Isoeugenol
- Isoeugenol
- 97-54-1
- (E)-Isoeugenol
- trans-Isoeugenol
- 2-Methoxy-4-propenylphenol
- Create:2004-09-16
- Modify:2025-01-11
- 2-methoxy-4-propenylphenol
- isoeugenol
- isoeugenol, (E)-isomer
- isoeugenol, (Z)-isomer
- isoeugenol, sodium salt
- Isoeugenol
- 97-54-1
- (E)-Isoeugenol
- trans-Isoeugenol
- 2-Methoxy-4-propenylphenol
- 4-Propenylguaiacol
- 2-methoxy-4-(prop-1-en-1-yl)phenol
- 5932-68-3
- 4-Hydroxy-3-methoxy-1-propenylbenzene
- Isoeugenol trans-form
- trans-p-Propenylquaiacol
- 4-Hydroxy-3-methoxypropenylbenzene
- (E)-2-Methoxy-4-(prop-1-enyl)phenol
- 2-METHOXY-4-(1-PROPENYL)PHENOL
- Phenol, 2-methoxy-4-propenyl-
- Phenol, 2-methoxy-4-(1-propenyl)-
- 1-Hydroxy-2-methoxy-4-propenylbenzene
- trans-2-Methoxy-4-propenylphenol
- 2-methoxy-4-[(E)-prop-1-enyl]phenol
- Propenylguaiacol
- Isoeugenol (I)
- 2-methoxy-4-[(1E)-prop-1-en-1-yl]phenol
- 1-Hydroxy-2-methoxy-4-propen-1-ylbenzene
- Propenylgualacol
- Iso-eugenol
- NCI-C60979
- 3-Methoxy-4-hydroxypropenylbenzene
- 3-Methoxy-4-hydroxy-1-propen-1-ylbenzene
- NSC 6769
- Phenol, 2-methoxy-4-propenyl-, (E)-
- Isoeugenol and isomers
- CHEBI:50545
- 1-(3-Methoxy-4-hydroxyphenyl)-1-propene
- 4-Hydroxy-3-methoxy-1-propen-1-ylbenzene
- Phenol, 2-methoxy-4-(1-propenyl)-, (E)-
- trans-4-Propenylgualacol
- 28FSR1NAY4
- CHEMBL193598
- Isoeugenol,c&t
- (E)-2-Methoxy-4-(prop-1-en-1-yl)phenol
- NSC-209522
- 2-Methoxy-4-[(1E)-1-propenyl]phenol
- NCGC00091470-02
- Phenol, 2-methoxy-4-(1-propen-1-yl)-
- Isoeugenol,predominantly trans
- DTXCID502413
- 2-Methoxy-4-[1-propenyl]phenol
- UIL135434
- 3-Methoxy-4-hydroxy-1-propenylbenzene
- CAS-97-54-1
- CCRIS 744
- FEMA No. 2468
- 2-methoxy-4-propenyl-Phenol
- EINECS 202-590-7
- EINECS 227-678-2
- UNII-28FSR1NAY4
- DTXSID7022413
- NSC 209522
- BRN 1909602
- BRN 2046156
- isougenol
- UNII-5M0MWY797U
- isoeugenol fcc
- isoeugenol tech
- e-isoeugenol
- 1-(3-Methoxy-4-hydroxyphenyl)-1-propane
- Iso eugenol
- AI3-15356
- Isoeugenol E
- Isoeugenol Z
- HSDB 8044
- iso-Eugenol 2
- isoeugenol 916
- MFCD00009285
- CHISOEUG
- iso eugenol 88%+
- Isoeugenol (Standard)
- isoeugenol extra nat us
- Phenol, (E)-
- Phenol, 2-methoxy-4-(1E)-1-propenyl-
- ISOEUGENOL, E-
- Isoeugenol, cis + trans
- ISOEUGENOL, TRANS-
- bmse010052
- ISOEUGENOL, (E)-
- IE TRANS 92
- SCHEMBL57986
- 3-06-00-04993 (Beilstein Handbook Reference)
- MLS001065576
- BIDD:ER0697
- WLN: 2U1R DQ CO1
- Isoeugenol, analytical standard
- Isoeugenol, predominantly trans
- 5M0MWY797U
- (E)-4-PROPENYLGUAIACOL
- HY-N1952R
- Isoeugenol, natural, 99%, FG
- DTXSID50872350
- NSC6769
- HMS2268O09
- WLN: 2U1R DQ CO1 -E
- (E)-2-methoxy-4-propenyl-Phenol
- 2-methoxy-4-(1-propenyl)-Phenol
- ISOEUGENOL TRANS-FORM [MI]
- HY-N1952
- NSC-6769
- Tox21_111138
- Tox21_202433
- Tox21_300303
- BDBM50548724
- NSC209522
- s5757
- STL264281
- AKOS000120575
- Tox21_111138_1
- DB14188
- trans-2-methoxy-4-(1-propenyl)phenol
- (E)-2-methoxy-4-(1-propenyl)-Phenol
- 2-Methoxy-4-propenylphenol (isoeugenol)
- NCGC00091470-01
- NCGC00091470-03
- NCGC00091470-04
- NCGC00091470-05
- NCGC00254142-01
- NCGC00259982-01
- (E)-2-methoxy-4- (1-propenyl)-Phenol
- AC-34996
- AS-61702
- SMR000112408
- (E)-2-Methoxy-4-(1-propen-1-yl)phenol
- DB-290080
- Isoeugenol 2000 microg/mL in Acetonitrile
- CS-0018270
- I0132
- NS00012699
- (E)-2-METHOXY-4-(1-PROPENYL)PHENOL
- EN300-18429
- 2-methoxy-4-(1-propenyl)phenol (ACD/Name 4.0)
- Isoeugenol, predominantly trans, analytical standard
- Q27889971
- Z57953030
- F1905-7039
164.0 99.99
77.0 22.10
55.0 21
103.0 17.60
131.0 16.70
164.0 99.99
149.0 36.50
55.0 27.50
103.0 26.50
77.0 25.50
137.0592 43.86
133.0643 39.73
105.0693 12.36
150.067 2.14
109.0643 1.18
105.0 95.47
115.1 1.88
55.0 1.69
79.1 0.96
41.00111 100
91.05956 75.80
77.03506 53.80
119.04641 48.70
91.07661 11
148.05298 100
163.07651 5.90
Reported Uses:
Table: Reported uses (ppm): (FEMA, 1994)
- Fragrance
- Flavoring and nutrient
Information on 89 consumer products that contain Isoeugenol in the following categories is provided:
• Auto Products
• Commercial / Institutional
• Inside the Home
• Personal Care
2019: <1,000,000 lb
2018: <1,000,000 lb
2017: <1,000,000 lb
2016: <1,000,000 lb
- All Other Chemical Product and Preparation Manufacturing
- Food, beverage, and tobacco product manufacturing
- All Other Basic Organic Chemical Manufacturing
H302 (99.5%): Harmful if swallowed [Warning Acute toxicity, oral]
H312 (96.5%): Harmful in contact with skin [Warning Acute toxicity, dermal]
H315 (99.5%): Causes skin irritation [Warning Skin corrosion/irritation]
H317 (99.7%): May cause an allergic skin reaction [Warning Sensitization, Skin]
H319 (99%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (10%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 1973 reports by companies from 33 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Reported as not meeting GHS hazard criteria per 1 of 1973 reports by companies. For more detailed information, please visit ECHA C&L website.
There are 32 notifications provided by 1972 of 1973 reports by companies with hazard statement code(s).
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Acute Tox. 4 (99.5%)
Acute Tox. 4 (96.5%)
Skin Irrit. 2 (99.5%)
Skin Sens. 1A (99.7%)
Eye Irrit. 2 (99%)
STOT SE 3 (10%)
Acute Tox. 4 (98.6%)
Acute Tox. 4 (98.6%)
Skin Irrit. 2 (87.9%)
Skin Sens. 1A (100%)
Eye Irrit. 2 (98.6%)
Acute Tox. 4 (65.7%)
STOT SE 3 (65.7%)
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)
Hydrocarbons, Aliphatic Unsaturated
Phenols and Cresols
Hazard Traits - Carcinogenicity; Fragrance Allergen
Authoritative List - Annex III of the EU Cosmetics Regulation No. 1223/2009 - Fragrance Allergens; IARC Carcinogens - 2B
Report - regardless of intended function of ingredient in the product
IMAP assessments - Isoeugenol and its constituent isomers: Human health tier II assessment
IMAP assessments - Phenol, 2-methoxy-4-(1-propenyl)-: Environment tier I assessment
Under the conditions of these 2-year gavage studies, there was equivocal evidence of carcinogenic activity of isoeugenol in male F344/N rats based on increased incidences of rarely occurring thymoma and mammary gland carcinoma. There was no evidence of carcinogenic activity of isoeugenol in female F344/N rats administered 75, 150, or 300 mg/kg. There was clear evidence of carcinogenic activity of isoeugenol in male B6C3F1 mice based on increased incidences of hepatocellular adenoma, hepatocellular carcinoma, and hepatocellular adenoma or carcinoma (combined). There was equivocal evidence of carcinogenic activity of isoeugenol in female B6C3F1 mice based on increased incidences of histiocytic sarcoma.
Exposure to isoeugenol resulted in nonneoplastic lesions of the nose in male and female rats; of the nose, forestomach, and glandular stomach in male and female mice; and of the kidney in female mice.
Skin Sensitizer - An agent that can induce an allergic reaction in the skin.
IARC Carcinogen - Class 3: Chemicals are not classifiable by the International Agency for Research on Cancer.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=BJIOGJUNALELMI-ONEGZZNKSA-N
- Australian Industrial Chemicals Introduction Scheme (AICIS)Phenol, 2-methoxy-4-(1-propenyl)-https://services.industrialchemicals.gov.au/search-assessments/Phenol, 2-methoxy-4-(1-propenyl)-https://services.industrialchemicals.gov.au/search-inventory/
- CAMEO ChemicalsLICENSECAMEO Chemicals and all other CAMEO products are available at no charge to those organizations and individuals (recipients) responsible for the safe handling of chemicals. However, some of the chemical data itself is subject to the copyright restrictions of the companies or organizations that provided the data.https://cameochemicals.noaa.gov/help/reference/terms_and_conditions.htm?d_f=falseCAMEO Chemical Reactivity Classificationhttps://cameochemicals.noaa.gov/browse/react
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/trans-Isoeugenolhttps://commonchemistry.cas.org/detail?cas_rn=5932-68-3
- ChemIDplusIsoeugenol trans-formhttps://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0005932683ChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- DrugBankLICENSECreative Common's Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/legalcode)https://www.drugbank.ca/legal/terms_of_useIsoeugenolhttps://www.drugbank.ca/drugs/DB14188
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- EPA Chemicals under the TSCAPhenol, 2-methoxy-4-(1-propen-1-yl)-https://www.epa.gov/chemicals-under-tscaEPA TSCA Classificationhttps://www.epa.gov/tsca-inventory
- EPA DSSTox(E)-Isoeugenolhttps://comptox.epa.gov/dashboard/DTXSID50872350CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
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- ChEBI
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- Yeast Metabolome Database (YMDB)E-4-Propenyl-2-methoxyphenolhttps://www.ymdb.ca/compounds/YMDB01677
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- DailyMed
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- EU Food Improvement Agents
- NORMAN Suspect List ExchangeLICENSEData: CC-BY 4.0; Code (hosted by ECI, LCSB): Artistic-2.0https://creativecommons.org/licenses/by/4.0/(E)-IsoeugenolNORMAN Suspect List Exchange Classificationhttps://www.norman-network.com/nds/SLE/
- Hazardous Chemical Information System (HCIS), Safe Work AustraliaPhenol, 2-methoxy-4-(1-propenyl)-http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5423(E)-2-methoxy-4-(prop-1-enyl)phenolhttp://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5743
- NITE-CMCIsoeugenol - FY2011 (New/original classication)https://www.chem-info.nite.go.jp/chem/english/ghs/11-mhlw-0070e.html
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- IUPAC Digitized pKa Datasetphenol, 2-methoxy-4-(1-propenyl)-https://github.com/IUPAC/Dissociation-Constants
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- SpectraBasePHENOL, 2-METHOXY-4-(1-PROPENYL)-https://spectrabase.com/spectrum/D1TnPKyKi1qIsoeugenol<E->https://spectrabase.com/spectrum/1fwe9D2kVctrans-2-METHOXY-4-PROPENYLPHENOLhttps://spectrabase.com/spectrum/8k7N0tyrPXhtrans-2-methoxy-4-propenylphenolhttps://spectrabase.com/spectrum/LAcNDpIUHj0trans-2-METHOXY-4-PROPENYLPHENOLhttps://spectrabase.com/spectrum/1lY303mnGnY2-Methoxy-4-(trans-2-propenyl)-phenolhttps://spectrabase.com/spectrum/2Tbq6oo3Bs1trans-2-METHOXY-4-PROPENYLPHENOLhttps://spectrabase.com/spectrum/LrjrB9Kh9dtISOEUGENOL, TRANS-,https://spectrabase.com/spectrum/ARWlY6lKn1pPhenol, 2-methoxy-4-(1-propenyl)-https://spectrabase.com/spectrum/EIADOi89B40Phenol, 2-methoxy-4-(1-propenyl)-https://spectrabase.com/spectrum/yPE6X8Fd48
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- Japan Chemical Substance Dictionary (Nikkaji)
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- KNApSAcK Species-Metabolite Database
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- Metabolomics Workbench
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- Protein Data Bank in Europe (PDBe)
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- Wikidata(E)-isoeugenolhttps://www.wikidata.org/wiki/Q27889971
- Wikipediaisoeugenolhttps://en.wikipedia.org/wiki/Isoeugenol
- PubChem
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.html
- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 403032604https://pubchem.ncbi.nlm.nih.gov/substance/403032604