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BioActivity Data for Compound Carbon Tetrachloride (CID 5943)

BioActivity Outcomes:
Active(6)
 
 
Inactive(550)
 
 
Inconclusive(13)
 
 
Unspecified(2166)
 
 
Top Targets:
7tm 4(33)
 
 
 
NR LBD ER(20)
 
 
 
NR LBD PPAR(20)
 
 
 
NR LBD AR(19)
 
 
 
 
p450(16)
 
 
 
 
BioAssay Types:
Confirmatory(554)
 
 
 
 
 
Literature(76)
 
 
 
Summary(39)
 
 
 
Screening(2)
 
 
BioAssay Categories:
In vitro(132)
 
 
 
In vivo(2024)
 
 
 
Biochemical(133)
 
 
 
 
Toxicity(2098)
 
 
 
ADME(8)
 
 
 
Cell-based(83)
 
 
 
BioActivity Types:
Potency(397)
 
 
 
IC50(117)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2440    Data Row: 2735   Total Pages: 137   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103226142]
IC50 11DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625250, Type: confirmatory]Cytochrome P450 2E1 [gi:117250]
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2
[SID48413382]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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3
[SID48413382]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Mouse Bioassay Results [AID1199, Type: other]
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4
[SID48413382]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results [AID1205, Type: other]
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5
[SID48413382]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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6
[SID85229934]
Ligands of peptide (Class A) GPCRs [AID2063, Type: other]
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7
[SID103226142]
Partition coefficient (logP) [AID19825, Type: Literature]
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8
[SID103226142]
Induction of aneuploidy in Aspergillus nidulans. [AID37562, Type: Literature]
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9
[SID103226142]
Toxicity determined using Microtox Test [AID159270, Type: Literature]
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10
[SID103226142]
Binding affinity to beta cyclodextrin [AID346025, Type: Literature]
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11
[SID103226142]
IC50 DRUGMATRIX: Imidazoline I2, Central radioligand binding (ligand: [3H] Idazoxan) [AID625272, Type: confirmatory]
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12
[SID103226142]
Literature-mined public compounds from Lowe et al phospholipidosis modelling dataset [AID588208, Type: Literature]
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13
[SID103226142]
Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset [AID588209, Type: Literature]
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14
[SID103226142]
Human drug-induced liver injury (DILI) modelling dataset from Ekins et al [AID588210, Type: Literature]
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15
[SID103226142]
IC50 Cytotoxicity against human HepG2 cells after 24 hrs assessed as inhibition of cell viability by MTT assay [AID592714, Type: Literature]
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16
[SID103226142]
Octanol-water partition coefficient, log P of the compound [AID603957, Type: Literature]
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17
[SID103226142]
IC50 DRUGMATRIX: Nicotinic Acetylcholine radioligand binding (ligand: [125I] Epibatidine) [AID625158, Type: confirmatory]
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18
[SID103226142]
DRUGMATRIX: Phorbol Ester radioligand binding (ligand: [3H] PDBu) [AID625164, Type: other]
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19
[SID103226142]
IC50 DRUGMATRIX: Phosphodiesterase PDE3 enzyme inhibition (substrate: [3H]cAMP + cAMP) [AID625165, Type: confirmatory]
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20
[SID103226142]
IC50 DRUGMATRIX: Phosphodiesterase PDE4 enzyme inhibition (substrate: [3H]cAMP + cAMP) [AID625166, Type: confirmatory]
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