2-Chloro-1-propanol
- 2-Chloropropan-1-ol
- 2-CHLORO-1-PROPANOL
- 78-89-7
- 2-Chloropropanol
- 1-Propanol, 2-chloro-
- Create:2005-03-26
- Modify:2025-01-25
- 2-chloro-1-propanol
- propylene chlorohydrin
- propylenechlorohydrin
- 2-Chloropropan-1-ol
- 2-CHLORO-1-PROPANOL
- 78-89-7
- 2-Chloropropanol
- 1-Propanol, 2-chloro-
- Propylene chlorohydrin
- 2-Chloropropyl alcohol
- Propylenechlorohydrin
- 1-Hydroxy-2-chloropropane
- beta-Chloropropyl alcohol
- .beta.-Chloropropyl alcohol
- 2-chloro-propan-1-ol
- (R)-(-)-2-Chloro-1-propanol
- NSC-122672
- W3398732C7
- CCRIS 875
- HSDB 5223
- EINECS 201-154-3
- NSC 122672
- Propylenchlorhydrin
- 1-Propanol, 2-chloro-, (S)-
- UNII-W3398732C7
- (r)-2-chloro-1-propanol
- WLN: Q1YG1
- DTXSID5052541
- (S)-(-)-2-Chloro-1-propanol
- PROPYLENE CHLOROHYDRIN [MI]
- .BETA.-PROPYLENE CHLOROHYDRIN
- NSC122672
- AKOS006228269
- SB44668
- SB44669
- UN 2611
- 1-HYDROXY-2-CHLOROPROPANE [HSDB]
- SY240135
- NS00021358
- Propylene chlorohydrin [UN2611] [Poison]
- EN300-91182
- G28183
- J-640389
- W-109278
- Q15461615
- Cytoplasm
- Extracellular
H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P321, P330, P337+P317, P362+P364, P370+P378, P403+P235, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Flam. Liq. 3 (100%)
Acute Tox. 4 (100%)
Acute Tox. 4 (100%)
Eye Irrit. 2 (100%)
Acute Tox. 4 (100%)
Flammable liquids - Category 3
Acute toxicity (Oral) - Category 3
Acute toxicity (Dermal) - Category 3
Skin corrosion/irritation - Category 2
Serious eye damage/eye irritation - Category 2
Germ cell mutagenicity - Category 2
Specific target organ toxicity - Single exposure - Category 3 (Respiratory tract irritation, Narcotic effects)
Specific target organ toxicity - Repeated exposure - Category 1 (blood system, liver), Category 2 (kidney, pancreas)
SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin, eyes, mucous membranes, or lungs. It is a severe eye irritant. It may cause destruction of red blood cells (hemolysis).
ACUTE/CHRONIC HAZARDS: This chemical is a poison by ingestion. It is moderately toxic by inhalation and skin contact. It is a skin irritant and a severe eye irritant. When heated to decomposition it emits toxic fumes of chlorine. (NTP, 1992)
Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]:
TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Methyl chloroacetate (UN2295) is an eye irritant/lachrymator (causes flow of tears). Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or asphyxiation, especially when in closed or confined areas. Runoff from fire control or dilution water may cause environmental contamination. (ERG, 2024)
· TOXIC; may be fatal if inhaled, ingested or absorbed through skin.
· Inhalation or contact with some of these materials will irritate or burn skin and eyes.
· Methyl chloroacetate (UN2295) is an eye irritant/lachrymator (causes flow of tears).
· Fire will produce irritating, corrosive and/or toxic gases.
· Vapors may cause dizziness or asphyxiation, especially when in closed or confined areas.
· Runoff from fire control or dilution water may cause environmental contamination.
Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]:
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. CAUTION: Methanol (UN1230) will burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.) Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.). Vapor explosion and poison hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids will float on water. (ERG, 2024)
· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.
CAUTION: Methanol (UN1230) will burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.)
· Vapors may form explosive mixtures with air.
· Vapors may travel to source of ignition and flash back.
· Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).
· Vapor explosion and poison hazard indoors, outdoors or in sewers.
· Those substances designated with a (P) may polymerize explosively when heated or involved in a fire.
· Runoff to sewer may create fire or explosion hazard.
· Containers may explode when heated.
· Many liquids will float on water.
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]:
Refer to the "General First Aid" section. Specific First Aid: Wash skin with soap and water. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. (ERG, 2024)
General First Aid:
· Call 911 or emergency medical service.
· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.
· Move victim to fresh air if it can be done safely.
· Administer oxygen if breathing is difficult.
· If victim is not breathing:
-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingestedor inhaled the substance.
-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).
-- If no pulse detected or no respiratory medical device available, provide continuouscompressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.
· Remove and isolate contaminated clothing and shoes.
· For minor skin contact, avoid spreading material on unaffected skin.
· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.
· For severe burns, immediate medical attention is required.
· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.
· Keep victim calm and warm.
· Keep victim under observation.
· For further assistance, contact your local Poison Control Center.
· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.
Specific First Aid:
· Wash skin with soap and water.
· In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin.
In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.
Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]:
CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient. CAUTION: Methanol (UN1230) will burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.).
SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam.
LARGE FIRE: Water spray, fog or alcohol-resistant foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Avoid aiming straight or solid streams directly onto the product.
FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)
· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.
· Keep unauthorized personnel away.
· Stay upwind, uphill and/or upstream.
· Ventilate closed spaces before entering, but only if properly trained and equipped.
· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.
· All equipment used when handling the product must be grounded.
· Do not touch or walk through spilled material.
· Stop leak if you can do it without risk.
· Prevent entry into waterways, sewers, basements or confined areas.
· A vapor-suppressing foam may be used to reduce vapors.
Small Spill
· Absorb with earth, sand or other non-combustible material and transfer to containers for later disposal.
· Use clean, non-sparking tools to collect absorbed material.
Large Spill
· Dike far ahead of liquid spill for later disposal.
· Water spray may reduce vapor, but may not prevent ignition in closed spaces.
Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
Immediate precautionary measure
· Isolate spill or leak area for at least 50 meters (150 feet) in all directions.
Spill
· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.
· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.
Fire
· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
SMALL SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS: You should protect this material from exposure to light, and store it in a refrigerator. (NTP, 1992)
Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]:
ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors.
SMALL SPILL: Absorb with earth, sand or other non-combustible material and transfer to containers for later disposal. Use clean, non-sparking tools to collect absorbed material.
LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2024)
· Wear positive pressure self-contained breathing apparatus (SCBA).
· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.
· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.
CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.
CAUTION: Methanol (UN1230) will burn with an invisible flame. Use an alternate method of detection (thermal camera, broom handle, etc.)
Small Fire
· Dry chemical, CO2, water spray or alcohol-resistant foam.
Large Fire
· Water spray, fog or alcohol-resistant foam.
· If it can be done safely, move undamaged containers away from the area around the fire.
· Dike runoff from fire control for later disposal.
· Avoid aiming straight or solid streams directly onto the product.
Fire Involving Tanks, Rail Tank Cars or Highway Tanks
· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.
· Cool containers with flooding quantities of water until well after fire is out.
· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.
· ALWAYS stay away from tanks in direct contact with flames.
· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.
RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. Splash proof safety goggles should be worn while handling this chemical. Alternatively, a full face respirator, equipped as above, may be used to provide simultaneous eye and respiratory protection.
RECOMMENDED GLOVE MATERIALS: If this chemical makes direct contact with your gloves, or if a tear, puncture or hole develops, replace them at once.
Glove Type Model Number Thickness Bkthru Time
Nitrile Edmont 37-175 0.64 mm 190 min
PVA Edmont 25-545 0.89 mm 480 min
PVC Edmont 34-100 0.20 mm 5 min
Viton North F-101 0.36 mm 480 min
Butyl rubber North B-144 0.43 mm 480 min (NTP, 1992)
Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]:
Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE. Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. (ERG, 2024)
Alcohols and Polyols
Halogenated Organic Compounds
Neurotoxin - Acute solvent syndrome
ACGIH Carcinogen - Not Classifiable.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=VZIQXGLTRZLBEX-UHFFFAOYSA-N
- Australian Industrial Chemicals Introduction Scheme (AICIS)1-Propanol, 2-chloro-https://services.industrialchemicals.gov.au/search-assessments/1-Propanol, 2-chloro-https://services.industrialchemicals.gov.au/search-inventory/
- CAMEO ChemicalsLICENSECAMEO Chemicals and all other CAMEO products are available at no charge to those organizations and individuals (recipients) responsible for the safe handling of chemicals. However, some of the chemical data itself is subject to the copyright restrictions of the companies or organizations that provided the data.https://cameochemicals.noaa.gov/help/reference/terms_and_conditions.htm?d_f=false2-CHLORO-1-PROPANOLhttps://cameochemicals.noaa.gov/chemical/2919PROPYLENE CHLOROHYDRINhttps://cameochemicals.noaa.gov/chemical/2917CAMEO Chemical Reactivity Classificationhttps://cameochemicals.noaa.gov/browse/react
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/Propylene chlorohydrinhttps://commonchemistry.cas.org/detail?cas_rn=78-89-7
- ChemIDplus2-Chloro-1-propanolhttps://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=00000788971-Propanol, 2-chloro-, (S)-https://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0019210210ChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- DTP/NCILICENSEUnless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.https://www.cancer.gov/policies/copyright-reuse
- EPA Chemicals under the TSCA1-Propanol, 2-chloro-https://www.epa.gov/chemicals-under-tscaEPA TSCA Classificationhttps://www.epa.gov/tsca-inventory
- EPA DSSTox2-Chloro-1-propanolhttps://comptox.epa.gov/dashboard/DTXSID5052541CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
- European Chemicals Agency (ECHA)LICENSEUse of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.https://echa.europa.eu/web/guest/legal-notice2-chloropropan-1-olhttps://echa.europa.eu/substance-information/-/substanceinfo/100.001.0502-chloropropan-1-ol (EC: 201-154-3)https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/77535
- FDA Global Substance Registration System (GSRS)LICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linkingPROPYLENE CHLOROHYDRINhttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/W3398732C7
- Hazardous Substances Data Bank (HSDB)2-CHLORO-1-PROPANOLhttps://pubchem.ncbi.nlm.nih.gov/source/hsdb/5223
- Human Metabolome Database (HMDB)LICENSEHMDB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (HMDB) and the original publication (see the HMDB citing page). We ask that users who download significant portions of the database cite the HMDB paper in any resulting publications.http://www.hmdb.ca/citing2-Chloro-1-propanolhttp://www.hmdb.ca/metabolites/HMDB0031335
- New Zealand Environmental Protection Authority (EPA)LICENSEThis work is licensed under the Creative Commons Attribution-ShareAlike 4.0 International licence.https://www.epa.govt.nz/about-this-site/general-copyright-statement/
- Emergency Response Guidebook (ERG)Propylene chlorohydrinhttps://pubchem.ncbi.nlm.nih.gov/erg/
- Haz-Map, Information on Hazardous Chemicals and Occupational DiseasesLICENSECopyright (c) 2022 Haz-Map(R). All rights reserved. Unless otherwise indicated, all materials from Haz-Map are copyrighted by Haz-Map(R). No part of these materials, either text or image may be used for any purpose other than for personal use. Therefore, reproduction, modification, storage in a retrieval system or retransmission, in any form or by any means, electronic, mechanical or otherwise, for reasons other than personal use, is strictly prohibited without prior written permission.https://haz-map.com/About2-Chloro-1-propanolhttps://haz-map.com/Agents/3084
- NCI Thesaurus (NCIt)LICENSEUnless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.https://www.cancer.gov/policies/copyright-reuseNCI Thesaurushttps://ncit.nci.nih.gov
- NITE-CMC2-Chloro-1-propanol - FY2015 (New/original classication)https://www.chem-info.nite.go.jp/chem/english/ghs/15-mhlw-0005e.html
- FDA Substances Added to FoodLICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linking
- Japan Chemical Substance Dictionary (Nikkaji)
- Metabolomics Workbench2-Chloro-1-propanolhttps://www.metabolomicsworkbench.org/data/StructureData.php?RegNo=44830
- NIST Mass Spectrometry Data CenterLICENSEData covered by the Standard Reference Data Act of 1968 as amended.https://www.nist.gov/srd/public-law1-Propanol, 2-chloro-http://www.nist.gov/srd/nist1a.cfm
- SpectraBase1-PROPANOL, 2-CHLORO-https://spectrabase.com/spectrum/4Dj9aXLqvOg1-PROPANOL, 2-CHLORO-https://spectrabase.com/spectrum/CziWrrdUooj2-CHLORO-1-PROPANOLhttps://spectrabase.com/spectrum/2xgSay0kkbTVZIQXGLTRZLBEX-UHFFFAOYSA-Nhttps://spectrabase.com/spectrum/DuxxuH9V01N
- Springer Nature
- Wikidatapropylene chlorohydrinhttps://www.wikidata.org/wiki/Q15461615
- WikipediaPropylene chlorohydrinhttps://en.wikipedia.org/wiki/Propylene_chlorohydrin
- PubChem
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.html2-chloro-1-propanolhttps://www.ncbi.nlm.nih.gov/mesh/67053204
- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
- NORMAN Suspect List ExchangeLICENSEData: CC-BY 4.0; Code (hosted by ECI, LCSB): Artistic-2.0https://creativecommons.org/licenses/by/4.0/NORMAN Suspect List Exchange Classificationhttps://www.norman-network.com/nds/SLE/
- EPA Substance Registry ServicesEPA SRS List Classificationhttps://sor.epa.gov/sor_internet/registry/substreg/LandingPage.do
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 403380058https://pubchem.ncbi.nlm.nih.gov/substance/403380058