Colestipol
- Colestipol
- 50925-79-6
- Colestipolum
- K50N755924
- Epichlorohydrin-tetraethylenepentamine polymer
- Colestipol
- 50925-79-6
- Colestipolum
- K50N755924
- Epichlorohydrin-tetraethylenepentamine polymer
- CHEBI:3814
- 1,2-Ethanediamine, N-(2-aminoethyl)-N'-(2-((2-aminoethyl)amino)ethyl)-, polymer with (chloromethyl)oxirane
- C10AC02
- COPOLYMER OF DIETHYLENETRIAMINE AND 1-CHLORO-2,3-EPOXYPROPANE
- Colestipolum (INN-Latin)
- Copolymer of bis(2-aminoethyl)amine and 2-(chloromethyl)oxirane
- Epichlorohydrin, polymer with tetraethylenepentamine
- Epichlorohydrin, tetraethylenepentamine polymer
- Epichlorohydrin-tetraethylenepentamine copolymer
- NSC 147003
- NSC-147003
- Oxirane, (chloromethyl)-, polymer with N-(2-aminoethyl)-N'-(2-((2-aminoethyl)amino)ethyl-1,2-ethanediamine
- POLY(EPICHLOROHYDRIN-CO-TETRAETHYLENEPENTAMINE)
- Propane, 1-chloro-2,3-epoxy-, polymer with tetraethylenepentamine
- Tetraethylenepentamine epichlorohydrin polymer
- Tetraethylenepentamine, cross-linked with epichlorohydrin
- Tetraethylenepentamine, polymer with 1-chloro-2,3-epoxypropane
- Tetraethylenepentamine-epichlorohydrin copolymer
- Tetraethylenepentamine-epichlorohydrin polymer
- U 26597A
- UNII-K50N755924
- Epichlorohydrin (has monomer)
- Diethylenetriamine (has monomer)
- Colestipol Hydrochloride (has salt form)
There is little evidence that colestipol causes liver injury. Mild elevations in serum aminotransferase and alkaline phosphatase levels have been reported in small numbers of patients on bile acid resins, although the elevations have been mild, transient and without accompanying symptoms. In addition, a case report of more marked aminotransferase elevations (>10 times ULN) with rapid recovery on stopping colestipol has been published, but the mechanism by which it might cause hepatotoxicity is very unclear. Colestipol is used in patients with liver disease to treat pruritus, and has little or no effect on serum enzyme or bilirubin levels.
Likelihood score: E (unlikely cause of clinically apparent liver injury with jaundice).
M Chen, V Vijay, Q Shi, Z Liu, H Fang, W Tong. FDA-Approved Drug Labeling for the Study of Drug-Induced Liver Injury, Drug Discovery Today, 16(15-16):697-703, 2011. PMID:21624500 DOI:10.1016/j.drudis.2011.05.007
M Chen, A Suzuki, S Thakkar, K Yu, C Hu, W Tong. DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug Discov Today 2016, 21(4): 648-653. PMID:26948801 DOI:10.1016/j.drudis.2016.02.015
◉ Summary of Use during Lactation
Colestipol is a nonabsorbable resin. Because it does not enter the mother's bloodstream, it will not reach the infant via breastmilk. It is acceptable for use during lactation.
◉ Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
- Drink plenty of fluids. The tablet and granule formulations must be taken with plenty of water or other fluids.
- Take with food.
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