Fosamax
- ALENDRONATE SODIUM
- 129318-43-0
- Fosamax
- Binosto
- Fosamac
- Create:2007-11-13
- Modify:2025-01-18
- 4-Amino-1-Hydroxybutylidene 1,1-Biphosphonate
- Alendronate
- Alendronate Monosodium Salt, Trihydrate
- Alendronate Sodium
- Aminohydroxybutane Bisphosphonate
- Fosamax
- MK 217
- MK-217
- MK217
- ALENDRONATE SODIUM
- 129318-43-0
- Fosamax
- Binosto
- Fosamac
- Onclast
- Monosodium alendronate
- Osteovan
- Indrol
- Alend
- alendronate monosodium
- NeoBon
- Alendronate sodium anhydrous
- MK 217
- sodium;(4-amino-1-hydroxy-1-phosphonobutyl)-hydroxyphosphinate
- Alendronic Acid Monosodium Salt
- MK-217
- Adrovance
- G-704650
- Vantavo
- Onclast; Osteovan; Sodium alendronate
- 4988K7X26P
- UNII-4988K7X26P
- (4-Amino-1-hydroxybutylidene)bisphosphonic acid monosodium salt
- Phosphonic acid, (4-amino-1-hydroxybutylidene)bis-, monosodium salt
- Alendronate sodium hydrate
- DTXSID70904501
- SODIUM ALENDRONATE ANHYDROUS
- NSC-722597
- NSC-758931
- Almerol
- Avalent
- Bonalon
- Steovess
- Teiroc
- AHButBP
- AHBuBP
- MFCD01861681
- 4-AMINO-1-HYDROXYBUTYLIDENE-1,1-BISPHOSPHONIC ACID MONOSODIUM SALT
- PHOSPHONIC ACID, P,P'-(4-AMINO-1-HYDROXYBUTYLIDENE)BIS-, SODIUM SALT (1:1)
- CHEMBL675
- Alendronic acid sodium salt
- GTH-42J
- GTH-42V
- GTH-42W
- SCHEMBL328770
- GTH-42
- MER-103
- HMS3604I12
- HMS3713P04
- BCP28464
- Alendronic acid, Sodium aldendronate
- BDBM50247920
- EX-101
- AKOS015895071
- SODIUM HYDROGEN (4-AMINO-1-HYDROXY-1-PHOSPHONOBUTYL)PHOSPHONATE
- CCG-220631
- KS-1028
- MK-0217
- DA-60905
- HY-108685
- A2456
- CS-0029477
- MK 217;MK-217;MK217;Sodium alendronate
- G70854
- EN300-7373370
- J-005667
- L-670452
- Q27259256
- Monosodium (4-Amino-1-hydroxy-1-phosphonobutyl)phosphonate
- sodium hydrogen-4-amino-1-hydroxy-1-phosphonobutylphosphonate
- (4-Amino-1-hydroxy-1-phosphonobutyl)phosphonic Acid Monosodium Salt
◉ Summary of Use during Lactation
Limited evidence indicates that breastfeeding after cessation of long-term bisphosphonate treatment appears to have no adverse effects on the infant. Because no information is available on the use of alendronate during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. However, absorption of alendronate by a breastfed infant is unlikely. If the mother receives a bisphosphonate during pregnancy or nursing, some experts recommend monitoring the infant's serum calcium during the first 2 months postpartum.
◉ Effects in Breastfed Infants
Because alendronate can persist in the body for years after long-term administration, the following cases may be relevant. A woman received alendronate for 6 months, then pamidronate every 4 months for 1 year prior to conception. Her infant was breastfed (extent not stated) for 3 months. The infant had mild hypocalcemia at 2 months of age, but a normal calcium level and normal long bone development at 5 months of age.
◉ Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=CAKRAHQRJGUPIG-UHFFFAOYSA-M
- CCSbaseCCSbase Classificationhttps://ccsbase.net/
- ChEMBLLICENSEAccess to the web interface of ChEMBL is made under the EBI's Terms of Use (http://www.ebi.ac.uk/Information/termsofuse.html). The ChEMBL data is made available on a Creative Commons Attribution-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-sa/3.0/).http://www.ebi.ac.uk/Information/termsofuse.htmlChEMBL Protein Target Treehttps://www.ebi.ac.uk/chembl/g/#browse/targets
- ChemIDplusChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- EPA Chemicals under the TSCAPhosphonic acid, P,P'-(4-amino-1-hydroxybutylidene)bis-, sodium salt (1:1)https://www.epa.gov/chemicals-under-tscaEPA TSCA Classificationhttps://www.epa.gov/tsca-inventory
- EPA DSSToxAlendronate sodium anhydroushttps://comptox.epa.gov/dashboard/DTXSID70904501CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
- FDA Global Substance Registration System (GSRS)LICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linkingALENDRONATE SODIUM ANHYDROUShttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/4988K7X26P
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- Drugs and Lactation Database (LactMed)
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- European Medicines Agency (EMA)LICENSEInformation on the European Medicines Agency's (EMA) website is subject to a disclaimer and copyright and limited reproduction notices.https://www.ema.europa.eu/en/about-us/legal-noticeAdrovance (EMEA/H/C/000759)https://www.ema.europa.eu/en/medicines/human/EPAR/adrovance
- EU Clinical Trials Register
- Open TargetsLICENSEDatasets generated by the Open Targets Platform are freely available for download.https://platform-docs.opentargets.org/licenceALENDRONATE SODIUMhttps://platform.opentargets.org/drug/CHEMBL675
- FDA Medication GuidesLICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linkingFOSAMAXhttps://dps.fda.gov/medguide
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- NIPH Clinical Trials Search of Japan
- NLM RxNorm TerminologyLICENSEThe RxNorm Terminology is created by the National Library of Medicine (NLM) and is in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from NLM. Credit to the U.S. National Library of Medicine as the source is appreciated but not required. The full RxNorm dataset requires a free license.https://www.nlm.nih.gov/research/umls/rxnorm/docs/termsofservice.htmlalendronate sodiumhttps://rxnav.nlm.nih.gov/id/rxnorm/203152
- Thieme ChemistryLICENSEThe Thieme Chemistry contribution within PubChem is provided under a CC-BY-NC-ND 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc-nd/4.0/
- Wikidataalendronate sodiumhttps://www.wikidata.org/wiki/Q27259256
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.htmlAlendronatehttps://www.ncbi.nlm.nih.gov/mesh/68019386Bone Density Conservation Agentshttps://www.ncbi.nlm.nih.gov/mesh/68050071
- PubChem
- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
- National Drug Code (NDC) DirectoryLICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linkingFDA Drug Type and Pharmacologic Classificationhttps://www.fda.gov/drugs/drug-approvals-and-databases/national-drug-code-directory
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 389003264https://pubchem.ncbi.nlm.nih.gov/substance/389003264