N,N-Dimethyl-p-toluidine
- C9H13N
- CH3C6H4N(CH3)2
- N,N-Dimethyl-p-toluidine
- 99-97-8
- N,N,4-TRIMETHYLANILINE
- Dimethyl-p-toluidine
- Benzenamine, N,N,4-trimethyl-
- Create:2005-03-26
- Modify:2024-12-27
C9H13N
CH3C6H4N(CH3)2
- dimethyl-4-toluidine
- dimethyl-p-toluidine
- dimethyl-para-toluidine
- N,N-dimethyl-p-toluidine
- N,N-Dimethyl-p-toluidine
- 99-97-8
- N,N,4-TRIMETHYLANILINE
- Dimethyl-p-toluidine
- Benzenamine, N,N,4-trimethyl-
- Dimethyl-4-toluidine
- N,N-Dimethyl-4-methylaniline
- N,N,4-Trimethylbenzenamine
- p-Methyl-N,N-dimethylaniline
- p-(Dimethylamino)toluene
- N,N-Dimethyl-p-tolylamine
- 4-Dimethylaminotoluene
- p-Toluidine, N,N-dimethyl-
- NSC 1785
- p,N,N-Trimethylaniline
- Dimetil-p-toluidina
- N,N-Dimethyl-4-toluidine
- dimethyltolylamine
- 1-(Dimethylamino)-4-methylbenzene
- 4,N,N-Trimethylaniline
- S8XC5939VU
- DTXSID0021832
- NSC-1785
- NL 65-100
- N,N-Dimethyl-para-toluidine
- aniline, N,N,4-trimethyl-
- DTXCID401832
- p-N,N-Trimethylaniline
- CAS-99-97-8
- Dimetil-p-toluidina [Italian]
- CCRIS 1001
- EINECS 202-805-4
- MFCD00008316
- UNII-S8XC5939VU
- Benzeneamine,N,N,4-trimethyl-
- HSDB 8202
- N,4-Trimethylaniline
- dimethyl-(p-tolyl)-amine
- EC 202-805-4
- Benzenamine,N,4-trimethyl-
- SCHEMBL28378
- MLS001050174
- 4-dimethylamino-1-methylbenzene
- 4,N,N-Trimethylaniline, 99%
- CHEMBL1462714
- N,N-Dimethyl-p-methylphenylamine
- NSC1785
- Tox21_201370
- Tox21_300062
- AC-368
- AKOS015915159
- N,N-DIMETHYL-P-TOLUIDINE [IARC]
- NCGC00091397-01
- NCGC00091397-02
- NCGC00091397-03
- NCGC00254201-01
- NCGC00258922-01
- SMR001216586
- D0807
- NS00002247
- E75885
- EN300-7266829
- 4,N,N-Trimethylaniline, purum, >=98.0% (GC)
- Q2051705
- W-100002
- Z1002998236
- platinum(2+); 4-(1H-pyrazol-4-ylmethyl)-1H-pyrazole; tetrachloride
134 99.99
91 19.20
119 13.50
118 12.10
65 10.10
135 99.99
134 96.60
136 10.20
119 9.40
91 8.40
134 999
91 192
119 135
118 121
65 101
- Intermediates
- Not Known or Reasonably Ascertainable
- Paint additives and coating additives not described by other categories
Cosmetics product ingredient: N,N-Dimethyl-p-toluidine (Dimethyltolylamine)
Reason for Listing:
- Known to cause cancer under Health and Safety Code section 25249.8 of the California Safe Drinking Water and Toxic Enforcement Act of 1986 (Prop 65).
- Group 2B carcinogen identified by the International Agency for Research on Cancer.
Potential Health Impacts: Carcinogenicity
Product count: 59
2019: 500,000 - <1,000,000 lb
2018: <1,000,000 lb
2017: <1,000,000 lb
2016: <1,000,000 lb
- Plastics Material and Resin Manufacturing
- Not Known or Reasonably Ascertainable
- Miscellaneous Manufacturing
H301+H311+H331 (19.2%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
H301 (99.6%): Toxic if swallowed [Danger Acute toxicity, oral]
H311 (97.3%): Toxic in contact with skin [Danger Acute toxicity, dermal]
H331 (94.9%): Toxic if inhaled [Danger Acute toxicity, inhalation]
H373 (99.6%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
H410 (13%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]
H412 (86.8%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]
P260, P261, P262, P264, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P316, P319, P321, P330, P361+P364, P391, P403+P233, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 546 reports by companies from 29 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Reported as not meeting GHS hazard criteria per 1 of 546 reports by companies. For more detailed information, please visit ECHA C&L website.
There are 28 notifications provided by 545 of 546 reports by companies with hazard statement code(s).
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Acute Tox. 3 (99.6%)
Acute Tox. 3 (97.3%)
Acute Tox. 3 (94.9%)
STOT RE 2 (99.6%)
Aquatic Chronic 1 (13%)
Aquatic Chronic 3 (86.8%)
Acute toxicity (ingestion) - category 3
Acute toxicity (dermal) - category 3
Acute toxicity (inhalation) - category 3
Carcinogenicity - category 2
Specific target organ toxicity (repeated exposure) - category 2
Skin sensitisation - category 1
Hazardous to the aquatic environment (chronic) - category 3
Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:
TOXIC and/or CORROSIVE; inhalation, ingestion or skin contact with material may cause severe injury or death. Methyl bromoacetate (UN2643) is an eye irritant/lachrymator (causes flow of tears). Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause environmental contamination. (ERG, 2024)
Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:
Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Corrosives in contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. (ERG, 2024)
Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:
Refer to the "General First Aid" section. Specific First Aid: For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required. Removal of solidified molten material from skin requires medical assistance. (ERG, 2024)
Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:
SMALL FIRE: Dry chemical, CO2 or water spray.
LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal.
FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)
Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:
ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024)
Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:
Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)
Hazard Traits - Carcinogenicity
Authoritative List - IARC Carcinogens - 2B; Prop 65
Report - regardless of intended function of ingredient in the product
Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect
IARC Carcinogen - Class 3: Chemicals are not classifiable by the International Agency for Research on Cancer.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=GYVGXEWAOAAJEU-UHFFFAOYSA-N
- Australian Industrial Chemicals Introduction Scheme (AICIS)Benzenamine, N,N,4-trimethyl-https://services.industrialchemicals.gov.au/search-assessments/Benzenamine, N,N,4-trimethyl-https://services.industrialchemicals.gov.au/search-inventory/
- CAMEO ChemicalsLICENSECAMEO Chemicals and all other CAMEO products are available at no charge to those organizations and individuals (recipients) responsible for the safe handling of chemicals. However, some of the chemical data itself is subject to the copyright restrictions of the companies or organizations that provided the data.https://cameochemicals.noaa.gov/help/reference/terms_and_conditions.htm?d_f=falseN,N-DIMETHYL-P-TOLUIDINEhttps://cameochemicals.noaa.gov/chemical/17431CAMEO Chemical Reactivity Classificationhttps://cameochemicals.noaa.gov/browse/react
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/Dimethyl-p-toluidinehttps://commonchemistry.cas.org/detail?cas_rn=99-97-8
- ChemIDplusDimethyl-4-toluidinehttps://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0000099978ChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- DTP/NCILICENSEUnless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.https://www.cancer.gov/policies/copyright-reuse
- EPA Chemical Data Reporting (CDR)LICENSEThe U.S. Government retains a nonexclusive, royalty-free license to publish or reproduce these documents, or allow others to do so, for U.S. Government purposes. These documents may be freely distributed and used for non-commercial, scientific and educational purposes.https://www.epa.gov/web-policies-and-procedures/epa-disclaimers#copyrightBenzenamine, N,N,4-trimethyl-https://www.epa.gov/chemical-data-reporting
- EPA Chemicals under the TSCABenzenamine, N,N,4-trimethyl-https://www.epa.gov/chemicals-under-tscaEPA TSCA Classificationhttps://www.epa.gov/tsca-inventory
- EPA DSSToxN,N,4-Trimethylanilinehttps://comptox.epa.gov/dashboard/DTXSID0021832CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
- European Chemicals Agency (ECHA)LICENSEUse of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.https://echa.europa.eu/web/guest/legal-noticeN,N-dimethyl-p-toluidinehttps://chem.echa.europa.eu/100.002.551N,N-dimethyl-p-toluidine (EC: 202-805-4)https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/70326
- FDA Global Substance Registration System (GSRS)LICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linkingDIMETHYLTOLYLAMINEhttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/S8XC5939VU
- Hazardous Substances Data Bank (HSDB)Dimethyl-4-toluidinehttps://pubchem.ncbi.nlm.nih.gov/source/hsdb/8202
- ILO-WHO International Chemical Safety Cards (ICSCs)N,N-DIMETHYL-p-TOLUIDINEhttps://www.ilo.org/dyn/icsc/showcard.display?p_version=2&p_card_id=0456
- New Zealand Environmental Protection Authority (EPA)LICENSEThis work is licensed under the Creative Commons Attribution-ShareAlike 4.0 International licence.https://www.epa.govt.nz/about-this-site/general-copyright-statement/
- California Safe Cosmetics Program (CSCP) Product DatabaseN,N-Dimethyl-p-toluidinehttps://www.cdph.ca.gov/Programs/CCDPHP/DEODC/OHB/CSCP/Pages/About-CSCP.aspxN,N-Dimethyl-p-toluidine (Dimethyltolylamine)https://cscpsearch.cdph.ca.gov/search/detailresult/1122
- California Office of Environmental Health Hazard Assessment (OEHHA)N,N-Dimethyl-p-toluidinehttps://oehha.ca.gov/proposition-65/chemicals/nn-dimethyl-p-toluidine
- Haz-Map, Information on Hazardous Chemicals and Occupational DiseasesLICENSECopyright (c) 2022 Haz-Map(R). All rights reserved. Unless otherwise indicated, all materials from Haz-Map are copyrighted by Haz-Map(R). No part of these materials, either text or image may be used for any purpose other than for personal use. Therefore, reproduction, modification, storage in a retrieval system or retransmission, in any form or by any means, electronic, mechanical or otherwise, for reasons other than personal use, is strictly prohibited without prior written permission.https://haz-map.com/AboutN,N-Dimethyl-p-toluidinehttps://haz-map.com/Agents/2197
- ChEMBLLICENSEAccess to the web interface of ChEMBL is made under the EBI's Terms of Use (http://www.ebi.ac.uk/Information/termsofuse.html). The ChEMBL data is made available on a Creative Commons Attribution-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-sa/3.0/).http://www.ebi.ac.uk/Information/termsofuse.html
- Comparative Toxicogenomics Database (CTD)LICENSEIt is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.http://ctdbase.org/about/legal.jspdimethyl-4-toluidinehttps://ctdbase.org/detail.go?type=chem&acc=C015835
- EPA Chemical and Products Database (CPDat)N,N,4-Trimethylanilinehttps://comptox.epa.gov/dashboard/DTXSID0021832#exposureEPA CPDat Classificationhttps://www.epa.gov/chemical-research/chemical-and-products-database-cpdat
- Hazardous Chemical Information System (HCIS), Safe Work AustraliaN,N-dimethyl-p-toluidinehttp://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1517
- NITE-CMCN,N-Dimethyl-p-toluidine - FY2012 (New/original classication)https://www.chem-info.nite.go.jp/chem/english/ghs/12-mhlw-0047e.htmlN,N-Dimethyl-p-toluidine - FY2022 (Revised classification)https://www.chem-info.nite.go.jp/chem/english/ghs/22-jniosh-2091e.htmlN,N-Dimethyl-p-toluidine - FY2016 (Revised classification)https://www.chem-info.nite.go.jp/chem/english/ghs/16-mhlw-0114e.html
- Regulation (EC) No 1272/2008 of the European Parliament and of the CouncilLICENSEThe copyright for the editorial content of this source, the summaries of EU legislation and the consolidated texts, which is owned by the EU, is licensed under the Creative Commons Attribution 4.0 International licence.https://eur-lex.europa.eu/content/legal-notice/legal-notice.htmlN,N-dimethyl-p-toluidinehttps://eur-lex.europa.eu/eli/reg/2008/1272/oj
- IUPAC Digitized pKa Datasetaniline, N,N,4-trimethyl-https://github.com/IUPAC/Dissociation-Constants
- MassBank EuropeN,N-DIMETHYL-PARA-TOLUIDINEhttps://massbank.eu/MassBank/Result.jsp?inchikey=GYVGXEWAOAAJEU-UHFFFAOYSA-N
- NMRShiftDB
- Human Metabolome Database (HMDB)LICENSEHMDB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (HMDB) and the original publication (see the HMDB citing page). We ask that users who download significant portions of the database cite the HMDB paper in any resulting publications.http://www.hmdb.ca/citingN,N-Dimethyl-p-toluidinehttp://www.hmdb.ca/metabolites/HMDB0255257
- International Agency for Research on Cancer (IARC)LICENSEMaterials made available by IARC/WHO enjoy copyright protection under the Berne Convention for the Protection of Literature and Artistic Works, under other international conventions, and under national laws on copyright and neighbouring rights. IARC exercises copyright over its Materials to make sure that they are used in accordance with the Agency's principles. All rights are reserved.https://publications.iarc.fr/Terms-Of-UseN,N-Dimethyl-p-toluidinehttps://monographs.iarc.who.int/list-of-classificationsIARC Classificationhttps://www.iarc.fr/
- Japan Chemical Substance Dictionary (Nikkaji)
- MassBank of North America (MoNA)LICENSEThe content of the MoNA database is licensed under CC BY 4.0.https://mona.fiehnlab.ucdavis.edu/documentation/license
- NIST Mass Spectrometry Data CenterLICENSEData covered by the Standard Reference Data Act of 1968 as amended.https://www.nist.gov/srd/public-lawBenzenamine, N,N,4-trimethyl-http://www.nist.gov/srd/nist1a.cfm
- SpectraBaseN,N,4-Trimethylanilinehttps://spectrabase.com/spectrum/2o7fAdueIUKN,N,4-Trimethylanilinehttps://spectrabase.com/spectrum/8KIqSu4crCqN,N-DIMETHYL-p-TOLUIDINEhttps://spectrabase.com/spectrum/4bUDNvmXMD2N,N-Dimethyl-P-toluidinehttps://spectrabase.com/spectrum/CzyWBQs0EHfN,N-dimethyl-p-toluidinehttps://spectrabase.com/spectrum/C71aMg9Bcd04,N,N-Trimethylanilinehttps://spectrabase.com/spectrum/pjXsEPm3cfN,N,4-TRIMETHYLANILINEhttps://spectrabase.com/spectrum/51bjndu65s7N,N,4-TRIMETHYLANILINEhttps://spectrabase.com/spectrum/1Qe5n6Fc7uIN,N-DIMETHYL-p-TOLUIDINEhttps://spectrabase.com/spectrum/Koo6TdXZ1Ot4-Dimethylamino-1-methylbenzenehttps://spectrabase.com/spectrum/DMOEKr8CptLP-TOLUIDINE, N,N-DIMETHYL-,https://spectrabase.com/spectrum/DuswDzBBE54,N,N-Trimethylanilinehttps://spectrabase.com/spectrum/LciGUj06vLPBenzenamine, N,N,4-trimethyl-https://spectrabase.com/spectrum/CbbAp0b1eUnBenzenamine, N,N,4-trimethyl-https://spectrabase.com/spectrum/CgLfyIl6hf54,N,N-Trimethylanilinehttps://spectrabase.com/spectrum/GKTccPDXAQq4,N,N-Trimethylanilinehttps://spectrabase.com/spectrum/1pfBoHJhf1N
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- Springer Nature
- SpringerMaterialsN,N-dimethyl-p-toluidinehttps://materials.springer.com/substanceprofile/docs/smsid_qijwzorwgwkuwkcs
- Thieme ChemistryLICENSEThe Thieme Chemistry contribution within PubChem is provided under a CC-BY-NC-ND 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc-nd/4.0/
- WikidataN,N,4-trimethylbenzenaminehttps://www.wikidata.org/wiki/Q2051705
- Wiley
- PubChem
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.htmldimethyl-4-toluidinehttps://www.ncbi.nlm.nih.gov/mesh/67015835
- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
- NORMAN Suspect List ExchangeLICENSEData: CC-BY 4.0; Code (hosted by ECI, LCSB): Artistic-2.0https://creativecommons.org/licenses/by/4.0/NORMAN Suspect List Exchange Classificationhttps://www.norman-network.com/nds/SLE/
- EPA Substance Registry ServicesEPA SRS List Classificationhttps://sor.epa.gov/sor_internet/registry/substreg/LandingPage.do
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 403383584https://pubchem.ncbi.nlm.nih.gov/substance/403383584