Rizatriptan
- rizatriptan
- 144034-80-0
- Risatriptan
- MK 462 free base
- 2-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1H-indol-3-yl)-N,N-dimethylethanamine
- Create:2005-03-25
- Modify:2024-12-27
- L 705,126
- L 705126
- L-705,126
- L-705126
- Maxalt
- MK 0462
- MK 462
- MK-0462
- MK-462
- N,N-dimethyl-2-(5-(1,2,4-triazol-1-ylmethyl)-1H-indole-3-yl)ethylamine
- rizatriptan
- rizatriptan benzoate
- rizatriptan
- 144034-80-0
- Risatriptan
- MK 462 free base
- 2-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1H-indol-3-yl)-N,N-dimethylethanamine
- rizatriptanum
- 1H-Indole-3-ethanamine, N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-
- N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine
- N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine
- MK-462 FREE BASE
- Rizatriptan (INN)
- UNII-51086HBW8G
- DTXSID2023565
- CHEBI:48273
- 51086HBW8G
- N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine
- CHEMBL905
- DIMETHYL({2-[5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1H-INDOL-3-YL]ETHYL})AMINE
- DTXCID103565
- N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]-ethanamine
- NCGC00095899-01
- RIZATRIPTAN [INN]
- Rizatriptan [INN:BAN]
- Rizatriptan benzoat
- L-705126
- N,N-dimethyl-2-(5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl)-ethanamine
- N,N-dimethyl-2-(5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl)ethanamine
- RIZATRIPTAN [MI]
- GTPL51
- RIZATRIPTAN [VANDF]
- SCHEMBL26662
- RIZATRIPTAN [WHO-DD]
- MLS006010229
- BIDD:GT0361
- SPECTRUM1505189
- N02CC04
- BCP28039
- Tox21_111534
- BDBM50033437
- STL484039
- AKOS015896596
- AC-1712
- DB00953
- NCGC00095899-04
- NCGC00095899-09
- NCGC00095899-15
- DS-15263
- SMR000469172
- SBI-0206745.P001
- DB-080717
- CAS-144034-80-0
- NS00014357
- D08485
- AB00698277-05
- AB00698277-07
- AB00698277_08
- AB00698277_09
- EN300-7382446
- L000812
- Q212171
- Q-201675
- BRD-K75699339-057-03-2
- BRD-K75699339-057-07-3
- BRD-K75699339-057-08-1
- BRD-K75699339-057-09-9
- Dimethyl-[2-(5-[1,2,4]triazol-1-ylmethyl-1H-indol-3-yl)-ethyl]-amine
- N,N-dimethyl-2-(5-(1,2,4-triazol-1-ylmethyl)-1H-indole-3-yl)ethylamine
- N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1h-indol-3-yl] ethylamine
- dimethyl(2-{5-[(1H-1,2,4-triazol-1-yl)methyl]-1H-indol-3-yl}ethyl)amine
- 2-(5-((1H-1,2,4-triazol-1-yl)methyl)-1H-indol-3-yl)-N,N-dimethylethanamine;N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine
201.139435 52328
158.097137 19980
202.142273 6904
156.080536 6096
270.171387 3988
201.139435 100
158.097137 38.18
202.142273 13.19
156.080536 11.65
270.171387 7.62
201.13844 100
158.09634 56.44
58.06588 27.26
270.17093 6.99
225.11298 2.99
158.09778 100
201.13855 64.30
58.06653 51.23
156.08028 20.32
143.07326 12.19
- Rizatriptan Benzoate (has salt form)
- Rizatriptan Sulfate (has salt form)
- Cytoplasm
- Membrane
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H336 (100%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]
H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
P203, P260, P261, P264, P264+P265, P270, P271, P280, P304+P340, P305+P351+P338, P318, P319, P337+P317, P403+P233, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Eye Irrit. 2 (100%)
STOT SE 3 (100%)
Repr. 2 (100%)
STOT RE 1 (100%)
M Chen, V Vijay, Q Shi, Z Liu, H Fang, W Tong. FDA-Approved Drug Labeling for the Study of Drug-Induced Liver Injury, Drug Discovery Today, 16(15-16):697-703, 2011. PMID:21624500 DOI:10.1016/j.drudis.2011.05.007
M Chen, A Suzuki, S Thakkar, K Yu, C Hu, W Tong. DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug Discov Today 2016, 21(4): 648-653. PMID:26948801 DOI:10.1016/j.drudis.2016.02.015
◉ Summary of Use during Lactation
Breastmilk levels of rizatriptan are low and the half-life in milk is relatively short. Amounts ingested by the infant are small and unlikely to affect the nursing infant. Painful, burning nipples and breast pain have been reported after doses of sumatriptan and other triptans. This has occasionally been accompanied by a decrease in milk production.
◉ Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk
A review of four European adverse reaction databases found 26 reported cases of, painful, burning nipples, painful breasts, breast engorgement and/or painful milk ejection in women who took a triptan while nursing. Pain was sometimes intense and occasionally led to decreased milk production. Pain generally subsided with time as the drug was eliminated. The authors proposed that triptans may cause vasoconstriction of the arteries in the breast, nipples, and the arteries surrounding the alveoli and milk ducts, causing a painful sensation and a painful milk ejection reflex.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=ULFRLSNUDGIQQP-UHFFFAOYSA-N
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