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Compound Summary for: CID 457193


Also known as: actinomycin D; Cosmegen; Meractinomycin; UNII-1CC1JFE158; Actinomycin; Dactinomicina; Dactinomycine; Dactinomycinum
Molecular Formula: C62H86N12O16   Molecular Weight: 1255.41704   InChIKey: RJURFGZVJUQBHK-IIXSONLDSA-N
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)   From: MeSH
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