Riociguat
- Riociguat
- 625115-55-1
- Adempas
- BAY 63-2521
- Riociguat (BAY 63-2521)
- Create:2006-10-26
- Modify:2025-01-11
- Adempas
- BAY 63-2521
- BAY-63-2521
- riociguat
- Riociguat
- 625115-55-1
- Adempas
- BAY 63-2521
- Riociguat (BAY 63-2521)
- riociguatum
- UNII-RU3FE2Y4XI
- RU3FE2Y4XI
- Methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate
- BAY-63-2521
- 1304478-72-5
- CHEBI:76018
- methyl N-(4,6-diamino-2-{1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate
- methyl N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]-N-methylcarbamate
- N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methylcarbamic acid methyl ester
- RIOCIGUAT (USP-RS)
- RIOCIGUAT [USP-RS]
- Methyl 4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)-5-pyrimidinyl(methyl)carbamate
- Methyl N-(4,6-diamino-2-{1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl}pyrimidin-5-yl)-N-methylcarbamate
- RIOCIGUAT (EP MONOGRAPH)
- RIOCIGUAT [EP MONOGRAPH]
- RIOCIGUAT (USP MONOGRAPH)
- RIOCIGUAT [USP MONOGRAPH]
- Riociguat [INN]
- Carbamic acid, (4,6-diamino-2-(1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)-5-pyrimidinyl)methyl-, methyl ester
- Carbamic acid, N-(4,6-diamino-2-(1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)-5-pyrimidinyl)-N-methyl-, methyl ester
- methyl ~{N}-[4,6-bis(azanyl)-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]-~{N}-methyl-carbamate
- Riociguate
- Riociguat [USAN:INN:JAN]
- C20H19FN8O2
- Riocguat-d3
- GZO
- methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)pyrimidin-5-yl)methylcarbamate
- methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamate
- Methyl 4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl(methyl)carbamate
- Methyl N-(4,6-Diamino-2-(1-((2-fluorophenyl)methyl)-1H-pyrazolo(3,4-b)pyridin-3-yl)-5-pyrimidinyl)-N-methyl-carbaminate
- METHYL N-(4,6-DIAMINO-2-(1-((2-FLUOROPHENYL)METHYL)-1H-PYRAZOLO(3,4-B)PYRIDIN-3-YL)PYRIMIDIN-5-YL)-N-METHYLCARBAMATE
- Methyl N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methyl-carbaminate
- Adempas (TN)
- MFCD19443708
- Riociguat (Standard)
- RIOCIGUAT [JAN]
- RIOCIGUAT [MI]
- RIOCIGUAT [USAN]
- RIOCIGUAT [VANDF]
- RIOCIGUAT [WHO-DD]
- Bay 63-2521,Riociguat
- Riociguat (JAN/USAN/INN)
- SCHEMBL245457
- GTPL5257
- RIOCIGUAT [ORANGE BOOK]
- CHEMBL2107834
- C02KX05
- DTXSID50978109
- WXXSNCNJFUAIDG-UHFFFAOYSA-N
- GLXC-15785
- Riociguat (BAY 63-2521)?
- BCP04750
- BCP23980
- EX-A2023
- Riociguat,CAS:625115-55-1
- HY-14779R
- s8135
- AKOS015900718
- AKOS032950011
- BAY-632521
- BCP9000382
- CCG-268912
- CS-0584
- DB08931
- PB25734
- NCGC00379065-03
- NCGC00379065-04
- NCGC00379065-05
- AC-27647
- AS-19299
- HY-14779
- methyl N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]-N-methyl-carbamate
- BCP0726000023
- DB-073136
- NS00069317
- D09572
- BAY 63-2521; BAY 632521
- EN300-7413126
- Q2154494
- BRD-K84783599-001-01-0
- BAY 63-2521-d3; BAY 632521-d3; Methyl [4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]methylcarbamate-d3
P264, P270, P301+P317, P330, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 25 reports by companies from 1 notifications to the ECHA C&L Inventory.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
In preregistration studies, riociguat was not associated with serum enzyme elevations or with episodes of clinically apparent liver injury. Since approval of riociguat, there have been no published reports of hepatotoxicity, and the product label does not mention liver injury as an adverse event.
Likelihood score: E (unlikely cause of clinically apparent liver injury).
◉ Summary of Use during Lactation
No information is available on the clinical use of riociguat during breastfeeding. The manufacturer recommends that breastfeeding be avoided during riociguat use. The drug should be absent from breastmilk 3 days after the last dose.
◉ Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=WXXSNCNJFUAIDG-UHFFFAOYSA-N
- Avoid St. John's Wort. This herb induces the CYP3A4 metabolism of riociguat and may reduce its serum concentration.
- Take separate from antacids. Take at least 1 hour before or after antacids. Aluminum or magnesium hydroxide antacids may reduce riociguat absorption.
- Take with or without food.
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