1,1,2,2-Tetrachloro-1,2-difluoroethane
- C2Cl4F2
- CCl2FCCl2F
- Cl2FCCCl2F
- 76-12-0
- 1,1,2,2-Tetrachloro-1,2-difluoroethane
- 1,2-Difluorotetrachloroethane
- Freon R 112
- Daiflon 112
- Create:2005-03-27
- Modify:2025-01-18
C2Cl4F2
Cl2FCCCl2F
- 76-12-0
- 1,1,2,2-Tetrachloro-1,2-difluoroethane
- 1,2-Difluorotetrachloroethane
- Freon R 112
- Daiflon 112
- Daiflon S2
- Refrigerant 112
- Halocarbon 112
- Tetrachloro-1,2-difluoroethane
- Genetron 112
- 1,2-Difluoro-1,1,2,2-tetrachloroethane
- sym-Tetrachlorodifluoroethane
- Ucon 112
- FREON 112
- Ethane, 1,1,2,2-tetrachloro-1,2-difluoro-
- CFC-112
- FC 112
- Ethane,1,1,2,2-tetrachloro-1,2-difluoro-
- F-112
- Ethane, 1,2-difluoro-1,1,2,2-tetrachloro-
- s-Tetrachlorodifluoroethane
- H155PU1V8F
- DTXSID5026091
- Fluorocarbon 112
- HSDB 144
- EINECS 200-935-6
- BRN 1740336
- UNII-H155PU1V8F
- 1,1,2,2-Tetrachlorodifluoroethane
- CFCl2CFCl2
- Difluorotetrachloroethane
- EC 200-935-6
- SCHEMBL74197
- DTXCID706091
- CHEMBL3186694
- UGCSPKPEHQEOSR-UHFFFAOYSA-
- Tox21_200566
- MFCD00039322
- CAS-76-12-0
- NCGC00248707-01
- NCGC00258120-01
- 1,2-Difluorotetrachloroethane (CFC-112)
- DB-056024
- NS00003480
- A838615
- InChI=1/C2Cl4F2/c3-1(4,7)2(5,6)8
- Q2806548
- 1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANE [HSDB]
- 1,1,2,2-tetrakis(chloranyl)-1,2-bis(fluoranyl)ethane
- The numbers in the "ODP1" column are from the Montreal Protocol. Some numbers have been updated as per amendments to the protocol. The "ODP2" column numbers are from the stratospheric ozone protection regulations at 40 CFR Part 82, as required by Title VI of the Clean Air Act amendments. These numbers include the amendments of July 18, 2003 (68 FR 42892). Data in the "ODP3" column come from WMO's /World Meteorological Organization/ Scientific Assessment of Ozone Depletion: 2006. ODP values listed are semi-empirical and can be found in Table 8-1 of the document. All GWP values represent global warming potential over a 100-year time horizon. The numbers in the "GWP1" column are from Table 1-6 of The Scientific Assessment of Ozone Depletion, 2002, a report of the World Meteorological Association's Global Ozone Research and Monitoring Project. The GWPs in the "GWP1" column that were not provided Table 1-6 of the 2002 report have not been updated since 1998 and are from The Scientific Assessment of Ozone Depletion, 1998. "GWP2" column numbers are from the Intergovernmental Panel on Climate Change Third Assessment Report: Climate Change 2001, and "GWP3" column numbers are from 40 CFR Part 82, stratospheric ozone protection regulations required by Title VI of the Clean Air Act amendments. The data in the "GWP4" column come from the IPCC Special Report on Safeguarding the Ozone Layer and the Global Climate System: Issues related to Hydrofluorocarbons and Perfluorocarbons ("SROC"). The values listed are for direct radiative forcing and can be found in Table 2.7 in the document. The numbers in the "GWP5" column come from the WMO's Scientific Assessment of Ozone Depletion: 2006. The values listed are for direct radiative forcing and can be found in Table 8-2 of the document.
- Table: Class I Ozone-depleting Substances Chemical NameLifetime, in yearsODP3 (WMO 2006)ODP2 (40 CFR 82)ODP1 (Montreal Protocol)GWP5( WMO 2006)GWP4 (SROC)GWP3 (40 CFR)GWP2 (TAR)GWP1 (WMO 2002)Chemical NameCFC-112 TetrachlorodifluoroethaneODP2 (40 CFR 82)1ODP1 (Montreal Protocol)1
P264, P270, P301+P317, P330, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 4 reports by companies from 2 notifications to the ECHA C&L Inventory.
Reported as not meeting GHS hazard criteria per 3 of 4 reports by companies. For more detailed information, please visit ECHA C&L website.
There is 1 notification provided by 1 of 4 reports by companies with hazard statement code(s).
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Skin corrosion/irritation - Category 2
Serious eye damage/eye irritation - Category 2B
Excerpt from NIOSH Pocket Guide for 1,1,2,2-Tetrachloro-1,2-difluoroethane:
Exposure Routes: Inhalation, ingestion, skin and/or eye contact
Symptoms: In Animals: irritation eyes, skin; conjunctivitis; pulmonary edema; narcosis
Target Organs: Eyes, skin, respiratory system, central nervous system (NIOSH, 2024)
Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:
Some may burn but none ignite readily. Containers may explode when heated. Ruptured cylinders may rocket. CAUTION: Aerosols (UN1950) may contain a flammable propellant. (ERG, 2024)
Excerpt from NIOSH Pocket Guide for 1,1,2,2-Tetrachloro-1,2-difluoroethane:
Eye: IRRIGATE IMMEDIATELY - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.
Skin: SOAP WASH PROMPTLY - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly.
Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.
Swallow: MEDICAL ATTENTION IMMEDIATELY - If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2024)
(See general first aid procedures)
Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.
Skin: Soap wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly.
Breathing: Respiratory support
Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.
Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:
Use extinguishing agent suitable for type of surrounding fire.
SMALL FIRE: Dry chemical or CO2.
LARGE FIRE: Water spray, fog or regular foam. If it can be done safely, move undamaged containers away from the area around the fire. Damaged cylinders should be handled only by specialists.
FIRE INVOLVING TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Do not direct water at source of leak or safety devices; icing may occur. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. Some of these materials, if spilled, may evaporate leaving a flammable residue. (ERG, 2024)
Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 100 meters (330 feet) in all directions.
LARGE SPILL: Consider initial downwind evacuation for at least 500 meters (1/3 mile).
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
Excerpt from ERG Guide 126 [Gases - Compressed or Liquefied (Including Refrigerant Gases)]:
Do not touch or walk through spilled material. Stop leak if you can do it without risk. Do not direct water at spill or source of leak. Use water spray to reduce vapors or divert vapor cloud drift. Avoid allowing water runoff to contact spilled material. If possible, turn leaking containers so that gas escapes rather than liquid. Prevent entry into waterways, sewers, basements or confined areas. Allow substance to evaporate. Ventilate the area. (ERG, 2024)
2000.0 [ppm]
Excerpts from Documentation for IDLHs: Other animal data: Rats exposed to 10,000 ppm for 1.5 to 2 hours showed slight signs of intoxication but no loss of reflexes, while 20,000 to 30,000 ppm was fatal in 1.0 to 2.5 hours [Greenberg and Lester 1950].
2000 ppm
See: 76120
Excerpt from NIOSH Pocket Guide for 1,1,2,2-Tetrachloro-1,2-difluoroethane:
Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.
Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.
Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.
Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced.
Change: No recommendation is made specifying the need for the worker to change clothing after the workshift. (NIOSH, 2024)
(See personal protection and sanitation codes)
Skin: Prevent skin contact - Wear appropriate personal protective clothing to prevent skin contact.
Eyes: Prevent eye contact - Wear appropriate eye protection to prevent eye contact.
Wash skin: When contaminated
Remove: When wet or contaminated
Change: No recommendation
NIOSH/OSHA
Up to 2000 ppm:
(APF = 10) Any supplied-air respirator
(APF = 50) Any self-contained breathing apparatus with a full facepiece
Emergency or planned entry into unknown concentrations or IDLH conditions:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape:
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister
Any appropriate escape-type, self-contained breathing apparatus
Neurotoxin - Acute solvent syndrome
Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=UGCSPKPEHQEOSR-UHFFFAOYSA-N
- Australian Industrial Chemicals Introduction Scheme (AICIS)Ethane, 1,1,2,2-tetrachloro-1,2-difluoro-https://services.industrialchemicals.gov.au/search-inventory/
- CAMEO ChemicalsLICENSECAMEO Chemicals and all other CAMEO products are available at no charge to those organizations and individuals (recipients) responsible for the safe handling of chemicals. However, some of the chemical data itself is subject to the copyright restrictions of the companies or organizations that provided the data.https://cameochemicals.noaa.gov/help/reference/terms_and_conditions.htm?d_f=false1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANEhttps://cameochemicals.noaa.gov/chemical/25072CAMEO Chemical Reactivity Classificationhttps://cameochemicals.noaa.gov/browse/react
- ILO-WHO International Chemical Safety Cards (ICSCs)1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANEhttps://www.ilo.org/dyn/icsc/showcard.display?p_version=2&p_card_id=1421
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/Tetrachloro-1,2-difluoroethanehttps://commonchemistry.cas.org/detail?cas_rn=76-12-0
- ChemIDplus1,1,2,2-Tetrachloro-1,2-difluoroethanehttps://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0000076120ChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- EPA Chemicals under the TSCAEthane, 1,1,2,2-tetrachloro-1,2-difluoro-https://www.epa.gov/chemicals-under-tscaEPA TSCA Classificationhttps://www.epa.gov/tsca-inventory
- EPA DSSTox1,2-Difluoro-1,1,2,2-tetrachloroethanehttps://comptox.epa.gov/dashboard/DTXSID5026091CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
- European Chemicals Agency (ECHA)LICENSEUse of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.https://echa.europa.eu/web/guest/legal-noticeTetrachloro-1,2-difluoroethanehttps://chem.echa.europa.eu/100.000.851Tetrachloro-1,2-difluoroethane (EC: 200-935-6)https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/95026
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- Hazardous Substances Data Bank (HSDB)1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANEhttps://pubchem.ncbi.nlm.nih.gov/source/hsdb/144
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- The National Institute for Occupational Safety and Health (NIOSH)LICENSEThe information provided using CDC Web site is only intended to be general summary information to the public. It is not intended to take the place of either the written law or regulations.https://www.cdc.gov/Other/disclaimer.htmlEthane, 1,2-difluoro-1,1,2,2-tetrachloro-https://www.cdc.gov/niosh-rtecs/KI15AAE0.html1,1,2,2-Tetrachloro-1,2-difluoroethanehttps://www.cdc.gov/niosh/npg/npgd0596.html
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- NITE-CMC1,1,2,2-Tetrachloro-1,2-difluoroethane (synonym: CFC-112) - FY2006 (New/original classication)https://www.chem-info.nite.go.jp/chem/english/ghs/06-imcg-0828e.html1,1,2,2-Tetrachloro-1,2-difluoroethane; CFC-112 - FY2022 (Revised classification)https://www.chem-info.nite.go.jp/chem/english/ghs/22-moe-2015e.html1,1,2,2-Tetrachloro-1,2-difluoroethane; CFC-112; R112 - FY2023 (Revised classification)https://www.chem-info.nite.go.jp/chem/english/ghs/23-jniosh-2001e.html
- Japan Chemical Substance Dictionary (Nikkaji)
- NIOSH Manual of Analytical MethodsLICENSEThe information provided using CDC Web site is only intended to be general summary information to the public. It is not intended to take the place of either the written law or regulations.https://www.cdc.gov/Other/disclaimer.html
- NIST Mass Spectrometry Data CenterLICENSEData covered by the Standard Reference Data Act of 1968 as amended.https://www.nist.gov/srd/public-lawEthane, 1,1,2,2-tetrachloro-1,2-difluoro-http://www.nist.gov/srd/nist1a.cfm
- SpectraBaseEthane, 1,1,2,2-tetrachloro-1,2-difluoro-https://spectrabase.com/spectrum/DWGUlnr0S2DEthane, 1,1,2,2-tetrachloro-1,2-difluoro-https://spectrabase.com/spectrum/HSXmMerSNRy1,1,2,2-TETRACHLORODIFLUOROETHANEhttps://spectrabase.com/spectrum/Ea7dR5UdW8B1,2-DIFLUORO-1,1,2,2-TETRACHLOROETHANEhttps://spectrabase.com/spectrum/LNLdyyBbgmlETHANE, 1,2-DIFLUORO-1,1,2,2-TETRA- CHLORO-,https://spectrabase.com/spectrum/7yuNFMp3I7D1,1,2,2-TETRACHLORO-1,2-DIFLUOROETHANEhttps://spectrabase.com/spectrum/1u8GUeykce01,1,2,2-TETRACHLORO-1,2-DIFLUORO-ETHANEhttps://spectrabase.com/spectrum/IFODVQjak4U1,1,2,2-Tetrachlorodifluoroethanehttps://spectrabase.com/spectrum/Bzv5V536pmDETHANE, 1,1,2,2-TETRACHLORO-1,2-DIFLUORO-https://spectrabase.com/spectrum/6LLZtVpSc501,1,2,2-Tetrachloro-1,2-difluoro-ethanehttps://spectrabase.com/spectrum/IpCjdU1w1M0
- NMRShiftDB
- Springer Nature
- SpringerMaterialstetrachloro-1,2-difluoroethanehttps://materials.springer.com/substanceprofile/docs/smsid_cmlepdoihdpwtkxz
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- Wikidata1,2-difluoro-1,1,2,2-tetrachloroethanehttps://www.wikidata.org/wiki/Q2806548
- WikipediaTetrachloro-1,2-difluoroethanehttps://en.wikipedia.org/wiki/Tetrachloro-1,2-difluoroethane
- PubChemPFAS and Fluorinated Compounds in PubChemhttps://gitlab.com/uniluxembourg/lcsb/eci/pubchem-docs/-/raw/main/pfas-tree/PFAS_Tree.pdf?inline=false
- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
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- PATENTSCOPE (WIPO)SID 403419162https://pubchem.ncbi.nlm.nih.gov/substance/403419162
- NCBI