Coumatetralyl
- COUMATETRALYL
- 5836-29-3
- Racumin
- Endrocid
- Endrocide
- Create:2011-12-26
- Modify:2024-12-28
- coumateralyl
- coumatetralyl
- COUMATETRALYL
- 5836-29-3
- Racumin
- Endrocid
- Endrocide
- Rodentin
- Endox
- Raucumin 57
- Cumatetralyl
- Bayer 25 634
- BAY ene 11183 B
- 3-(d-Tetralyl)-4-hydroxycoumarin
- Caswell No. 496A
- Coumatetralyl [BSI:ISO]
- Coumatetralyl [ISO]
- ENE 11183 B
- Cumatetralyl [German, Dutch]
- BAY 25634
- Coumetralyl
- CCRIS 6923
- 4-Hydroxy-3-(1,2,3,4-tetrahydro-1-naphthyl)coumarin
- 3-(alpha-Tetral)-4-oxycoumarin
- HSDB 1725
- UNII-NWK4HW86A8
- EINECS 227-424-0
- NWK4HW86A8
- 3-(alpha-Tetralyl)-4-hydroxycoumarin
- Coumarin, 4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthyl)-
- EPA Pesticide Chemical Code 496100
- BRN 1323631
- DTXSID8041799
- 4-Hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-2H-1-benzopyran-2-one
- 4-Hydroxy-3-(1,2,3,4-tetrahydro-1-naphthyl)-cumarin
- COUMATETRALYL [HSDB]
- 3-(.alpha.-Tetralyl)-4-hydroxycoumarin
- 2H-1-Benzopyran-2-one, 4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-
- 4-Hydroxy-3-(1,2,3,4-tetrahydro-1-naftyl)-cumarine
- 4-Idrossi-3-(1,2,3,4-tetraidro-1-naftil)-cumarina
- 3-(1,2,3,4-Tetrahydro-1-naphtyl)-4-hydroxycoumarine
- DTXCID6021799
- 4-Hydroxy-3-(1,2,3,4-tetrahydro-1-naftyl)-cumarine [Dutch]
- CHEBI:80742
- 3-(1,2,3,4-Tetrahydro-1-naphthyl)-4-hydroxycumarin [German]
- 3-(1,2,3,4-Tetrahydro-1-naphtyl)-4-hydroxycoumarine [French]
- 4-Idrossi-3-(1,2,3,4-tetraidro-1-naftil)-cumarina [Italian]
- 4-Hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)-2H-chromen-2-one
- 3-(1-Tetralyl)-4-hydroxycoumarin
- 3-(1,2,3,4-Tetrahydro-1-naphthyl)-4-hydroxycumarin
- 3-(1,2,3,4-Tetrahydro-1-naphthyl)-4-hydroxycoumarin
- 3-(.alpha.-Tetralinyl)-4-hydroxycoumarin
- 3-(.ALPHA.-TETRAL)-4-OXYCOUMARIN
- 3-(1,2,3,4-Tetrahydro-1-naphthyl)-4-hydroxycoumarine
- coumateralyl
- CUMATETRALYL (GERMAN, DUTCH)
- Murisan A
- Racumin 57
- 3-(1,2,3,4-TETRAHYDRO-1-NAPHTYL)-4-HYDROXYCOUMARINE (FRENCH)
- 4-HYDROXY-3-(1,2,3,4-TETRAHYDRO-1-NAFTYL)-CUMARINE (DUTCH)
- 4-IDROSSI-3-(1,2,3,4-TETRAIDRO-1-NAFTIL)-CUMARINA (ITALIAN)
- 3(alphaTetral)4oxycoumarin
- 3(dTetralyl)4hydroxycoumarin
- SCHEMBL137261
- SCHEMBL5933927
- 3(alphaTetralyl)4hydroxycoumarin
- CHEMBL3184636
- Tox21_301252
- AKOS015903266
- 3-(alpha-Tetralinyl)-4-hydroxycoumarin
- 4-Hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-2H-1-benzopyran-2-one (8CI)
- 4-Hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-2H-1-benzopyran-2-one (8CI)(9CI)
- USEPA/OPP Pesticide Code: 496100
- NCGC00255682-01
- AC-12689
- CAS-5836-29-3
- 4Idrossi3(1,2,3,4tetraidro1naftil)cumarina
- NS00047085
- 4Hydroxy3(1,2,3,4tetrahydro1naftyl)cumarine
- 3(1,2,3,4Tetrahydro1naphthyl)4hydroxycumarin
- 3(1,2,3,4Tetrahydro1naphtyl)4hydroxycoumarine
- 4Hydroxy3(1,2,3,4tetrahydro1naphthyl)coumarin
- 4Hydroxy3(1,2,3,4tetrahydro1naphthyl)cumarin
- Coumatetralyl, PESTANAL(R), analytical standard
- Coumarin, 4hydroxy3(1,2,3,4tetrahydro1naphthyl)
- Q415772
- 2H1Benzopyran2one, 4hydroxy3(1,2,3,4tetrahydro1naphthalenyl)
- 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)chromen-2-one
- 4Hydroxy3(1,2,3,4tetrahydro1naphthalenyl)2H1benzopyran2one (8CI)
- 4-Hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-2H-chromen-2-one #
- 4Hydroxy3(1,2,3,4tetrahydro1naphthalenyl)2H1benzopyran2one (8CI)(9CI)
- 2H-1-BENZOPYRAN-2-ONE, 4-HYDROXY-3-(1,2,3,4-TETRAHYDRO-1- NAPHTHALENYL)-
- 2H-1-Benzopyran-2-one, 4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-(9CI)
- 4-HYDROXY-3-(1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL)-2H-1- BENZOPYRAN-2-ONE
141.071 100
143.0502 30.75
106.0424 28.68
93.0346 22.63
135.0452 22.15
141.071 100
291.1027 72.88
247.1128 41.46
106.0424 32.97
135.0452 22.93
293.1173 999
175.039 267
91.0543 58
131.0856 49
163.0389 39
Cosmetics product ingredient: Coumatetralyl (ISO) (4- hydroxy-3-(1,2,3,4-tetrahydro-1-naphthyl) coumarin)
Reason for Listing: Classified by the European Union as a reproductive toxicant Category 1B in Annex VI to Regulation (EC) 1272/2008
Potential Health Impacts: Reproductive Toxicity
Product count: 1
H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]
H310 (97.7%): Fatal in contact with skin [Danger Acute toxicity, dermal]
H372 (100%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
H412 (97.7%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]
P260, P262, P264, P270, P273, P280, P301+P316, P302+P352, P316, P319, P321, P330, P361+P364, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 43 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Acute Tox. 2 (100%)
Acute Tox. 2 (97.7%)
STOT RE 1 (100%)
Aquatic Chronic 3 (97.7%)
Reproductive toxicity - category 1B
Acute toxicity - category 2
Acute toxicity - category 2
Acute toxicity - category 3
Specific target organ toxicity (repeated exposure) - category 1
Hazardous to the aquatic environment (chronic) - category 1
Signs and Symptoms of Coumatetralyl Exposure: Coumatetralyl is an anticoagulant. Hemorrhage is the most common sign and may be manifested by hemorrhagic skin rashes and lip, nose, and upper airway bleeding. Upper airway pain, difficulty in speaking and swallowing, and dyspnea (shortness of breath) may occur. Vomiting, abdominal pain, and bloody stools are common. Back pain may be noted.
Emergency Life-Support Procedures: Acute exposure to coumatetralyl exposure may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to coumatetralyl.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. RUSH to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to coumatetralyl.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas THOROUGHLY with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
7. RUSH to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of coumatetralyl is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step
4. Ipecac should not be administered to children under 6 months of age.Warning: Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step
4.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3- 1/2 oz) is recommended for adults.
6. RUSH to a health care facility. (EPA, 1998)
(Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Stay upwind; keep out of low areas. Wear positive pressure breathing apparatus and special protective clothing. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material.
(Non-Specific -- Coumarin Derivative Pesticide, Solid, n.o.s.) Small fires: dry chemical, carbon dioxide, water spray or foam. Large fires: water spray, fog or foam. (EPA, 1998)
Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
Alcohols and Polyols
Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters
Hazard Traits - Reproductive Toxicity
Authoritative List - EC Annex VI CMRs - Cat. 1B
Report - if used as a fragrance or flavor ingredient
IMAP assessments - 2H-1-Benzopyran-2-one, 4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-: Environment tier I assessment
IMAP assessments - 2H-1-Benzopyran-2-one, 4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-: Human health tier I assessment
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=ULSLJYXHZDTLQK-UHFFFAOYSA-N
- Australian Industrial Chemicals Introduction Scheme (AICIS)2H-1-Benzopyran-2-one, 4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-https://services.industrialchemicals.gov.au/search-assessments/
- CAMEO ChemicalsLICENSECAMEO Chemicals and all other CAMEO products are available at no charge to those organizations and individuals (recipients) responsible for the safe handling of chemicals. However, some of the chemical data itself is subject to the copyright restrictions of the companies or organizations that provided the data.https://cameochemicals.noaa.gov/help/reference/terms_and_conditions.htm?d_f=falseCOUMATETRALYLhttps://cameochemicals.noaa.gov/chemical/4928CAMEO Chemical Reactivity Classificationhttps://cameochemicals.noaa.gov/browse/react
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/
- ChemIDplusCoumatetralyl [BSI:ISO]https://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0005836293ChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- EPA DSSToxCoumatetralylhttps://comptox.epa.gov/dashboard/DTXSID8041799CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
- European Chemicals Agency (ECHA)LICENSEUse of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.https://echa.europa.eu/web/guest/legal-noticeCoumatetralyl (EC: 227-424-0)https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/124704
- FDA Global Substance Registration System (GSRS)LICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linking
- Hazardous Substances Data Bank (HSDB)COUMATETRALYLhttps://pubchem.ncbi.nlm.nih.gov/source/hsdb/1725
- New Zealand Environmental Protection Authority (EPA)LICENSEThis work is licensed under the Creative Commons Attribution-ShareAlike 4.0 International licence.https://www.epa.govt.nz/about-this-site/general-copyright-statement/
- NJDOH RTK Hazardous Substance List
- California Safe Cosmetics Program (CSCP) Product DatabaseCoumatetralyl (ISO) (4- hydroxy-3-(1,2,3,4-tetrahydro-1-naphthyl) coumarin)https://cscpsearch.cdph.ca.gov/search/detailresult/1909Coumatetralyl (ISO)https://www.cdph.ca.gov/Programs/CCDPHP/DEODC/OHB/CSCP/Pages/About-CSCP.aspx
- EU Pesticides Database
- Haz-Map, Information on Hazardous Chemicals and Occupational DiseasesLICENSECopyright (c) 2022 Haz-Map(R). All rights reserved. Unless otherwise indicated, all materials from Haz-Map are copyrighted by Haz-Map(R). No part of these materials, either text or image may be used for any purpose other than for personal use. Therefore, reproduction, modification, storage in a retrieval system or retransmission, in any form or by any means, electronic, mechanical or otherwise, for reasons other than personal use, is strictly prohibited without prior written permission.https://haz-map.com/AboutCoumatetralylhttps://haz-map.com/Agents/4528
- ChEBI
- ChEMBLLICENSEAccess to the web interface of ChEMBL is made under the EBI's Terms of Use (http://www.ebi.ac.uk/Information/termsofuse.html). The ChEMBL data is made available on a Creative Commons Attribution-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-sa/3.0/).http://www.ebi.ac.uk/Information/termsofuse.html
- Comparative Toxicogenomics Database (CTD)LICENSEIt is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.http://ctdbase.org/about/legal.jspcoumatetralylhttps://ctdbase.org/detail.go?type=chem&acc=C004699
- Hazardous Chemical Information System (HCIS), Safe Work Australia
- Regulation (EC) No 1272/2008 of the European Parliament and of the CouncilLICENSEThe copyright for the editorial content of this source, the summaries of EU legislation and the consolidated texts, which is owned by the EU, is licensed under the Creative Commons Attribution 4.0 International licence.https://eur-lex.europa.eu/content/legal-notice/legal-notice.htmlcoumatetralyl (ISO); 4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthyl)coumarinhttps://eur-lex.europa.eu/eli/reg/2008/1272/oj
- Human Metabolome Database (HMDB)LICENSEHMDB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (HMDB) and the original publication (see the HMDB citing page). We ask that users who download significant portions of the database cite the HMDB paper in any resulting publications.http://www.hmdb.ca/citingCoumatetralylhttp://www.hmdb.ca/metabolites/HMDB0250496HMDB0250496_msms_2235992https://hmdb.ca/metabolites/HMDB0250496#spectra
- Japan Chemical Substance Dictionary (Nikkaji)
- KEGGLICENSEAcademic users may freely use the KEGG website. Non-academic use of KEGG generally requires a commercial licensehttps://www.kegg.jp/kegg/legal.html
- MassBank Europe
- MassBank of North America (MoNA)LICENSEThe content of the MoNA database is licensed under CC BY 4.0.https://mona.fiehnlab.ucdavis.edu/documentation/license
- NIST Mass Spectrometry Data CenterLICENSEData covered by the Standard Reference Data Act of 1968 as amended.https://www.nist.gov/srd/public-law2H-1-Benzopyran-2-one, 4-hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-http://www.nist.gov/srd/nist1a.cfm
- SpectraBaseCoumatetralylhttps://spectrabase.com/spectrum/3DY6dr5g2KCoumatetralylhttps://spectrabase.com/spectrum/GXjQSEgIc8eCoumatetraylhttps://spectrabase.com/spectrum/E4XbB3VLCwz
- Springer Nature
- Thieme ChemistryLICENSEThe Thieme Chemistry contribution within PubChem is provided under a CC-BY-NC-ND 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc-nd/4.0/
- Wikidatacoumatetralylhttps://www.wikidata.org/wiki/Q415772
- WikipediaPropylaminehttps://en.wikipedia.org/wiki/PropylamineCoumatetralylhttps://en.wikipedia.org/wiki/Coumatetralyl
- PubChem
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.htmlcoumatetralylhttps://www.ncbi.nlm.nih.gov/mesh/67004699
- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
- NORMAN Suspect List ExchangeLICENSEData: CC-BY 4.0; Code (hosted by ECI, LCSB): Artistic-2.0https://creativecommons.org/licenses/by/4.0/NORMAN Suspect List Exchange Classificationhttps://www.norman-network.com/nds/SLE/
- EPA Substance Registry ServicesEPA SRS List Classificationhttps://sor.epa.gov/sor_internet/registry/substreg/LandingPage.do
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 403434961https://pubchem.ncbi.nlm.nih.gov/substance/403434961