10-Formyltetrahydropteroylglutamic acid
PubChem CID
135450591
Structure
Molecular Formula
Synonyms
- 2800-34-2
- 10-Formyltetrahydrofolic acid
- 10-formyltetrahydropteroylglutamic acid
- 10-Fthf
- 10-Formyltetrahydrofolate
Molecular Weight
473.4 g/mol
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Dates
- Create:2019-01-15
- Modify:2025-01-18
Description
N10-Formyl-THF is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
10-Formyltetrahydropteroylglutamic acid has been reported in Arabidopsis thaliana and Phaseolus vulgaris with data available.
N10-Formyl-THF is a metabolite found in or produced by Saccharomyces cerevisiae.
Chemical Structure Depiction
(2S)-2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl)methyl-formylamino]benzoyl]amino]pentanedioic acid
Computed by Lexichem TK 2.7.0 (PubChem release 2021.10.14)
InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/t11?,13-/m0/s1
Computed by InChI 1.0.6 (PubChem release 2021.10.14)
AUFGTPPARQZWDO-YUZLPWPTSA-N
Computed by InChI 1.0.6 (PubChem release 2021.10.14)
C1C(NC2=C(N1)N=C(NC2=O)N)CN(C=O)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Computed by OEChem 2.3.0 (PubChem release 2024.12.12)
C20H23N7O7
Computed by PubChem 2.2 (PubChem release 2021.10.14)
- 10-formyl-THF
- 10-formyltetrahydrofolate
- 10-formyltetrahydropteroylglutamic acid
- 10-FTHF
- 2800-34-2
- 10-Formyltetrahydrofolic acid
- 10-formyltetrahydropteroylglutamic acid
- 10-Fthf
- 10-Formyltetrahydrofolate
- N10-formyl-THF
- 10-formyl-tetrahydrofolate
- 10-formyl-THF
- n10-formyltetrahydrofolate
- 43SUG29HQR
- 10-Formyl-5,6,7,8-tetrahydrofolic acid
- N10-Formyltetrahydropteroylglutamate
- CID 122347
- 10-Formyl-(6RS)-tetrahydrofolic acid
- (2S)-2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-1H-pteridin-6-yl)methyl-formylamino]benzoyl]amino]pentanedioic acid
- (2S)-2-(4-(N-((2-Amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)formamido)benzamido)pentanedioic acid
- (2S)-2-[[4-[(2-amino-4-oxo-5,6,7,8-tetrahydro-3H-pteridin-6-yl)methyl-formylamino]benzoyl]amino]pentanedioic acid
- 10-formyl-H4PteGlu1
- 2-[4-[(2-AMINO-4-OXO-5,6,7,8-TETRAHYDRO-1H-PTERIDIN-6-YL)METHYL-FORMYL-AMINO]BENZOYL]AMINOPENTANEDIOIC ACID
- N10-formyl-H4F
- UNII-43SUG29HQR
- N10-Formyltetrahydrofolic acid
- SCHEMBL13418310
- DTXSID60903987
- AUFGTPPARQZWDO-YUZLPWPTSA-N
- 10-formyltetrahydropteroylglutamate
- AKOS037503834
- N10-Formyl-5,6,7,8-tetrahydrofolate
- HY-112169
- N10-Formyl-5,6,7,8-tetrahydrofolic acid
- CS-0043593
- 10-Formyltetrahydrofolate (1 stereocenter specified)
- Q47459238
- (2S)-2-(4-(N-((2-Amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)formamido)benzamido)pentanedioicacid
- (2S)-2-[(4-{N-[(2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]formamido}phenyl)formamido]pentanedioic acid
- Glutamic acid, N-[p-[N-[(2-amino-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]formamido]benzoyl]- (7CI)
- Glutamic acid, N-[p-[N-[(2-amino-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]formamido]benzoyl]-, L-
- Glutamic acid, N-[p-[N-[(2-amino-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]formamido]benzoyl]-, L- (8CI)
- L-Glutamic acid, N-(4-(((2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6 pteridinyl)methyl)formylamino)benzoyl)-
- L-Glutamic acid, N-(4-(((2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)formylamino)benzoyl)-
- L-Glutamic acid, N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]formylamino]benzoyl]- (9CI)
- L-Glutamic acid, N-[4-[[(2-amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]formylamino]benzoyl]-
- N-[4-[[(2-Amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]formylamino]benzoyl]-L-glutamic acid
- N-[p-[N-[(2-amino-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]formamido]benzoyl]-Glutamate
- N-[p-[N-[(2-amino-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]formamido]benzoyl]-Glutamic acid
- N-[p-[N-[(2-amino-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]formamido]benzoyl]-L-Glutamate
- N-[p-[N-[(2-amino-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]formamido]benzoyl]-L-Glutamic acid
Property Name
Property Value
Reference
Property Name
Molecular Weight
Property Value
473.4 g/mol
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
XLogP3-AA
Property Value
-1.2
Reference
Computed by XLogP3 3.0 (PubChem release 2021.10.14)
Property Name
Hydrogen Bond Donor Count
Property Value
7
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Hydrogen Bond Acceptor Count
Property Value
10
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Rotatable Bond Count
Property Value
9
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Exact Mass
Property Value
473.16589610 Da
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Monoisotopic Mass
Property Value
473.16589610 Da
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Topological Polar Surface Area
Property Value
216 Ų
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Heavy Atom Count
Property Value
34
Reference
Computed by PubChem
Property Name
Formal Charge
Property Value
0
Reference
Computed by PubChem
Property Name
Complexity
Property Value
911
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Isotope Atom Count
Property Value
0
Reference
Computed by PubChem
Property Name
Defined Atom Stereocenter Count
Property Value
1
Reference
Computed by PubChem
Property Name
Undefined Atom Stereocenter Count
Property Value
1
Reference
Computed by PubChem
Property Name
Defined Bond Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Undefined Bond Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Covalently-Bonded Unit Count
Property Value
1
Reference
Computed by PubChem
Property Name
Compound Is Canonicalized
Property Value
Yes
Reference
Computed by PubChem (release 2021.10.14)
Solid
Follow these links to do a live 2D search or do a live 3D search for this compound, sorted by annotation score. This section is deprecated (see here for details), but these live search links provide equivalent functionality to the table that was previously shown here.
Same Connectivity Count
Same Stereo Count
Same Isotope Count
Same Parent, Connectivity Count
Same Parent, Stereo Count
Same Parent, Isotope Count
Same Parent, Exact Count
Mixtures, Components, and Neutralized Forms Count
Similar Compounds (2D)
Similar Conformers (3D)
- Extracellular
- Lysosome
- Mitochondria
- Adenine phosphoribosyltransferase deficiency (APRT)
- Adenosine Deaminase Deficiency
- Adenylosuccinate Lyase Deficiency
- AICA-Ribosiduria
- Azathioprine Action Pathway
- Cystathionine Beta-Synthase Deficiency
- Folate malabsorption, hereditary
- Glycine N-methyltransferase Deficiency
- Gout or Kelley-Seegmiller Syndrome
- Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type
- Total 29 pathways, visit the HMDB page for details
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=AUFGTPPARQZWDO-YUZLPWPTSA-N
Zebrafish Pathway Metabolite MetFrag Local CSV (Beta) | DOI:10.5281/zenodo.3457553
The LOTUS Initiative for Open Natural Products Research: frozen dataset union wikidata (with metadata) | DOI:10.5281/zenodo.5794106
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/10-Formyltetrahydrofolatehttps://commonchemistry.cas.org/detail?cas_rn=2800-34-2
- ChemIDplus10-Formyltetrahydropteroylglutamic acidhttps://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0002800342ChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- EPA DSSTox10-Formyltetrahydropteroylglutamic acidhttps://comptox.epa.gov/dashboard/DTXSID60903987CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
- FDA Global Substance Registration System (GSRS)LICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linking10-Formyltetrahydrofolic acidhttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/43SUG29HQR
- Human Metabolome Database (HMDB)LICENSEHMDB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (HMDB) and the original publication (see the HMDB citing page). We ask that users who download significant portions of the database cite the HMDB paper in any resulting publications.http://www.hmdb.ca/citing10-Formyltetrahydrofolatehttp://www.hmdb.ca/metabolites/HMDB0000972
- Comparative Toxicogenomics Database (CTD)LICENSEIt is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.http://ctdbase.org/about/legal.jsp10-formyltetrahydropteroylglutamic acidhttps://ctdbase.org/detail.go?type=chem&acc=C010161
- E. coli Metabolome Database (ECMDB)
- LOTUS - the natural products occurrence databaseLICENSEThe code for LOTUS is released under the GNU General Public License v3.0.https://lotus.nprod.net/10-Formyltetrahydropteroylglutamic acidhttps://www.wikidata.org/wiki/Q47459238LOTUS Treehttps://lotus.naturalproducts.net/
- Yeast Metabolome Database (YMDB)N10-Formyl-THFhttps://www.ymdb.ca/compounds/YMDB00080
- ECI Group, LCSB, University of Luxembourg10-Formyltetrahydropteroylglutamic acid
- KNApSAcK Species-Metabolite Database10-Formyltetrahydrofolatehttp://www.knapsackfamily.com/knapsack_core/info.php?sname=C_ID&word=C00052533
- FooDBLICENSEFooDB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (FooDB) and the original publication.https://foodb.ca/about10-formyl-tetrahydrofolatehttps://foodb.ca/compounds/FDB030256
- Japan Chemical Substance Dictionary (Nikkaji)
- Metabolomics Workbench10-formyltetrahydrofolic acidhttps://www.metabolomicsworkbench.org/data/StructureData.php?RegNo=50196
- Nature Chemical Biology
- Springer Nature
- Wikidata(2S)-10-formyltetrahydropteroyl-ξ-glutamic acidhttps://www.wikidata.org/wiki/Q47459238
- Wikipedia10-Formyltetrahydrofolatehttps://en.wikipedia.org/wiki/10-Formyltetrahydrofolate
- PubChem
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.html10-formyltetrahydropteroylglutamic acidhttps://www.ncbi.nlm.nih.gov/mesh/67010161
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 388741210https://pubchem.ncbi.nlm.nih.gov/substance/388741210
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