Cancidas
- Caspofungin
- Cancidas
- MK-991
- Cancidas (TN)
- 162808-62-0
- Create:2005-07-20
- Modify:2025-01-18
- Cancidas
- caspofungin
- caspofungin acetate
- Caspofungin MSD
- L 743,872
- L 743872
- L-743,872
- L-743872
- L743,872
- L743872
- MK 0991
- MK-0991
- MK0991
- Caspofungin
- Cancidas
- MK-991
- Cancidas (TN)
- 162808-62-0
- CHEBI:474180
- Caspofungin (INN)
- N-[(3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-aminoethylamino)-3-[(1R)-3-amino-1-hydroxypropyl]-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,25-trihydroxy-15-[(1R)-1-hydroxyethyl]-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexazatricyclo[22.3.0.09,13]heptacosan-18-yl]-10,12-dimethyltetradecanamide
- L-743872
- L-743,872
- DTXSID30873204
- MK-0991
- CHEMBL499808
- SCHEMBL6726364
- JYIKNQVWKBUSNH-OGZDCFRISA-N
- N-[(2-aminoethylamino)-[(1R)-3-amino-1-hydroxy-propyl]-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-trihydroxy-[(1R)-1-hydroxyethyl]-hexaoxo-[?]yl]-10,12-dimethyl-tetradecanamide
- BDBM50478215
- NSC754342
- NSC-754342
- D07626
- Q420875
- Pneumocandin B0, 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-(threo-3-hydroxy-L-ornithine)-
- Pneumocandin B0, 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]- (9CI)
Use (kg) in USA (2002): 5
Consumption (g per capita) in the USA (2002): 1.78e-05
Calculated removal (%): 1.9
M Chen, V Vijay, Q Shi, Z Liu, H Fang, W Tong. FDA-Approved Drug Labeling for the Study of Drug-Induced Liver Injury, Drug Discovery Today, 16(15-16):697-703, 2011. PMID:21624500 DOI:10.1016/j.drudis.2011.05.007
M Chen, A Suzuki, S Thakkar, K Yu, C Hu, W Tong. DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug Discov Today 2016, 21(4): 648-653. PMID:26948801 DOI:10.1016/j.drudis.2016.02.015
◉ Summary of Use during Lactation
No information is available on the use of caspofungin during breastfeeding. Because caspofungin is 97% bound to plasma proteins and has poor oral bioavailability, it is unlikely to reach the milk and be absorbed by the infant. Caspofungin can safely be given intravenously to infants of aged 3 months or older. Any amount absorbed from milk is likely to be far less than an infant dose. If caspofungin is required by the mother, it is not a reason to discontinue breastfeeding.
◉ Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=JYIKNQVWKBUSNH-OGZDCFRISA-N
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- Drug Induced Liver Injury Rank (DILIrank) DatasetLICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linking
- DrugBankLICENSECreative Common's Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/legalcode)https://www.drugbank.ca/legal/terms_of_useCaspofunginhttps://www.drugbank.ca/drugs/DB00520
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- Hazardous Substances Data Bank (HSDB)
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- Therapeutic Target Database (TTD)
- Drugs and Lactation Database (LactMed)
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- EU Clinical Trials Register
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- Metabolomics Workbench
- Natural Product Activity and Species Source (NPASS)
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- Wikidatacaspofunginhttps://www.wikidata.org/wiki/Q420875
- WikipediaCaspofunginhttps://en.wikipedia.org/wiki/Caspofungin
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- PubChem
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- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 389459982https://pubchem.ncbi.nlm.nih.gov/substance/389459982
- NCBI