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Nickel sulfamate

PubChem CID
83720
Structure
Nickel sulfamate_small.png
Molecular Formula
Synonyms
  • Nickel sulfamate
  • Nickel(II) sulfamate
  • Sulfamic acid, nickel(2+) salt (2:1)
  • nickel(2+);disulfamate
  • EINECS 237-396-1
Molecular Weight
250.87 g/mol
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Dates
  • Create:
    2005-08-08
  • Modify:
    2025-01-11
Description
Nickel sulfamate is a chemical compound of nickel. Nickel is a chemical compound with the atomic number 28. It is found abundantly in nature in laterite ore minerals, such as limonite, garnierite, and pentlandite. Nickel has a biological role and is found in certain enzymes, including urease, hydrogenase, methylcoenzyme M reductase, and carbon monoxide dehydrogenase. (L40, L41)
L40: Wikipedia. Nickel. Last Updated 22 March 2009. http://en.wikipedia.org/wiki/Nickel
L41: ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/toxprofiles/tp15.html

1 Structures

1.1 2D Structure

Chemical Structure Depiction
Nickel sulfamate.png

1.2 3D Status

Conformer generation is disallowed since MMFF94s unsupported element, mixture or salt

2 Names and Identifiers

2.1 Computed Descriptors

2.1.1 IUPAC Name

nickel(2+);disulfamate
Computed by Lexichem TK 2.7.0 (PubChem release 2021.10.14)

2.1.2 InChI

InChI=1S/2H3NO3S.Ni/c2*1-5(2,3)4;/h2*(H3,1,2,3,4);/q;;+2/p-2
Computed by InChI 1.0.6 (PubChem release 2021.10.14)

2.1.3 InChIKey

KERTUBUCQCSNJU-UHFFFAOYSA-L
Computed by InChI 1.0.6 (PubChem release 2021.10.14)

2.1.4 SMILES

NS(=O)(=O)[O-].NS(=O)(=O)[O-].[Ni+2]
Computed by OEChem 2.3.0 (PubChem release 2024.12.12)

2.2 Molecular Formula

H4N2NiO6S2
Computed by PubChem 2.2 (PubChem release 2021.10.14)

2.3 Other Identifiers

2.3.1 CAS

13770-89-3

2.3.3 Deprecated CAS

1333123-32-2

2.3.4 European Community (EC) Number

2.3.5 DSSTox Substance ID

2.3.6 Wikidata

2.3.7 Wikipedia

2.4 Synonyms

2.4.1 Depositor-Supplied Synonyms

3 Chemical and Physical Properties

3.1 Computed Properties

Property Name
Molecular Weight
Property Value
250.87 g/mol
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Hydrogen Bond Donor Count
Property Value
2
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Hydrogen Bond Acceptor Count
Property Value
8
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Rotatable Bond Count
Property Value
0
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Exact Mass
Property Value
249.886420 Da
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Monoisotopic Mass
Property Value
249.886420 Da
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Topological Polar Surface Area
Property Value
183 Ų
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Heavy Atom Count
Property Value
11
Reference
Computed by PubChem
Property Name
Formal Charge
Property Value
0
Reference
Computed by PubChem
Property Name
Complexity
Property Value
79.2
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Isotope Atom Count
Property Value
0
Reference
Computed by PubChem
Property Name
Defined Atom Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Undefined Atom Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Defined Bond Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Undefined Bond Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Covalently-Bonded Unit Count
Property Value
3
Reference
Computed by PubChem
Property Name
Compound Is Canonicalized
Property Value
Yes
Reference
Computed by PubChem (release 2021.10.14)

3.2 Experimental Properties

3.2.1 Physical Description

Liquid
Nickel sulfamate, 50% aqueous solution: blue-green liquid; [MSDSonline]

3.3 Chemical Classes

Metals -> Nickel Compounds, Inorganic

5 Chemical Vendors

6 Drug and Medication Information

6.1 Reported Fatal Dose

1 to 3 grams for an adult human (hexavalent chromium). (A119)
A119: Barceloux DG: Chromium. J Toxicol Clin Toxicol. 1999;37(2):173-94. PMID:10382554

7 Pharmacology and Biochemistry

7.1 Metabolism / Metabolites

Nickel is absorbed mainly through the lungs and gastrointestinal tract. Once in the body it enters the bloodstream, where it binds to albumin, L-histidine, and _2-macroglobulin. Nickel tends to accumulate in the lungs, thyroid, kidney, heart, and liver. Absorbed nickel is excreted in the urine, wherease unabsorbed nickel is excreted in the faeces. (L41)
L41: ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/toxprofiles/tp15.html

8 Use and Manufacturing

8.1 Uses

Sources/Uses
Commercially available in a solution containing 11% nickel; Used for nickel electroforming processes; [Ullmann]

8.1.1 Industry Uses

  • Plating agent
  • Plating agents and surface treating agents

8.1.2 Consumer Uses

Plating agent

8.2 U.S. Production

Aggregated Product Volume

2019: 2,771,294 lb

2018: 3,509,404 lb

2017: 2,957,124 lb

2016: 1,950,057 lb

8.3 General Manufacturing Information

Industry Processing Sectors
  • Electrical Equipment, Appliance, and Component Manufacturing
  • All Other Chemical Product and Preparation Manufacturing
EPA TSCA Commercial Activity Status
Sulfamic acid, nickel(2+) salt (2:1): ACTIVE

9 Safety and Hazards

9.1 Hazards Identification

9.1.1 GHS Classification

1 of 5
View All
Pictogram(s)
Irritant
Health Hazard
Environmental Hazard
Signal
Danger
GHS Hazard Statements

H302+H332 (18.5%): Harmful if swallowed or if inhaled [Warning Acute toxicity, oral; acute toxicity, inhalation]

H302 (66.7%): Harmful if swallowed [Warning Acute toxicity, oral]

H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]

H332 (31.5%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H334 (100%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]

H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]

H350 (90.7%): May cause cancer [Danger Carcinogenicity]

H350i (25.9%): May cause cancer by inhalation [Danger Carcinogenicity]

H360 (90.7%): May damage fertility or the unborn child [Danger Reproductive toxicity]

H360D (30.6%): May damage the unborn child [Danger Reproductive toxicity]

H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]

H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statement Codes

P203, P233, P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+P317, P302+P352, P304+P340, P317, P318, P319, P321, P330, P333+P317, P342+P316, P362+P364, P391, P403, P405, and P501

(The corresponding statement to each P-code can be found at the GHS Classification page.)

ECHA C&L Notifications Summary

Aggregated GHS information provided per 108 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

9.1.2 Hazard Classes and Categories

Acute Tox. 4 (66.7%)

Skin Sens. 1 (100%)

Acute Tox. 4 (31.5%)

Resp. Sens. 1 (100%)

Muta. 2 (100%)

Carc. 1A (90.7%)

Carc. 1A (25.9%)

Repr. 1B (90.7%)

Repr. 1B (30.6%)

STOT RE 1 (100%)

Aquatic Acute 1 (100%)

Aquatic Chronic 1 (100%)

Carcinogenicity - category 1A

Germ cell mutagenicity - category 2

Specific target organ toxicity (repeated exposure) - category 1

Reproductive toxicity - category 1B

Respiratory sensitisation - category 1

Skin irritation - category 2

Skin sensitisation - category 1

Acute toxicity (ingestion) - category 4

Acute toxicity (inhalation) - category 4

Hazardous to the aquatic environment (acute) - category 1

Hazardous to the aquatic environment (chronic) - category 1

9.1.3 Hazards Summary

Harmful if swallowed; May cause skin sensitization; Chronic inhalation of nickel compounds in high concentrations is linked to lung cancer and nasal sinus cancer. [MSDSonline] See Nickel and linked occupational diseases.

9.2 Exposure Control and Personal Protection

9.2.1 Permissible Exposure Limit (PEL)

1.0 [mg/m3], as Ni

9.2.2 Immediately Dangerous to Life or Health (IDLH)

10.0 [mg/m3], as Ni

9.2.3 Threshold Limit Values (TLV)

0.1 [mg/m3], inhalable fraction, as Ni

9.3 Regulatory Information

The Australian Inventory of Industrial Chemicals
Chemical: Sulfamic acid, nickel(2+) salt (2:1)
California Safe Cosmetics Program (CSCP) Reportable Ingredient

Hazard Traits - Carcinogenicity; Reproductive Toxicity; Respiratory Toxicity

Authoritative List - EC Annex VI CMRs - Cat. 1A; EC Annex VI CMRs - Cat. 1B; EC Annex VI Resp. Sens. - Cat. 1

Report - if used as a fragrance or flavor ingredient

REACH Registered Substance
REACH Restricted Substance

Restricted substance: Nickel bis(sulphamidate)

EC: 237-396-1

Restriction condition document: PDF link

New Zealand EPA Inventory of Chemical Status
Sulfamic acid, nickel(2+) salt (2:1): Does not have an individual approval but may be used under an appropriate group standard

9.4 Other Safety Information

Chemical Assessment

IMAP assessments - Water soluble nickel(2+) salts: Environment tier II assessment

IMAP assessments - Soluble nickel compounds (Group 1): Human health tier II assessment

10 Toxicity

10.1 Toxicological Information

10.1.1 Toxicity Summary

Nickel is known to substitute for other essential elements in certain enzmes, such as calcineurin. It is genotoxic, and some nickel compounds have been shown to promote cell proliferation. Nickel has a high affinity for chromatin proteins, particularly histones and protamines. The complexing of nickel ions with heterochromatin results in a number of alterations including condensation, DNA hypermethylation, gene silencing, and inhibition of histone acetylation, which have been shown to disturb gene expression. Nickel has also been shown to alter several transcription factors, including hypoxia-inducible transcription factor, activating transcription factor, and NF-KB transcription factor. There is also evidence that nickel ions inhibit DNA repair, either by directly inhibiting DNA repair enzymes or competing with zinc ions for binding to zinc-finger DNA binding proteins, resulting in structural changes in DNA that prevent repair enzymes from binding. Nickel ions can also complex with a number of cellular ligands including amino acids, peptides, and proteins resulting in the generation of oxygen radicals, which induce base damage, DNA strand breaks, and DNA protein crosslinks. (L41, A40)
A40: King MM, Huang CY: Activation of calcineurin by nickel ions. Biochem Biophys Res Commun. 1983 Aug 12;114(3):955-61. PMID:6311199
L41: ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/toxprofiles/tp15.html

10.1.2 Carcinogen Classification

Carcinogen Classification
1, carcinogenic to humans. (L135)

10.1.3 Health Effects

The most common harmful health effect of nickel in humans is an allergic reaction. This usually manifests as a skin rash, although some people experience asthma attacks. Long term inhahation of nickel causes chronic bronchitis and reduced lung function, as well as damage to the naval cavity. Ingestion of excess nickel results in damage to the stomach, blood, liver, kidneys, and immune system, as well as having adverse effects on reproduction and development. (L41)
L41: ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/toxprofiles/tp15.html

10.1.4 Exposure Routes

Inhalation (L41) ; oral (L41) ; dermal (L41)
L41: ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for nickel. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/toxprofiles/tp15.html

10.1.5 Symptoms

Symptoms of nickel poisoning include headache, nausea, vomiting, dizziness, irritability, and difficulty sleeping, followed by chest pains, sweating, rapid heart beat, and a dry cough. (L42)
L42: Redmond JC (2008). Nickel Poisoning. LoveToKnow. http://safety.lovetoknow.com/Nickel_Poisoning

10.1.6 Adverse Effects

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

Asthma - Reversible bronchoconstriction (narrowing of bronchioles) initiated by the inhalation of irritating or allergenic agents.

10.1.7 Acute Effects

10.1.8 Minimum Risk Level

Intermediate Inhalation: 0.0002 mg/m3 (L134) Chronic Inhalation: 0.00009 mg/m3 (L134)
L134: ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/mrls/

10.1.9 Treatment

Excess exposure to nickel is usually handled by preventing further exposure and symptomatic treatment. Nickel poisoning may also be treated using chelation therapy with sodium diethyldithiocarbamate. (L42)
L42: Redmond JC (2008). Nickel Poisoning. LoveToKnow. http://safety.lovetoknow.com/Nickel_Poisoning

11 Associated Disorders and Diseases

Associated Occupational Diseases with Exposure to the Compound

Contact dermatitis, allergic [Category: Skin Disease]

Asthma, occupational [Category: Airway Disease]

12 Literature

12.1 Consolidated References

12.2 Springer Nature References

12.3 Chemical Co-Occurrences in Literature

12.4 Chemical-Gene Co-Occurrences in Literature

12.5 Chemical-Disease Co-Occurrences in Literature

13 Patents

13.1 Depositor-Supplied Patent Identifiers

13.2 WIPO PATENTSCOPE

13.3 Chemical Co-Occurrences in Patents

13.4 Chemical-Disease Co-Occurrences in Patents

13.5 Chemical-Gene Co-Occurrences in Patents

14 Interactions and Pathways

14.1 Chemical-Target Interactions

15 Classification

15.1 ChemIDplus

15.2 UN GHS Classification

15.3 NORMAN Suspect List Exchange Classification

15.4 EPA DSSTox Classification

15.5 EPA TSCA and CDR Classification

15.6 EPA Substance Registry Services Tree

16 Information Sources

  1. Australian Industrial Chemicals Introduction Scheme (AICIS)
  2. ChemIDplus
    ChemIDplus Chemical Information Classification
    https://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
  3. EPA Chemical Data Reporting (CDR)
    LICENSE
    The U.S. Government retains a nonexclusive, royalty-free license to publish or reproduce these documents, or allow others to do so, for U.S. Government purposes. These documents may be freely distributed and used for non-commercial, scientific and educational purposes.
    https://www.epa.gov/web-policies-and-procedures/epa-disclaimers#copyright
    Sulfamic acid, nickel(2+) salt (2:1)
    https://www.epa.gov/chemical-data-reporting
  4. EPA Chemicals under the TSCA
    Sulfamic acid, nickel(2+) salt (2:1)
    https://www.epa.gov/chemicals-under-tsca
    EPA TSCA Classification
    https://www.epa.gov/tsca-inventory
  5. EPA DSSTox
    Sulfamic acid, nickel(2+) salt (2:1)
    https://comptox.epa.gov/dashboard/DTXSID2065622
    CompTox Chemicals Dashboard Chemical Lists
    https://comptox.epa.gov/dashboard/chemical-lists/
  6. European Chemicals Agency (ECHA)
    LICENSE
    Use of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.
    https://echa.europa.eu/web/guest/legal-notice
  7. New Zealand Environmental Protection Authority (EPA)
    LICENSE
    This work is licensed under the Creative Commons Attribution-ShareAlike 4.0 International licence.
    https://www.epa.govt.nz/about-this-site/general-copyright-statement/
  8. California Safe Cosmetics Program (CSCP) Product Database
  9. Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
    LICENSE
    Copyright (c) 2022 Haz-Map(R). All rights reserved. Unless otherwise indicated, all materials from Haz-Map are copyrighted by Haz-Map(R). No part of these materials, either text or image may be used for any purpose other than for personal use. Therefore, reproduction, modification, storage in a retrieval system or retransmission, in any form or by any means, electronic, mechanical or otherwise, for reasons other than personal use, is strictly prohibited without prior written permission.
    https://haz-map.com/About
  10. Hazardous Chemical Information System (HCIS), Safe Work Australia
  11. NITE-CMC
    Nickel(II) bis(sulfamidate) - FY2021 (Revised classification)
    https://www.chem-info.nite.go.jp/chem/english/ghs/21-mhlw-2069e.html
    Nickel(II) bis(sulfamidate) - FY2015 (New/original classication)
    https://www.chem-info.nite.go.jp/chem/english/ghs/15-mhlw-0131e.html
  12. Regulation (EC) No 1272/2008 of the European Parliament and of the Council
    LICENSE
    The copyright for the editorial content of this source, the summaries of EU legislation and the consolidated texts, which is owned by the EU, is licensed under the Creative Commons Attribution 4.0 International licence.
    https://eur-lex.europa.eu/content/legal-notice/legal-notice.html
    nickel bis(sulfamidate); nickel sulfamate
    https://eur-lex.europa.eu/eli/reg/2008/1272/oj
  13. Springer Nature
  14. Toxin and Toxin Target Database (T3DB)
    LICENSE
    T3DB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (T3DB) and the original publication.
    http://www.t3db.ca/downloads
  15. Wikidata
  16. Wikipedia
  17. PubChem
  18. GHS Classification (UNECE)
  19. NORMAN Suspect List Exchange
    LICENSE
    Data: CC-BY 4.0; Code (hosted by ECI, LCSB): Artistic-2.0
    https://creativecommons.org/licenses/by/4.0/
    NORMAN Suspect List Exchange Classification
    https://www.norman-network.com/nds/SLE/
  20. EPA Substance Registry Services
  21. PATENTSCOPE (WIPO)
CONTENTS