Solifenacin Succinate
- Solifenacin succinate
- 242478-38-2
- Vesicare
- Solifenacin (Succinate)
- Solifenacin succinate [USAN]
- Create:2005-08-09
- Modify:2025-01-11
- 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-1-phenyl-,1- azabicyclo(2.2.2)oct-3-yl ester, (R-(R*,S*))-
- 905, YM
- quinuclidin-3'-yl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate monosuccinate
- solifenacin
- solifenacin succinate
- Succinate, Solifenacin
- vesicare
- YM 905
- YM905
- Solifenacin succinate
- 242478-38-2
- Vesicare
- Solifenacin (Succinate)
- Solifenacin succinate [USAN]
- UNII-KKA5DLD701
- 1-Azabicyclo[2.2.2]octan-8-yl (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate butanedioic acid
- KKA5DLD701
- YM67905
- YM905
- YM-67905
- VESICARE LS
- YM 905
- YM-905
- [(3R)-1-azabicyclo[2.2.2]octan-3-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate;butanedioic acid
- Vesikur
- SOLIFENACIN SUCCINATE (MART.)
- SOLIFENACIN SUCCINATE [MART.]
- SOLIFENACIN SUCCINATE (USP-RS)
- SOLIFENACIN SUCCINATE [USP-RS]
- (S)-(R)-Quinuclidin-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate succinate
- CHEMBL1200803
- Quinuclidin-3'-yl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylatemonosuccinate
- SOLIFENACIN SUCCINATE (EP MONOGRAPH)
- SOLIFENACIN SUCCINATE [EP MONOGRAPH]
- Succinate, Solifenacin
- Solifenacin Succinate Salt
- Vesicare OD
- VESIcareLS
- solifenacin succiate
- Vesicare (TN)
- Solifenacin Succinate; (3R)-1-Azabicyclo[2.2.2]octan-3-yl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate hydrogen butanedioate
- Isoprenalinoe Sulfate
- solifenacine succinate
- solifenacin succinate5 mg
- solifenacin succinate10 mg
- Solifenacin Succinate Tablets
- Solifenacin succinate- Bio-X
- MLS006010416
- SCHEMBL109333
- CHEBI:32151
- HY-A0002R
- DTXSID30947075
- RXZMMZZRUPYENV-VROPFNGYSA-N
- GLXC-02947
- HMS3887A13
- SOLIFENACIN SUCCINATE [MI]
- SOLIFENACIN SUCCINATE [JAN]
- EX-A4170
- HY-A0002
- Solifenacin (Succinate) (Standard)
- MFCD00954234
- s3048
- SOLIFENACIN SUCCINATE [VANDF]
- AKOS015994745
- SOLIFENACIN SUCCINATE [WHO-DD]
- CCG-269551
- CS-0371
- KS-1286
- Solifenacin succinate (JAN/USAN/INN)
- quinuclidin-3'-yl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate monosuccinate
- Solifenacin succinate, >=98% (HPLC)
- 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-1-phenyl-, (3R)-1-azabicyclo(2.2.2)oct-3-yl ester, (1S)-, butanedioate (1:1)
- AS-35288
- BS164410
- Butanedioic acid, cmpd. with (1S)-(3R)-1-azabicyclo(2.2.2)oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate (1:1)
- Butanedioic acid, compd with (1S)-(3R)-1-azabicyclo(2.2.2)oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate (1:1)
- SMR004701445
- YM-53705
- SOLIFENACIN SUCCINATE [ORANGE BOOK]
- S0944
- SW219141-1
- D01269
- SBI-0654098.0001
- Q374826
- Solifenacin succinate, EuropePharmacopoeia (EP) Reference Standard
- Solifenacin Succinate, United States Pharmacopeia (USP) Reference Standard
- (3R)-Quinuclidin-3-yl (1S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate succinate
- (S)-(R)-Quinuclidin-3-yl1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylatesuccinate
- Solifenacin for system suitability, EuropePharmacopoeia (EP) Reference Standard
- (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl-3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate succinate
- Butanedioic acid--1-azabicyclo[2.2.2]octan-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate (1/1)
P264, P270, P301+P317, P330, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 68 reports by companies from 11 notifications to the ECHA C&L Inventory.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
◉ Summary of Use during Lactation
Because there is no published experience with solifenacin during breastfeeding and it has a long half-life averaging 55 hours, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Long-term use of solifenacin might reduce milk production or milk letdown. During long-term use, observe the infant for signs of decreased milk production (e.g., insatiety, poor weight gain) and for anticholinergic symptoms (e.g., constipation, urinary retention, UTI, dry mouth).
◉ Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk
Anticholinergics can inhibit lactation in animals, apparently by inhibiting growth hormone and oxytocin secretion. Anticholinergic drugs can also reduce serum prolactin in nonnursing women. The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=RXZMMZZRUPYENV-VROPFNGYSA-N
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/Solifenacin succinatehttps://commonchemistry.cas.org/detail?cas_rn=242478-38-2
- ChemIDplusSolifenacin succinate [USAN]https://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0242478382ChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- EPA DSSToxButanedioic acid--1-azabicyclo[2.2.2]octan-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate (1/1)https://comptox.epa.gov/dashboard/DTXSID30947075CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
- European Chemicals Agency (ECHA)LICENSEUse of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.https://echa.europa.eu/web/guest/legal-notice(+)-(1S,3’R)-quinuclidin-3’-yl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate monosuccinatehttps://echa.europa.eu/substance-information/-/substanceinfo/100.149.369(+)-(1S,3’R)-quinuclidin-3’-yl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate monosuccinate (EC: 620-505-5)https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/153825
- FDA Global Substance Registration System (GSRS)LICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linkingSOLIFENACIN SUCCINATEhttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/KKA5DLD701
- CCSbaseCCSbase Classificationhttps://ccsbase.net/
- ChEBISolifenacin succinatehttps://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:32151
- Open TargetsLICENSEDatasets generated by the Open Targets Platform are freely available for download.https://platform-docs.opentargets.org/licenceSOLIFENACIN SUCCINATEhttps://platform.opentargets.org/drug/CHEMBL1200803
- ChEMBLLICENSEAccess to the web interface of ChEMBL is made under the EBI's Terms of Use (http://www.ebi.ac.uk/Information/termsofuse.html). The ChEMBL data is made available on a Creative Commons Attribution-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-sa/3.0/).http://www.ebi.ac.uk/Information/termsofuse.htmlChEMBL Protein Target Treehttps://www.ebi.ac.uk/chembl/g/#browse/targets
- Comparative Toxicogenomics Database (CTD)LICENSEIt is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.http://ctdbase.org/about/legal.jspSolifenacin Succinatehttps://ctdbase.org/detail.go?type=chem&acc=D000069464
- Drug Gene Interaction database (DGIdb)LICENSEThe data used in DGIdb is all open access and where possible made available as raw data dumps in the downloads section.http://www.dgidb.org/downloadsSOLIFENACIN SUCCINATEhttps://www.dgidb.org/drugs/rxcui:476588
- ClinicalTrials.govLICENSEThe ClinicalTrials.gov data carry an international copyright outside the United States and its Territories or Possessions. Some ClinicalTrials.gov data may be subject to the copyright of third parties; you should consult these entities for any additional terms of use.https://clinicaltrials.gov/ct2/about-site/terms-conditions#Use
- DailyMed
- Drugs and Lactation Database (LactMed)
- Drugs@FDALICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linking
- European Medicines Agency (EMA)LICENSEInformation on the European Medicines Agency's (EMA) website is subject to a disclaimer and copyright and limited reproduction notices.https://www.ema.europa.eu/en/about-us/legal-noticeSolifenacin (succinate) (P/0115/2015)https://www.ema.europa.eu/en/medicines/human/paediatric-investigation-plans/emea-000573-pip02-13-m03
- EU Clinical Trials Register
- FDA Orange BookLICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linking
- KEGGLICENSEAcademic users may freely use the KEGG website. Non-academic use of KEGG generally requires a commercial licensehttps://www.kegg.jp/kegg/legal.htmlTherapeutic category of drugs in Japanhttp://www.genome.jp/kegg-bin/get_htext?br08301.kegUSP drug classificationhttp://www.genome.jp/kegg-bin/get_htext?br08302.kegAnatomical Therapeutic Chemical (ATC) classificationhttp://www.genome.jp/kegg-bin/get_htext?br08303.kegTarget-based classification of drugshttp://www.genome.jp/kegg-bin/get_htext?br08310.keg
- National Drug Code (NDC) DirectoryLICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linkingSOLIFENACIN SUCCINATEhttps://www.fda.gov/drugs/drug-approvals-and-databases/national-drug-code-directory
- NCI Thesaurus (NCIt)LICENSEUnless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.https://www.cancer.gov/policies/copyright-reuseNCI Thesaurushttps://ncit.nci.nih.gov
- NIPH Clinical Trials Search of Japan
- NLM RxNorm TerminologyLICENSEThe RxNorm Terminology is created by the National Library of Medicine (NLM) and is in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from NLM. Credit to the U.S. National Library of Medicine as the source is appreciated but not required. The full RxNorm dataset requires a free license.https://www.nlm.nih.gov/research/umls/rxnorm/docs/termsofservice.htmlsolifenacin succinatehttps://rxnav.nlm.nih.gov/id/rxnorm/476588
- PharmGKBLICENSEPharmGKB data are subject to the Creative Commons Attribution-ShareALike 4.0 license (https://creativecommons.org/licenses/by-sa/4.0/).https://www.pharmgkb.org/page/policies
- SpectraBaseSolifenacin succinatehttps://spectrabase.com/spectrum/4dWFht48k9i
- Springer Nature
- Wikidatasolifenacin succinatehttps://www.wikidata.org/wiki/Q374826
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.htmlSolifenacin Succinatehttps://www.ncbi.nlm.nih.gov/mesh/2010001Muscarinic Antagonistshttps://www.ncbi.nlm.nih.gov/mesh/68018727Urological Agentshttps://www.ncbi.nlm.nih.gov/mesh/68064804
- PubChem
- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 389219073https://pubchem.ncbi.nlm.nih.gov/substance/389219073