Goserelin
- goserelin
- 65807-02-5
- Zoladex
- Decapeptide I
- Goserelinum
- Create:2005-12-16
- Modify:2025-01-10
- Acetate, Goserelin
- Goserelin
- Goserelin Acetate
- ICI 118630
- ICI-118630
- ICI118630
- Zoladex
- goserelin
- 65807-02-5
- Zoladex
- Decapeptide I
- Goserelinum
- Goserelina
- Gosereline
- ICI 118630
- ICI-118630
- UNII-0F65R8P09N
- Goserelinum [Latin]
- ICI 118,630
- HSDB 7606
- 0F65R8P09N
- D-Ser(t-Bu)(sup 6)aza-gly(sup 10)-GNRH
- DTXSID7048297
- Goserelinum (Latin)
- GOSERELIN (MART.)
- GOSERELIN [MART.]
- 1-(5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-O-tert-butyl-D-seryl-L-leucyl-L-arginyl-L-prolyl)semicarbazide
- 1233494-97-7
- GOSERELIN (EP MONOGRAPH)
- GOSERELIN [EP MONOGRAPH]
- (2S)-1-[(2S)-2-[(2S)-2-[(2R)-3-(TERT-BUTOXY)-2-[(2S)-2-[(2S)-3-HYDROXY-2-[(2S)-2-[(2S)-3-(1H-IMIDAZOL-4-YL)-2-{[(2S)-5-OXOPYRROLIDIN-2-YL]FORMAMIDO}PROPANAMIDO]-3-(1H-INDOL-3-YL)PROPANAMIDO]PROPANAMIDO]-3-(4-HYDROXYPHENYL)PROPANAMIDO]PROPANAMIDO]-4-METHYLPENTANAMIDO]-5-CARBAMIMIDAMIDOPENTANOYL]-N-(CARBAMOYLAMINO)PYRROLIDINE-2-CARBOXAMIDE
- (S)-N-((6S,9S,12R,15S,18S,21S,24S)-21-((1H-indol-3-yl)methyl)-1-amino-12-(tert-butoxymethyl)-6-((S)-2-(2-carbamoylhydrazine-1-carbonyl)pyrrolidine-1-carbonyl)-15-(4-hydroxybenzyl)-18-(hydroxymethyl)-25-(1H-imidazol-4-yl)-1-imino-9-isobutyl-8,11,14,17,20,23-hexaoxo-2,7,10,13,16,19,22-heptaazapentacosan-24-yl)-5-oxopyrrolidine-2-carboxamide
- Gosereline [French]
- Goserelina [Spanish]
- MFCD01747329
- Goserelin [USAN:INN:BAN]
- goserelin-acetate
- MFCD00867894
- HS-2015
- ZD-9393
- GOSERELIN [INN]
- GOSERELIN [MI]
- Goserelin (USAN/INN)
- GOSERELIN [HSDB]
- GOSERELIN [USAN]
- GOSERELIN [WHO-DD]
- SCHEMBL8643
- CHEBI:5523
- GTPL3879
- CHEMBL1201247
- DTXCID2028272
- SCHEMBL19712239
- SCHEMBL20459194
- L02AE03
- HMS2089D16
- AKOS015994653
- AKOS030213245
- DB00014
- NCGC00390804-01
- HY-13673
- [D-Ser(tBu)6,Azagly10]-LHRH acetate salt
- NS00120430
- (D-Ser(tBu)6,Azagly10)-LHRH (free base)
- D04405
- AB01275466-01
- EN300-7480905
- Q1992653
- BRD-K99504665-001-01-2
- 6-(O-(1,1-Dimethylethyl)-D-serine)-10-deglycinamide Luteinizing Hormone-Releasing Factor (Pig) 2-(aminocarbonyl)hydrazide
1269.65601 100
1226.64648 1.10
1267.64819 100
1224.61084 1.39
1224.62805 100
1194.61816 73.77
670.27441 72.44
449.26291 70.62
1267.63354 29.74
1269.65601 100
1226.64648 1.10
1252.61658 0.33
1252.64148 0.30
1265.71362 0.25
Use (kg) in USA (2002): 1
Consumption (g per capita) in the USA (2002): 3.13e-06
Calculated removal (%): 1.9
H317 (94.4%): May cause an allergic skin reaction [Warning Sensitization, Skin]
H332 (94.4%): Harmful if inhaled [Warning Acute toxicity, inhalation]
H334 (94.4%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]
P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P317, P321, P333+P317, P342+P316, P362+P364, P403, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 18 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Skin Sens. 1 (94.4%)
Acute Tox. 4 (94.4%)
Resp. Sens. 1 (94.4%)
Goserelin has been associated with mild serum enzyme elevations during therapy in 3% to 5% of patients, but values above 3 times the upper limit of normal are rare, being reported in less than 1% of recipients. The serum enzyme elevations during goserelin therapy have generally been transient and asymptomatic, resolving even with drug continuation and rarely requiring dose modification or discontinuation. Despite use for several decades, goserelin has been linked to only a single, and not entirely convincing, case of clinically apparent liver injury. Routine monitoring of patients for liver test abnormalities is not recommended.
Likelihood score: D (possible, rare cause of clinically apparent liver injury).
M Chen, V Vijay, Q Shi, Z Liu, H Fang, W Tong. FDA-Approved Drug Labeling for the Study of Drug-Induced Liver Injury, Drug Discovery Today, 16(15-16):697-703, 2011. PMID:21624500 DOI:10.1016/j.drudis.2011.05.007
M Chen, A Suzuki, S Thakkar, K Yu, C Hu, W Tong. DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug Discov Today 2016, 21(4): 648-653. PMID:26948801 DOI:10.1016/j.drudis.2016.02.015
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=BLCLNMBMMGCOAS-URPVMXJPSA-N
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