Isophorone
- ISOPHORONE
- 78-59-1
- Isoacetophorone
- 3,5,5-Trimethylcyclohex-2-en-1-one
- Isoforone
- Create:2005-03-26
- Modify:2025-01-11
- diisophorone
- isophorone
- ISOPHORONE
- 78-59-1
- Isoacetophorone
- 3,5,5-Trimethylcyclohex-2-en-1-one
- Isoforone
- 3,5,5-Trimethyl-2-cyclohexen-1-one
- 3,5,5-Trimethylcyclohex-2-enone
- Isooctopherone
- Isoforon
- Izoforon
- alpha-Isophorone
- 2-Cyclohexen-1-one, 3,5,5-trimethyl-
- Isophoron
- .alpha.-Isophoron
- 1,1,3-Trimethyl-3-cyclohexene-5-one
- .alpha.-Isophorone
- Caswell No. 506
- 3,5,5-Trimethyl-2-cyclohexenone
- FEMA No. 3553
- NCI-C55618
- 3,5,5-Trimethyl-2-cyclohexen-1-on
- CCRIS 1353
- HSDB 619
- ISOPHORONE, REAG
- NSC 403657
- a-Isophorone
- UNII-2BR99VR6WA
- EINECS 201-126-0
- 2BR99VR6WA
- 3,5,5-Trimetil-2-cicloesen-1-one
- 3,5,5-Trimethylcyclohexenone
- Isophorone, 97%
- EPA Pesticide Chemical Code 047401
- BRN 1280721
- ISOACETOPHORON
- nchem.180-comp3
- 3,5,5-Trimethylcyclohexen one
- DTXSID8020759
- CHEBI:34800
- AI3-00046
- ISOPHORONE [MI]
- ISOPHORONE [FHFI]
- ISOPHORONE [HSDB]
- 1,5,5-Trimethyl-1-cyclohexen-3-one
- NSC-403657
- 3,5,5-Trimethyl-2-cyclohexene-1-one
- DTXCID40759
- FEMA 3553
- NSC4881
- EC 201-126-0
- 4-07-00-00165 (Beilstein Handbook Reference)
- 3,5,5-Trimethylcyclohexen-2-one-1
- 3,3,5-Trimethyl-2-cyclohexen-1-one
- 3,5,5-trimethylcyclohex-2-ene-1-one
- 1,1, 3-Trimethyl-3-cyclohexene-5-one
- 3,5, 5-Trimethyl-2-cyclohexene-1-one
- 1,3,3-TRIMETHYLCYLOHEXEN-5-ONE
- 1,5,5-TRIMETHYL-3-OXOCYCLOHEXENE
- Izoforon [Polish]
- 3,5-Trimethyl-2-cyclohexenone
- Isoforone [Italian]
- 3,5-Trimetil-2-cicloesen-1-one
- 3,5-Trimethyl-2-cyclohexen-1-one
- 1,3-Trimethyl-3-cyclohexene-5-one
- 3,5-Trimethyl-2-cyclohexene-1-one
- WLN: L6V BUTJ C1 D1 D1
- 2-Cyclohexen-1-one,5,5-trimethyl-
- CAS-78-59-1
- 3,5-Trimethyl-2-cyclohexen-1-on (GERMAN, DUTCH)
- alpha -isophoron
- alpha -isophorone
- 3,5,5-Trimetil-2-cicloesen-1-one [Italian]
- cyclohexane-1-one
- Caswell no 506
- MFCD00001584
- 3,5,5-Trimethyl-2-cyclohexen-1-on [German, Dutch]
- 3,5,5-Trimethyl-2-cyclo-hexen-1-one
- Isophorone (ACGIH:OSHA)
- Pesticide Code: 047401
- SCHEMBL22522
- Isophorone, >=97%, FG
- 3,5,5Trimethyl2cyclohexenone
- 3,5,5Trimetil2cicloesen1one
- BIDD:ER0627
- 3,5,5Trimethyl2cyclohexen1on
- Isophorone, analytical standard
- 3,5,5Trimethyl2cyclohexen1one
- 1,1,3Trimethyl3cyclohexene5one
- CHEMBL1882894
- 3,5,5-TRIMETHYL-2-
- 2Cyclohexen1one, 3,5,5trimethyl
- 3,5,5-trimethyl-cyclohex-2-enone
- HY-Y0932
- NSC-4881
- Tox21_202312
- Tox21_300050
- BBL027346
- NSC403657
- s2998
- STK801792
- AKOS000120392
- AKOS025243269
- 3,3,5-Trimethyl-5-cyclohexen-1-one
- 3,5,5-trimethylcyclohexa-2-en-1-one
- 3,3,5-trimethyl-cyclohex-5-en-1-one
- 3,5,5-trimethyl-cyclohex-2-en-1-one
- NCGC00164006-01
- NCGC00164006-02
- NCGC00164006-03
- NCGC00254115-01
- NCGC00259861-01
- 3,3,5-trimethyl-cyclohex-5 -en-1-one
- AC-10580
- DA-64558
- VS-08530
- Isophorone, Vetec(TM) reagent grade, 97%
- CS-0015924
- I0151
- NS00005755
- 3,5,5-TRIMETHYL-5-CYCLOHEXEN-1-ONE
- EN300-20384
- D72515
- Q415519
- W-104274
- F0001-2053
- Z104477948
Odor Threshold Low: 0.19 [mmHg]
Odor Threshold High: 0.53 [mmHg]
Detection odor threshold from AIHA (mean = 0.19 ppm)
82.0 99.99
54.0 14.80
138.0 12.20
53.0 6.90
67.0 5.30
139.0 99.99
82.0 34.38
138.0 14.86
140.0 10.08
95.0 3.66
139.1108 100
140.1136 9.85
139.1108 999
140.1136 98
139.1105 999
69.0329 586
82 999
54 148
138 122
53 69
67 53
- Cytoplasm
- Extracellular
- Solvents (which become part of product formulation or mixture)
- Other (specify)
- Intermediates
- Not Known or Reasonably Ascertainable
- Not Known or Reasonably Ascertainable
- Solvents (which become part of product formulation or mixture)
Isophorone as such should not be used as fragrance ingredient.
Natural extracts containing Isophorone should not be used as substitutes for this substance.
2019: 10,000,000 - <50,000,000 lb
2018: 10,000,000 - <50,000,000 lb
2017: 10,000,000 - <50,000,000 lb
2016: 10,000,000 - <50,000,000 lb
- Printing Ink Manufacturing
- Plastics Material and Resin Manufacturing
- Not Known or Reasonably Ascertainable
- All Other Basic Organic Chemical Manufacturing
- Paint and Coating Manufacturing
- Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing
H302 (> 99.9%): Harmful if swallowed [Warning Acute toxicity, oral]
H312 (> 99.9%): Harmful in contact with skin [Warning Acute toxicity, dermal]
H319 (96.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (> 99.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
H351 (> 99.9%): Suspected of causing cancer [Warning Carcinogenicity]
P203, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P318, P319, P321, P330, P337+P317, P362+P364, P403+P233, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 2246 reports by companies from 28 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Reported as not meeting GHS hazard criteria per 1 of 2246 reports by companies. For more detailed information, please visit ECHA C&L website.
There are 27 notifications provided by 2245 of 2246 reports by companies with hazard statement code(s).
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Acute Tox. 4 (> 99.9%)
Acute Tox. 4 (> 99.9%)
Eye Irrit. 2A (96.1%)
STOT SE 3 (> 99.9%)
Carc. 2 (> 99.9%)
Carcinogenicity - category 2
Acute toxicity - category 4
Acute toxicity - category 4
Eye irritation - category 2A
Specific target organ toxicity (single exposure) - category 3
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
(See general first aid procedures)
Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.
Skin: Soap wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly.
Breathing: Respiratory support
Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.
Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:
CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient. CAUTION: For mixtures containing alcohol or polar solvent, alcohol-resistant foam may be more effective.
SMALL FIRE: Dry chemical, CO2, water spray or regular foam. If regular foam is ineffective or unavailable, use alcohol-resistant foam.
LARGE FIRE: Water spray, fog or regular foam. If regular foam is ineffective or unavailable, use alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.
FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. For petroleum crude oil, do not spray water directly into a breached tank car. This can lead to a dangerous boil over. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)
Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.
LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:
ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material.
LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)
200.0 [ppm]
Excerpts from Documentation for IDLHs: Basis for original (SCP) IDLH: The chosen IDLH is based on the UCC [1971] report that exposure of animals for 1 hour to 880 ppm caused serious organ damage; only 1 of 6 animals died from an 8hour exposure to air saturated with isophorone (approximately 525 ppm at 77°F). . . . Human data: A few of the 11 or 12 volunteers exposed for a few minutes to 200 or 400 ppm complained of nausea, headache, dizziness, faintness, inebriation, and a feeling of suffocation [Smyth and Seaton 1940].
200 ppm
See: 78591
Excerpt from NIOSH Pocket Guide for Isophorone:
Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.
Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.
Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.
Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced.
Change: No recommendation is made specifying the need for the worker to change clothing after the workshift.
Provide: EYEWASH - Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substances; this is irrespective of the recommendation involving the wearing of eye protection. (NIOSH, 2024)
(See personal protection and sanitation codes)
Skin: Prevent skin contact - Wear appropriate personal protective clothing to prevent skin contact.
Eyes: Prevent eye contact - Wear appropriate eye protection to prevent eye contact.
Wash skin: When contaminated
Remove: When wet or contaminated
Change: No recommendation
Provide: Eyewash - Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substances; this is irrespective of the recommendation involving the wearing of eye protection.
NIOSH
Up to 40 ppm:
(APF = 10) Any chemical cartridge respirator with organic vapor cartridge(s)*
(APF = 10) Any supplied-air respirator*
Up to 100 ppm:
(APF = 25) Any supplied-air respirator operated in a continuous-flow mode*
(APF = 25) Any powered, air-purifying respirator with organic vapor cartridge(s)*
Up to 200 ppm:
(APF = 50) Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s)
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister
(APF = 50) Any powered, air-purifying respirator with a tight-fitting facepiece and organic vapor cartridge(s)*
(APF = 50) Any supplied-air respirator that has a tight-fitting facepiece and is operated in a continuous-flow mode*
(APF = 50) Any self-contained breathing apparatus with a full facepiece
(APF = 50) Any supplied-air respirator with a full facepiece
Emergency or planned entry into unknown concentrations or IDLH conditions:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape:
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister
Any appropriate escape-type, self-contained breathing apparatus
Ketones
Hydrocarbons, Aliphatic Unsaturated
Hazard Traits - Carcinogenicity; Dermatotoxicity; Developmental Toxicity; Hepatotoxicity and Digestive System Toxicity; Neurotoxicity; Respiratory Toxicity
Authoritative List - CA TACs; CWA 303(c); CWA 303(d); IARC Carcinogens - 2B; OEHHA RELs
Report - regardless of intended function of ingredient in the product
Status: Active Update: 24-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/14527
Status: Active Update: 09-03-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/31888
IMAP assessments - 2-Cyclohexen-1-one, 3,5,5-trimethyl-: Human health tier II assessment
IMAP assessments - 2-Cyclohexen-1-one, 3,5,5-trimethyl-: Environment tier I assessment
Neurotoxin - Acute solvent syndrome
Dermatotoxin - Skin burns.
IARC Carcinogen - Class 3: Chemicals are not classifiable by the International Agency for Research on Cancer.
ACGIH Carcinogen - Confirmed Animal.
Solvents, acute toxic effect [Category: Acute Poisoning]
Encephalopathy, chronic solvent [Category: Chronic Poisoning]
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=HJOVHMDZYOCNQW-UHFFFAOYSA-N
- Agency for Toxic Substances and Disease Registry (ATSDR)LICENSEThe information provided using CDC Web site is only intended to be general summary information to the public. It is not intended to take the place of either the written law or regulations.https://www.cdc.gov/Other/disclaimer.html
- EPA Integrated Risk Information System (IRIS)
- The National Institute for Occupational Safety and Health (NIOSH)LICENSEThe information provided using CDC Web site is only intended to be general summary information to the public. It is not intended to take the place of either the written law or regulations.https://www.cdc.gov/Other/disclaimer.html2-Cyclohexen-1-one, 3,5,5-trimethyl-https://www.cdc.gov/niosh-rtecs/GW757E20.html
- EPA Air Toxics
- Haz-Map, Information on Hazardous Chemicals and Occupational DiseasesLICENSECopyright (c) 2022 Haz-Map(R). All rights reserved. Unless otherwise indicated, all materials from Haz-Map are copyrighted by Haz-Map(R). No part of these materials, either text or image may be used for any purpose other than for personal use. Therefore, reproduction, modification, storage in a retrieval system or retransmission, in any form or by any means, electronic, mechanical or otherwise, for reasons other than personal use, is strictly prohibited without prior written permission.https://haz-map.com/AboutIsophoronehttps://haz-map.com/Agents/142
- CAMEO ChemicalsLICENSECAMEO Chemicals and all other CAMEO products are available at no charge to those organizations and individuals (recipients) responsible for the safe handling of chemicals. However, some of the chemical data itself is subject to the copyright restrictions of the companies or organizations that provided the data.https://cameochemicals.noaa.gov/help/reference/terms_and_conditions.htm?d_f=falseCAMEO Chemical Reactivity Classificationhttps://cameochemicals.noaa.gov/browse/react
- ChEBI
- LOTUS - the natural products occurrence databaseLICENSEThe code for LOTUS is released under the GNU General Public License v3.0.https://lotus.nprod.net/Isophoronehttps://www.wikidata.org/wiki/Q415519LOTUS Treehttps://lotus.naturalproducts.net/
- Australian Industrial Chemicals Introduction Scheme (AICIS)2-Cyclohexen-1-one, 3,5,5-trimethyl-https://services.industrialchemicals.gov.au/search-assessments/2-Cyclohexen-1-one, 3,5,5-trimethyl-https://services.industrialchemicals.gov.au/search-inventory/
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/
- ChemIDplusChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- DTP/NCILICENSEUnless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.https://www.cancer.gov/policies/copyright-reuse
- EPA Chemical Data Reporting (CDR)LICENSEThe U.S. Government retains a nonexclusive, royalty-free license to publish or reproduce these documents, or allow others to do so, for U.S. Government purposes. These documents may be freely distributed and used for non-commercial, scientific and educational purposes.https://www.epa.gov/web-policies-and-procedures/epa-disclaimers#copyright2-Cyclohexen-1-one, 3,5,5-trimethyl-https://www.epa.gov/chemical-data-reporting
- EPA Chemicals under the TSCA2-Cyclohexen-1-one, 3,5,5-trimethyl-https://www.epa.gov/chemicals-under-tscaEPA TSCA Classificationhttps://www.epa.gov/tsca-inventory
- EPA DSSToxCompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
- European Chemicals Agency (ECHA)LICENSEUse of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.https://echa.europa.eu/web/guest/legal-notice3,5,5-trimethylcyclohex-2-enonehttps://chem.echa.europa.eu/100.001.0243,5,5-trimethylcyclohex-2-enone (EC: 201-126-0)https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/56300
- FDA Global Substance Registration System (GSRS)LICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linking
- Hazardous Substances Data Bank (HSDB)
- Human Metabolome Database (HMDB)LICENSEHMDB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (HMDB) and the original publication (see the HMDB citing page). We ask that users who download significant portions of the database cite the HMDB paper in any resulting publications.http://www.hmdb.ca/citing3,5,5-Trimethyl-2-cyclohexen-1-onehttp://www.hmdb.ca/metabolites/HMDB0031195HMDB0031195_cms_100605https://hmdb.ca/metabolites/HMDB0031195#spectra
- ILO-WHO International Chemical Safety Cards (ICSCs)
- New Zealand Environmental Protection Authority (EPA)LICENSEThis work is licensed under the Creative Commons Attribution-ShareAlike 4.0 International licence.https://www.epa.govt.nz/about-this-site/general-copyright-statement/2-Cyclohexen-1-one, 3,5,5-trimethyl-https://www.epa.govt.nz/industry-areas/hazardous-substances/guidance-for-importers-and-manufacturers/hazardous-substances-databases/
- NJDOH RTK Hazardous Substance List
- Occupational Safety and Health Administration (OSHA)LICENSEMaterials created by the federal government are generally part of the public domain and may be used, reproduced and distributed without permission. Therefore, content on this website which is in the public domain may be used without the prior permission of the U.S. Department of Labor (DOL). Warning: Some content - including both images and text - may be the copyrighted property of others and used by the DOL under a license.https://www.dol.gov/general/aboutdol/copyrightISOPHORONEhttps://www.osha.gov/chemicaldata/673
- Risk Assessment Information System (RAIS)LICENSEThis work has been sponsored by the U.S. Department of Energy (DOE), Office of Environmental Management, Oak Ridge Operations (ORO) Office through a joint collaboration between United Cleanup Oak Ridge LLC (UCOR), Oak Ridge National Laboratory (ORNL), and The University of Tennessee, Ecology and Evolutionary Biology, The Institute for Environmental Modeling (TIEM). All rights reserved.https://rais.ornl.gov/
- California Safe Cosmetics Program (CSCP) Product Database
- Joint FAO/WHO Expert Committee on Food Additives (JECFA)LICENSEPermission from WHO is not required for the use of WHO materials issued under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Intergovernmental Organization (CC BY-NC-SA 3.0 IGO) licence.https://www.who.int/about/policies/publishing/copyrightIsophoronehttps://www.fao.org/food/food-safety-quality/scientific-advice/jecfa/jecfa-flav/details/en/c/1044/1,3,3-TRIMETHYLCYLOHEXEN-5-ONEhttps://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/47751,5,5-TRIMETHYL-3-OXOCYCLOHEXENEhttps://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/4779
- ChEMBLLICENSEAccess to the web interface of ChEMBL is made under the EBI's Terms of Use (http://www.ebi.ac.uk/Information/termsofuse.html). The ChEMBL data is made available on a Creative Commons Attribution-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-sa/3.0/).http://www.ebi.ac.uk/Information/termsofuse.html
- Comparative Toxicogenomics Database (CTD)LICENSEIt is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.http://ctdbase.org/about/legal.jsp
- Crystallography Open Database (COD)LICENSEAll data in the COD and the database itself are dedicated to the public domain and licensed under the CC0 License. Users of the data should acknowledge the original authors of the structural data.https://creativecommons.org/publicdomain/zero/1.0/
- EPA Chemical and Products Database (CPDat)EPA CPDat Classificationhttps://www.epa.gov/chemical-research/chemical-and-products-database-cpdat
- EU Food Improvement Agents3,5,5-Trimethylcyclohex-2-en-1-onehttps://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32012R0872
- EPA Regional Screening Levels for Chemical Contaminants at Superfund SitesIsobutyl Alcoholhttps://epa-prgs.ornl.gov/cgi-bin/chemicals/csl_searchIsobutyl Alcoholhttps://epa-prgs.ornl.gov/cgi-bin/chemicals/csl_search?tool=rml
- Hazardous Chemical Information System (HCIS), Safe Work Australia3,5,5-trimethylcyclohex-2-enonehttp://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=23
- NITE-CMC2-Cyclohexen-1-one, 3,5,5-trimethyl- - FY2006 (New/original classication)https://www.chem-info.nite.go.jp/chem/english/ghs/06-imcg-0644e.htmlIsophorone - FY2018 (Revised classification)https://www.chem-info.nite.go.jp/chem/english/ghs/18-moe-2009e.htmlIsophorone; alpha-Isophorone - FY2023 (Revised classification)https://www.chem-info.nite.go.jp/chem/english/ghs/23-jniosh-2021e.html
- Regulation (EC) No 1272/2008 of the European Parliament and of the CouncilLICENSEThe copyright for the editorial content of this source, the summaries of EU legislation and the consolidated texts, which is owned by the EU, is licensed under the Creative Commons Attribution 4.0 International licence.https://eur-lex.europa.eu/content/legal-notice/legal-notice.html3,5,5-trimethylcyclohex-2-enone; isophoronehttps://eur-lex.europa.eu/eli/reg/2008/1272/oj
- FDA Substances Added to FoodLICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linking
- Flavor and Extract Manufacturers Association (FEMA)
- FooDBLICENSEFooDB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (FooDB) and the original publication.https://foodb.ca/about3,5,5-Trimethyl-2-cyclohexen-1-onehttps://foodb.ca/compounds/FDB003216
- NORMAN Suspect List ExchangeLICENSEData: CC-BY 4.0; Code (hosted by ECI, LCSB): Artistic-2.0https://creativecommons.org/licenses/by/4.0/NORMAN Suspect List Exchange Classificationhttps://www.norman-network.com/nds/SLE/
- USGS Health-Based Screening Levels for Evaluating Water-Quality DataLICENSEhttps://www.usgs.gov/legal
- NMRShiftDB
- MassBank Europe3,5,5-TRIMETHYL-2-CYCLOHEXEN-1-ONEhttps://massbank.eu/MassBank/Result.jsp?inchikey=HJOVHMDZYOCNQW-UHFFFAOYSA-N
- MassBank of North America (MoNA)LICENSEThe content of the MoNA database is licensed under CC BY 4.0.https://mona.fiehnlab.ucdavis.edu/documentation/license
- NIST Mass Spectrometry Data CenterLICENSEData covered by the Standard Reference Data Act of 1968 as amended.https://www.nist.gov/srd/public-lawIsophoronehttp://www.nist.gov/srd/nist1a.cfm
- SpectraBase3,5,5-TRIMETHYLCYCLOHEX-2-ENONEhttps://spectrabase.com/spectrum/77NAJTXGNZo3,5,5-TRIMETHYLCYCLOHEX-2-ENONEhttps://spectrabase.com/spectrum/5BS6IDksrBf2-CYCLOHEXEN-1-ONE, 3,5,5-TRIMETHYL-,https://spectrabase.com/spectrum/3hFtDjjHrVq2-CYCLOHEXEN-1-ONE, 3,5,5-TRIMETHYL-https://spectrabase.com/spectrum/HiT0GScJlwR2-Cyclohexen-1-one, 3,5,5-trimethyl-https://spectrabase.com/spectrum/G3cLZCHGTWg2-Cyclohexen-1-one, 3,5,5-trimethyl-https://spectrabase.com/spectrum/58Jn33L4y4k
- International Agency for Research on Cancer (IARC)LICENSEMaterials made available by IARC/WHO enjoy copyright protection under the Berne Convention for the Protection of Literature and Artistic Works, under other international conventions, and under national laws on copyright and neighbouring rights. IARC exercises copyright over its Materials to make sure that they are used in accordance with the Agency's principles. All rights are reserved.https://publications.iarc.fr/Terms-Of-UseIARC Classificationhttps://www.iarc.fr/
- NTP Technical ReportsIsophoronehttps://ntp.niehs.nih.gov/data/tr
- International Fragrance Association (IFRA)LICENSE(c) The International Fragrance Association, 2007-2021. All rights reserved.https://ifrafragrance.org/links/copyright
- Japan Chemical Substance Dictionary (Nikkaji)
- KEGGLICENSEAcademic users may freely use the KEGG website. Non-academic use of KEGG generally requires a commercial licensehttps://www.kegg.jp/kegg/legal.html
- KNApSAcK Species-Metabolite Database
- Natural Product Activity and Species Source (NPASS)3,5,5-Trimethylcyclohex-2-En-1-Onehttps://bidd.group/NPASS/compound.php?compoundID=NPC64866
- Lab and Research Safety, University of MinnesotaIsophorone
- Metabolomics Workbench3,5,5-Trimethyl-2-cyclohexen-1-onehttps://www.metabolomicsworkbench.org/data/StructureData.php?RegNo=44741
- Nature Chemistry
- NIOSH Manual of Analytical MethodsLICENSEThe information provided using CDC Web site is only intended to be general summary information to the public. It is not intended to take the place of either the written law or regulations.https://www.cdc.gov/Other/disclaimer.html
- RCSB Protein Data Bank (RCSB PDB)LICENSEData files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data.https://www.rcsb.org/pages/policies
- Springer Nature
- SpringerMaterials3,5,5-trimethyl-cyclohex-2-enonehttps://materials.springer.com/substanceprofile/docs/smsid_rckkwcyhdnwhvntj
- Thieme ChemistryLICENSEThe Thieme Chemistry contribution within PubChem is provided under a CC-BY-NC-ND 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc-nd/4.0/
- Wikidataisophoronehttps://www.wikidata.org/wiki/Q415519
- WikipediaDipropanoylmorphinehttps://en.wikipedia.org/wiki/DipropanoylmorphineIsophoronehttps://en.wikipedia.org/wiki/Isophorone
- Wiley
- PubChem
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.html
- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
- The Natural Products AtlasLICENSEThe Natural Products Atlas is licensed under a Creative Commons Attribution 4.0 International License.https://www.npatlas.org/termsThe Natural Products Atlas Classificationhttps://www.npatlas.org/
- EPA Substance Registry ServicesEPA SRS List Classificationhttps://sor.epa.gov/sor_internet/registry/substreg/LandingPage.do
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 403029516https://pubchem.ncbi.nlm.nih.gov/substance/403029516
- NCBI