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Talc

PubChem CID
26924
Structure
Talc_small.png
Molecular Formula
Synonyms
  • Mussolinite
  • Agalite
  • Asbestine
  • Snowgoose
  • Soapstone
Molecular Weight
379.27 g/mol
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Dates
  • Create:
    2005-08-08
  • Modify:
    2025-01-18
Description
Talc containing asbestiform fibers can cause cancer according to The World Health Organization's International Agency for Research on Cancer (IARC).

1 Structures

1.1 2D Structure

Chemical Structure Depiction
Talc.png

1.2 3D Status

Conformer generation is disallowed since MMFF94s unsupported element, mixture or salt

2 Names and Identifiers

2.1 Computed Descriptors

2.1.1 IUPAC Name

trimagnesium;dioxido(oxo)silane;hydroxy-oxido-oxosilane
Computed by Lexichem TK 2.7.0 (PubChem release 2021.10.14)

2.1.2 InChI

InChI=1S/3Mg.2HO3Si.2O3Si/c;;;4*1-4(2)3/h;;;2*1H;;/q3*+2;2*-1;2*-2
Computed by InChI 1.0.6 (PubChem release 2021.10.14)

2.1.3 InChIKey

KNXVOGGZOFOROK-UHFFFAOYSA-N
Computed by InChI 1.0.6 (PubChem release 2021.10.14)

2.1.4 SMILES

O[Si](=O)[O-].O[Si](=O)[O-].[O-][Si](=O)[O-].[O-][Si](=O)[O-].[Mg+2].[Mg+2].[Mg+2]
Computed by OEChem 2.3.0 (PubChem release 2024.12.12)

2.2 Molecular Formula

H2Mg3O12Si4
Computed by PubChem 2.2 (PubChem release 2021.10.14)

2.3 Other Identifiers

2.3.1 CAS

14807-96-6

2.3.2 Deprecated CAS

110540-41-5, 11119-41-8, 1170673-66-1, 12420-12-1, 1308319-75-6, 1385633-70-4, 184973-42-0, 2403462-24-6, 2640599-87-5, 37232-12-5, 8043-56-9, 99638-63-8

2.3.3 RTECS Number

2.4 Synonyms

2.4.1 Depositor-Supplied Synonyms

3 Chemical and Physical Properties

3.1 Computed Properties

Property Name
Molecular Weight
Property Value
379.27 g/mol
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Hydrogen Bond Donor Count
Property Value
2
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Hydrogen Bond Acceptor Count
Property Value
12
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Rotatable Bond Count
Property Value
0
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Exact Mass
Property Value
377.8174567 Da
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Monoisotopic Mass
Property Value
377.8174567 Da
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Topological Polar Surface Area
Property Value
247 Ų
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Heavy Atom Count
Property Value
19
Reference
Computed by PubChem
Property Name
Formal Charge
Property Value
0
Reference
Computed by PubChem
Property Name
Complexity
Property Value
43.5
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Isotope Atom Count
Property Value
0
Reference
Computed by PubChem
Property Name
Defined Atom Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Undefined Atom Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Defined Bond Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Undefined Bond Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Covalently-Bonded Unit Count
Property Value
7
Reference
Computed by PubChem
Property Name
Compound Is Canonicalized
Property Value
Yes
Reference
Computed by PubChem (release 2021.10.14)

3.2 Experimental Properties

3.2.1 Physical Description

Odorless, white powder; Containing no asbestos and less than 1% quartz; [NIOSH]
Odorless, white-gray powder; [NIOSH]

3.3 Chemical Classes

Mineral Dusts -> Other Mineral Dusts

4 Spectral Information

4.1 IR Spectra

4.1.1 FTIR Spectra

1 of 2
Instrument Name
PERKIN-ELMER 1710
Technique
NUJOL MULL
Source of Sample
Hercules, Inc., Wilmington, Delaware
Copyright
Copyright © 1980, 1981-2024 John Wiley & Sons, Inc. All Rights Reserved.
Thumbnail
Thumbnail
2 of 2
Instrument Name
DigiLab FTS-40
Technique
FTIR
Copyright
Copyright © 1980, 1981-2024 John Wiley & Sons, Inc. All Rights Reserved.
Thumbnail
Thumbnail

4.2 Raman Spectra

1 of 2
Instrument Name
Bio-Rad FTS 175C with Raman accessory
Technique
FT-Raman
Source of Sample
Fluka Chemie AG, Buchs, Switzerland
Catalog Number
86255
Copyright
Copyright © 1980, 1981-2024 John Wiley & Sons, Inc. All Rights Reserved.
Thumbnail
Thumbnail
2 of 2
Instrument Name
Bio-Rad FTS 175C with Raman accessory
Technique
FT-Raman
Source of Sample
Fluka Chemie AG, Buchs, Switzerland
Catalog Number
86255
Copyright
Copyright © 1980, 1981-2024 John Wiley & Sons, Inc. All Rights Reserved.
Thumbnail
Thumbnail

6 Chemical Vendors

7 Use and Manufacturing

7.1 Uses

Sources/Uses
Used as a paint additive and rubber lubricant; [Levy, p. 422] Crystalline silica not bound to other minerals is free silica. Silicates are minerals in which silicon and oxygen are combined with other elements. [Rom, p. 364]
Levy - Levy BS, Wegman DH, Baron SL, Sokas RK (eds). _Occupational and Environmental Health: Recognizing and Preventing Disease and Injury, _6th Ed. Oxford: Oxford University Press, 2011., p. 422
Rom - Rom WN (ed). _Environmental and Occupational Medicine, _4th Ed. Philadelphia: Lippincott Williams & Wilkins, 2007., p. 364
Industrial Processes with risk of exposure

Painting (Pigments, Binders, and Biocides) [Category: Paint]

Mining [Category: Industry]

Activities with risk of exposure
Lithography printing [Category: Hobbies]
Sources/Uses
Soapstone is used as a paint, rubber, and soap pigment; also used as a lubricant for machinery and a mold release. [ACGIH]
ACGIH - Documentation of the TLVs and BEIs, 7th Ed. Cincinnati: ACGIH Worldwide, 2020.
Industrial Processes with risk of exposure
Mining [Category: Industry]

8 Safety and Hazards

8.1 Hazards Identification

8.1.1 Hazards Summary

Interstitial fibrosis can develop in workers heavily exposed to talc, but it is not yet clear how much is due to talc versus talc contaminants. [Harber, p. 349] We confirmed the lack of association between exposure to asbestos-free talc, lung cancer, and mesothelioma. Increased mortality from pneumoconiosis among miners is attributable to past exposure to silica. [PMID 28691999]
Harber - Harber P, Schenker MB, Balmes JR (eds). Occupational and Environmental Respiratory Diseases. St. Louis: Mosby, 1996., p. 349
Soapstone does not have a precise mineralogical definition. It is at least 50% talc. The TLV for soapstone containing no asbestos and less than 1% silica is based on the fibrogenic potential of talc. [ACGIH] Crystalline silica not bound to other minerals is free silica. Silicates are minerals in which silicon and oxygen are combined with other elements. [Rom, p. 364]
ACGIH - Documentation of the TLVs and BEIs, 7th Ed. Cincinnati: ACGIH Worldwide, 2020.
Rom - Rom WN (ed). _Environmental and Occupational Medicine, _4th Ed. Philadelphia: Lippincott Williams & Wilkins, 2007., p. 364

8.2 Exposure Control and Personal Protection

8.2.1 Immediately Dangerous to Life or Health (IDLH)

1000.0 [mg/m3]

Excerpts from Documentation for IDLHs: Basis for revised IDLH: The available toxicological data contain no evidence that an acute exposure to a high concentration of talc would impede escape or cause any irreversible health effects within 30 minutes. However, the revised IDLH for talc is 1,000 mg/m3 based on being 500 times the NIOSH REL of 2 mg/m3 (500 is an assigned protection factor for respirators and was used arbitrarily during the Standards Completion Program for deciding when the most protective respirators should be used for particulates).

3000.0 [mg/m3]

Excerpts from Documentation for IDLHs: Basis for revised IDLH: The available toxicological data contain no evidence that an acute exposure to a high concentration of soapstone would impede escape or cause any irreversible health effects within 30 minutes. However, the revised IDLH for soapstone is 3,000 mg/m3 based on being 500 times the NIOSH REL of 6 mg/m3 (500 is an assigned protection factor for respirators and was used arbitrarily during the Standards Completion Program for deciding when the most protective respirators should be used for particulates).

8.2.2 Threshold Limit Values (TLV)

2.0 [mg/m3], respirable fraction (particulate matter containing no asbestos and < 1% crystalline silica)

9 Toxicity

9.1 Toxicological Information

9.1.1 NIOSH Toxicity Data

9.1.2 Adverse Effects

Fibrogenic - Inducing tissue injury and fibrosis (scarring).

ACGIH Carcinogen - Not Classifiable.

Fibrogenic - Inducing tissue injury and fibrosis (scarring).

10 Associated Disorders and Diseases

Associated Occupational Diseases with Exposure to the Compound
Pneumoconioses, other [Category: Pneumoconiosis (Pulmonary Fibrosis)]

11 Literature

11.1 Consolidated References

11.2 Chemical Co-Occurrences in Literature

11.3 Chemical-Gene Co-Occurrences in Literature

11.4 Chemical-Disease Co-Occurrences in Literature

12 Patents

12.1 Depositor-Supplied Patent Identifiers

12.2 Chemical Co-Occurrences in Patents

12.3 Chemical-Disease Co-Occurrences in Patents

12.4 Chemical-Gene Co-Occurrences in Patents

13 Biological Test Results

13.1 BioAssay Results

14 Classification

14.1 NCI Thesaurus Tree

14.2 ChemIDplus

14.3 MolGenie Organic Chemistry Ontology

15 Information Sources

  1. California Office of Environmental Health Hazard Assessment (OEHHA)
  2. CAS Common Chemistry
    LICENSE
    The data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.
    https://creativecommons.org/licenses/by-nc/4.0/
  3. ChemIDplus
    ChemIDplus Chemical Information Classification
    https://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
  4. Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
    LICENSE
    Copyright (c) 2022 Haz-Map(R). All rights reserved. Unless otherwise indicated, all materials from Haz-Map are copyrighted by Haz-Map(R). No part of these materials, either text or image may be used for any purpose other than for personal use. Therefore, reproduction, modification, storage in a retrieval system or retransmission, in any form or by any means, electronic, mechanical or otherwise, for reasons other than personal use, is strictly prohibited without prior written permission.
    https://haz-map.com/About
    Talc (containing no asbestos)
    https://haz-map.com/Agents/28
  5. Therapeutic Target Database (TTD)
  6. SpectraBase
  7. The National Institute for Occupational Safety and Health (NIOSH)
    LICENSE
    The information provided using CDC Web site is only intended to be general summary information to the public. It is not intended to take the place of either the written law or regulations.
    https://www.cdc.gov/Other/disclaimer.html
    Talc (powder), containing no asbestos fibers
    https://www.cdc.gov/niosh-rtecs/WW2959F0.html
  8. PubChem
  9. NCI Thesaurus (NCIt)
    LICENSE
    Unless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.
    https://www.cancer.gov/policies/copyright-reuse
  10. MolGenie
    MolGenie Organic Chemistry Ontology
    https://github.com/MolGenie/ontology/
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