Safinamide
- Safinamide
- 133865-89-1
- (S)-2-((4-((3-Fluorobenzyl)oxy)benzyl)amino)propanamide
- Xadago
- (2S)-2-[[4-[(3-Fluorophenyl)methoxy]phenyl]methylamino]propanamide
- Create:2005-08-08
- Modify:2025-01-11
- (S)-2-((4-(3-fluorobenzoxy)benzyl)amino)propanamide
- 2-(4-(3-fluorobenzyloxy)benzylamino)propionamide
- fbap methanesulfonate
- FCE 26743
- FCE 28073
- FCE-26743
- FCE-28073
- NW-1015
- PNU 151774E
- PNU-151774E
- safinamide
- safinamide methanesulfonate
- Xadago
- Safinamide
- 133865-89-1
- (S)-2-((4-((3-Fluorobenzyl)oxy)benzyl)amino)propanamide
- Xadago
- (2S)-2-[[4-[(3-Fluorophenyl)methoxy]phenyl]methylamino]propanamide
- EMD 1195686
- EMD-1195686
- UNII-90ENL74SIG
- 90ENL74SIG
- Fce-26743
- 2-(4-(3-Fluorobenzyloxy)benzylamino)propionamide
- CHEMBL396778
- EC 603-772-2
- (S)-2-(((4-((3-Fluorophenyl)methoxy)phenyl)methyl)amino)propanamide
- DTXSID601010282
- (2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl)amino]propanamide
- N2-(4-((3-Fluorbenzyl)oxy)benzyl)-L-alaninamid
- (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide
- CHEMBL48582
- Propanamide, 2-(((4-((3-fluorophenyl)methoxy)phenyl)methyl)amino)-, (S)-
- Safinamide [USAN:INN]
- safinamidum
- Safinamida
- MFCD00897036
- Safinamide (Standard)
- SAFINAMIDE [MI]
- SAFINAMIDE [INN]
- Safinamide (USAN/INN)
- SAFINAMIDE [USAN]
- SAFINAMIDE [WHO-DD]
- SCHEMBL69350
- 2(s)-(4-(3-fluorobenzyloxy)benzylamino)propionamide
- GTPL8291
- BDBM19187
- N04BD03
- CHEBI:134718
- NEMGRZFTLSKBAP-LBPRGKRZSA-N
- DTXCID701436700
- HMS3886M21
- BCP12082
- EX-A2759
- BDBM50078694
- HY-70057R
- s5357
- AKOS016002015
- CCG-267489
- CS-0556
- DB06654
- ER-0076
- NCGC00346529-01
- NCGC00346529-03
- NCGC00346529-05
- AC-26829
- DA-67371
- HY-70057
- 5139B
- NS00001226
- S0935
- D10158
- EN300-18567503
- (S)-2[4-(3-fluorobenzyloxy)benzylamino]propanamide
- J-506604
- Q2211523
- (5)-2-[4-(3-fluorobenzyloxy)benzylamino]propanamide
- (S)-2-((4-(3-fluorobenzoxy)benzyl)amino)propanamide
- (S)-2-[4-(3-fluorobenzyloxy)benzylamino]propanamide
- (S)-2[4-(3-fluorobenzyloxy)benzylamino] propanamide
- BRD-K92613113-066-02-7
- (2S)-2-[4-(3-fluorobenzyloxy)benzylamino]propionamide
- 2(S)-[4-(3-Fluorobenzyloxy) benzylamino] propionamide
- (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propionamide
- (+-)-(S)-2-((p-((m-Fluorobenzyl)oxy)benzyl)amino)propionamide
- (S)-2-[4-(3-Fluoro-benzyloxy)-benzylamino]-propionamide; compound with methanesulfonic acid
- EMD 1195686;FCE 26743;EMD-1195686;EMD1195686;FCE-26743
H301 (90.5%): Toxic if swallowed [Danger Acute toxicity, oral]
H318 (90.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
H400 (90.5%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
P264, P264+P265, P270, P273, P280, P301+P316, P305+P354+P338, P317, P321, P330, P391, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 42 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Acute Tox. 3 (90.5%)
Eye Dam. 1 (90.5%)
Aquatic Acute 1 (90.5%)
Safinamide has been reported to cause serum enzyme elevations in a small proportion of patients treated long term, although the abnormalities were usually mild and self-limiting and were usually no more frequent than with placebo or comparator agents. Safinamide has not been implicated in cases of acute liver injury, but such instances have been reported with nonspecific MAO inhibitors.
Likelihood score: E (unlikely cause of clinically apparent liver injury).
◉ Summary of Use during Lactation
No information is available on the use of safinamide during breastfeeding. Because of liver toxicity in nursing rat pups, the manufacturer recommends that the drug not be used in nursing mothers. Alternate agents are preferred.
◉ Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=NEMGRZFTLSKBAP-LBPRGKRZSA-N
- Avoid excessive or chronic alcohol consumption. Ingesting alcohol may increase the sedative effects of safinamide.
- Avoid St. John's Wort. This herb may increase the risk of serotonin syndrome, and therefore, concomitant use is contraindicated.
- Avoid tyramine-containing foods and supplements. Avoid foods containing high amounts of tyramine (>150mg) as these foods may cause a significant elevation in blood pressure. Tyramine-containing foods include cheese, red wine, fava beans, pickled food, cured food, and alcoholic beverages.
- Take at the same time every day.
- Take with or without food.
- BindingDBLICENSEAll data curated by BindingDB staff are provided under the Creative Commons Attribution 3.0 License (https://creativecommons.org/licenses/by/3.0/us/).https://www.bindingdb.org/rwd/bind/info.jsp(2S)-2-[({4-[(3-fluorophenyl)methoxy]phenyl}methyl)amino]propanamidehttps://www.bindingdb.org/rwd/bind/chemsearch/marvin/MolStructure.jsp?monomerid=19187
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- DrugBankLICENSECreative Common's Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/legalcode)https://www.drugbank.ca/legal/terms_of_useSafinamidehttps://www.drugbank.ca/drugs/DB06654
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- ChemIDplusSafinamide [USAN:INN]https://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0133865891ChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
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- LiverTox
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- The Cambridge Structural Database
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- EU Clinical Trials Register
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- Japan Chemical Substance Dictionary (Nikkaji)
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- Metabolomics Workbench
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- Wikidatasafinamidehttps://www.wikidata.org/wiki/Q2211523
- Wikipedia2.2.2-Cryptandhttps://en.wikipedia.org/wiki/2.2.2-CryptandSafinamidehttps://en.wikipedia.org/wiki/Safinamide
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- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 388897999https://pubchem.ncbi.nlm.nih.gov/substance/388897999