Frovatriptan
- Frovatriptan
- Frova
- 158747-02-5
- Miguard
- Allergo filmtabletten
- Create:2005-08-08
- Modify:2025-01-18
- (+)-(R)-5,6,7,8-tetrahydro-6-(methylamino)carbazole-3-carboxamide succinate (1:1), monohydrate
- 3-methylamino-6-carboxamido-1,2,3,4-tetrahydrocarbazole
- Allegro
- Frova
- frovatriptan
- frovatriptan succinate
- Frovelan
- SB 209509
- VML-251
- VML251
- Frovatriptan
- Frova
- 158747-02-5
- Miguard
- Allergo filmtabletten
- HSDB 7363
- (6R)-6-(methylamino)-6,7,8,9-tetrahydro-5H-carbazole-3-carboxamide
- UNII-H82Q2D5WA7
- Frovatriptan (INN)
- H82Q2D5WA7
- (R)-5,6,7,8-Tetrahydro-6-(methylamino)carbazole-3-carboxamide
- (3R)-3-(methylamino)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide
- CHEMBL1279
- DTXSID0023080
- 1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-, (3R)-
- Allegro
- FROVATRIPTAN [INN]
- 1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-, (R)-
- SB 209509
- FROVATRIPTAN (MART.)
- FROVATRIPTAN [MART.]
- Auradol
- Rilamig
- R-Frovatriptan
- Frovatriptan [INN:BAN]
- frovatriptanum
- 3-methylamino-6-carboxamido-1,2,3,4-tetrahydrocarbazole
- SB-209509
- FROVATRIPTAN [MI]
- FROVATRIPTAN [HSDB]
- Allergo filmtabletten (TN)
- (R)-Frovatriptan;SB209509;SB-209509;SB 209509
- FROVATRIPTAN [VANDF]
- BIDD:PXR0142
- SCHEMBL34410
- FROVATRIPTAN [WHO-DD]
- DTXCID703080
- GTPL7191
- N02CC07
- CHEBI:134991
- HY-B1658
- BDBM50073689
- DB00998
- NCGC00408835-01
- DA-53409
- CS-0013614
- NS00007851
- D07997
- EN300-24114152
- Q410195
- BRD-K08255599-365-01-1
- (3R)-3-(methylamino)-2,3,4,9-tetrahydro-1H-carbazole-6-carboximidic acid
- (R)-6-Methylamino-6,7,8,9-tetrahydro-5H-carbazole-3-carboxylic acid amide
4.2 L/kg [males]
3 L/kg [females]
220 mL/min [male receiving IV dose of 0.8 mg]
130 mL/min [Female receiving IV dose of 0.8 mg]
M Chen, V Vijay, Q Shi, Z Liu, H Fang, W Tong. FDA-Approved Drug Labeling for the Study of Drug-Induced Liver Injury, Drug Discovery Today, 16(15-16):697-703, 2011. PMID:21624500 DOI:10.1016/j.drudis.2011.05.007
M Chen, A Suzuki, S Thakkar, K Yu, C Hu, W Tong. DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug Discov Today 2016, 21(4): 648-653. PMID:26948801 DOI:10.1016/j.drudis.2016.02.015
◉ Summary of Use during Lactation
There is no published experience with frovatriptan during breastfeeding. If frovatriptan is required by the mother of an older infant, it is not a reason to discontinue breastfeeding, but until more data become available, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. Painful, burning nipples and breast pain have been reported after doses of sumatriptan and other triptans. This has occasionally been accompanied by a decrease in milk production.
◉ Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk
A review of four European adverse reaction databases found 26 reported cases of, painful, burning nipples, painful breasts, breast engorgement and/or painful milk ejection in women who took a triptan while nursing. Pain was sometimes intense and occasionally led to decreased milk production. Pain generally subsided with time as the drug was eliminated. The authors proposed that triptans may cause vasoconstriction of the arteries in the breast, nipples, and the arteries surrounding the alveoli and milk ducts, causing a painful sensation and a painful milk ejection reflex.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=XPSQPHWEGNHMSK-SECBINFHSA-N
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/
- ChemIDplusFrovatriptan [INN:BAN]https://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0158747025ChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- DrugBankLICENSECreative Common's Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/legalcode)https://www.drugbank.ca/legal/terms_of_useFrovatriptanhttps://www.drugbank.ca/drugs/DB00998
- EPA DSSToxFrovatriptanhttps://comptox.epa.gov/dashboard/DTXSID0023080CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
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- Hazardous Substances Data Bank (HSDB)
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- ChEBI
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- Open TargetsLICENSEDatasets generated by the Open Targets Platform are freely available for download.https://platform-docs.opentargets.org/licenceFROVATRIPTANhttps://platform.opentargets.org/drug/CHEMBL1279
- Toxin and Toxin Target Database (T3DB)LICENSET3DB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (T3DB) and the original publication.http://www.t3db.ca/downloadsFrovatriptanhttp://www.t3db.ca/toxins/T3D2954
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- Drug Gene Interaction database (DGIdb)LICENSEThe data used in DGIdb is all open access and where possible made available as raw data dumps in the downloads section.http://www.dgidb.org/downloadsFROVATRIPTANhttps://www.dgidb.org/drugs/rxcui:228783
- IUPHAR/BPS Guide to PHARMACOLOGYLICENSEThe Guide to PHARMACOLOGY database is licensed under the Open Data Commons Open Database License (ODbL) https://opendatacommons.org/licenses/odbl/. Its contents are licensed under a Creative Commons Attribution-ShareAlike 4.0 International License (http://creativecommons.org/licenses/by-sa/4.0/)https://www.guidetopharmacology.org/about.jsp#licenseGuide to Pharmacology Target Classificationhttps://www.guidetopharmacology.org/targets.jsp
- Therapeutic Target Database (TTD)Frovatriptanhttps://idrblab.net/ttd/data/drug/details/D06FPQ
- Drug Induced Liver Injury Rank (DILIrank) DatasetLICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linking
- Drugs and Lactation Database (LactMed)
- Drugs@FDALICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linking
- EU Clinical Trials Register
- Japan Chemical Substance Dictionary (Nikkaji)
- KEGGLICENSEAcademic users may freely use the KEGG website. Non-academic use of KEGG generally requires a commercial licensehttps://www.kegg.jp/kegg/legal.htmlAnatomical Therapeutic Chemical (ATC) classificationhttp://www.genome.jp/kegg-bin/get_htext?br08303.kegTarget-based classification of drugshttp://www.genome.jp/kegg-bin/get_htext?br08310.keg
- Metabolomics Workbench
- NCI Thesaurus (NCIt)LICENSEUnless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.https://www.cancer.gov/policies/copyright-reuseNCI Thesaurushttps://ncit.nci.nih.gov
- NLM RxNorm TerminologyLICENSEThe RxNorm Terminology is created by the National Library of Medicine (NLM) and is in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from NLM. Credit to the U.S. National Library of Medicine as the source is appreciated but not required. The full RxNorm dataset requires a free license.https://www.nlm.nih.gov/research/umls/rxnorm/docs/termsofservice.htmlfrovatriptanhttps://rxnav.nlm.nih.gov/id/rxnorm/228783
- NORMAN Suspect List ExchangeLICENSEData: CC-BY 4.0; Code (hosted by ECI, LCSB): Artistic-2.0https://creativecommons.org/licenses/by/4.0/FrovatriptanNORMAN Suspect List Exchange Classificationhttps://www.norman-network.com/nds/SLE/
- WHO Anatomical Therapeutic Chemical (ATC) ClassificationLICENSEUse of all or parts of the material requires reference to the WHO Collaborating Centre for Drug Statistics Methodology. Copying and distribution for commercial purposes is not allowed. Changing or manipulating the material is not allowed.https://www.whocc.no/copyright_disclaimer/Frovatriptanhttps://www.whocc.no/atc_ddd_index/?code=N02CC07
- PharmGKBLICENSEPharmGKB data are subject to the Creative Commons Attribution-ShareALike 4.0 license (https://creativecommons.org/licenses/by-sa/4.0/).https://www.pharmgkb.org/page/policiesfrovatriptanhttps://www.pharmgkb.org/chemical/PA164754891
- PharosLICENSEData accessed from Pharos and TCRD is publicly available from the primary sources listed above. Please respect their individual licenses regarding proper use and redistribution.https://pharos.nih.gov/aboutfrovatriptanhttps://pharos.nih.gov/ligands/651G8HLUVTLD
- Thieme ChemistryLICENSEThe Thieme Chemistry contribution within PubChem is provided under a CC-BY-NC-ND 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc-nd/4.0/
- Wikidatafrovatriptanhttps://www.wikidata.org/wiki/Q410195
- Wikipedia3,4-Methylenedioxyamphetaminehttps://en.wikipedia.org/wiki/3,4-MethylenedioxyamphetamineFrovatriptanhttps://en.wikipedia.org/wiki/Frovatriptan
- Wiley
- PubChem
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.htmlfrovatriptanhttps://www.ncbi.nlm.nih.gov/mesh/67108128Serotonin Receptor Agonistshttps://www.ncbi.nlm.nih.gov/mesh/68017366
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 390018856https://pubchem.ncbi.nlm.nih.gov/substance/390018856
- NCBI