736
- HY-B0809A
- DTXSID40208361
- INQSMEFCAIHTJG-UHFFFAOYSA-N
- HMS1570P07
- HMS2097P07
- HMS3714P07
- THEOPHYLLINE [ORANGE BOOK]
- MFCD00151659
- AKOS015960702
- CCG-220873
- NCGC00017052-01
- THEOPHYLLINE MONOHYDRATE [WHO-DD]
- AC-12160
- AC-33575
- DA-58518
- TS-07743
- CAS-5967-84-0
- CS-0013828
- D06103
- 1,3-Dimethyl-1H-purine-2,6(3H,7H)-dionehydrate
- SR-01000075195-6
- 1,3-Dimethyl-1H-purine-2,6(3H,7H)-dione hydrate
- Q47495785
- 1H-Purine-2,6-dione, 3,9-dihydro-1,3-dimethyl-, hydrate (1:1)
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
H311 (20%): Toxic in contact with skin [Danger Acute toxicity, dermal]
H330 (20%): Fatal if inhaled [Danger Acute toxicity, inhalation]
P260, P262, P264, P270, P271, P280, P284, P301+P316, P302+P352, P304+P340, P316, P320, P321, P330, P361+P364, P403+P233, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 5 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Acute Tox. 3 (100%)
Acute Tox. 3 (20%)
Acute Tox. 2 (20%)
◉ Summary of Use during Lactation
Expert opinion considers use of theophylline to be acceptable during breastfeeding. Maternal theophylline use may occasionally cause stimulation and irritability and fretful sleep in infants. Newborn and especially preterm infants are most likely to be affected because of their slow elimination and low serum protein binding of theophylline. There is no need to avoid theophylline products; however, keep maternal serum concentrations in the lower part of the therapeutic range and monitor the infant for signs of theophylline side effects. Infant serum theophylline concentrations can help to determine if signs of agitation are due to theophylline. Avoiding breastfeeding for 2 hours after intravenous or 4 hours after an immediate-release oral theophylline product can decrease the dose received by the breastfed infant. When theophylline is given as an oral sustained-release product, timing of nursing with respect to the dose is of little or no benefit.
◉ Effects in Breastfed Infants
Irritability and fretful sleeping occurred in a 3-day-old breastfed infant on days of maternal aminophylline intake of 200 mg every 6 hours. These effects ceased with discontinuation and recurred on rechallenge over the next 9 months. These effects were probably caused by theophylline in breastmilk. Another five infants reported in this paper showed no adverse reactions after maternal theophylline ingestion. Accumulation of theophylline in infant serum appears most likely in neonates and premature infants because they eliminate theophylline slowly.
◉ Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=INQSMEFCAIHTJG-UHFFFAOYSA-N
- Australian Industrial Chemicals Introduction Scheme (AICIS)1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, monohydratehttps://services.industrialchemicals.gov.au/search-assessments/1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, monohydratehttps://services.industrialchemicals.gov.au/search-inventory/
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/1H-Purine-2,6-dione, 3,9-dihydro-1,3-dimethyl-, hydrate (1:1)https://commonchemistry.cas.org/detail?cas_rn=5967-84-0
- ChemIDplusTheophylline [USP:BAN:JAN]https://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0005967840ChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- EPA DSSToxTheophylline monohydratehttps://comptox.epa.gov/dashboard/DTXSID40208361CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
- European Chemicals Agency (ECHA)LICENSEUse of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.https://echa.europa.eu/web/guest/legal-notice1H-Purine-2,6-dione, 3,9-dihydro-1,3-dimethyl-, hydrate (1:1)https://echa.europa.eu/substance-information/-/substanceinfo/100.110.6291H-Purine-2,6-dione, 3,9-dihydro-1,3-dimethyl-, hydrate (1:1) (EC: 611-861-2)https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/21441
- FDA Global Substance Registration System (GSRS)LICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linking
- ChEMBLLICENSEAccess to the web interface of ChEMBL is made under the EBI's Terms of Use (http://www.ebi.ac.uk/Information/termsofuse.html). The ChEMBL data is made available on a Creative Commons Attribution-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-sa/3.0/).http://www.ebi.ac.uk/Information/termsofuse.html
- Drug Gene Interaction database (DGIdb)LICENSEThe data used in DGIdb is all open access and where possible made available as raw data dumps in the downloads section.http://www.dgidb.org/downloadsTHEOPHYLLINEhttps://www.dgidb.org/drugs/rxcui:10438
- Drugs and Lactation Database (LactMed)
- EU Clinical Trials Register
- KEGGLICENSEAcademic users may freely use the KEGG website. Non-academic use of KEGG generally requires a commercial licensehttps://www.kegg.jp/kegg/legal.htmlAnatomical Therapeutic Chemical (ATC) classificationhttp://www.genome.jp/kegg-bin/get_htext?br08303.kegTarget-based classification of drugshttp://www.genome.jp/kegg-bin/get_htext?br08310.kegRisk category of Japanese OTC drugshttp://www.genome.jp/kegg-bin/get_htext?br08312.keg
- Springer Nature
- Wikidatatheophylline monohydratehttps://www.wikidata.org/wiki/Q47495785
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.htmlTheophyllinehttps://www.ncbi.nlm.nih.gov/mesh/68013806Bronchodilator Agentshttps://www.ncbi.nlm.nih.gov/mesh/68001993Phosphodiesterase Inhibitorshttps://www.ncbi.nlm.nih.gov/mesh/68010726Vasodilator Agentshttps://www.ncbi.nlm.nih.gov/mesh/68014665Purinergic P1 Receptor Antagonistshttps://www.ncbi.nlm.nih.gov/mesh/68058915
- PubChem
- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
- NORMAN Suspect List ExchangeLICENSEData: CC-BY 4.0; Code (hosted by ECI, LCSB): Artistic-2.0https://creativecommons.org/licenses/by/4.0/NORMAN Suspect List Exchange Classificationhttps://www.norman-network.com/nds/SLE/
- NCI Thesaurus (NCIt)LICENSEUnless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.https://www.cancer.gov/policies/copyright-reuseNCI Thesaurushttps://ncit.nci.nih.gov
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 388328219https://pubchem.ncbi.nlm.nih.gov/substance/388328219