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Compound Summary for: CID 37393


Also known as: Halofantrina; 69756-53-2; Halfan; Halofantrine [USAN]; Halofantrinum; (1)-Halofantrine; dl-WR 171669; AC1L1XMN
Molecular Formula: C26H30Cl2F3NO   Molecular Weight: 500.42371   InChIKey: FOHHNHSLJDZUGQ-UHFFFAOYSA-N
Halofantrine is a drug used to treat malaria. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferentially block open and inactivated HERG channels leading to some degree of cardiotoxicity.   From: DrugBank
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