Bookmark and Share

Compound Summary for: CID 9926791


Also known as: Tasocitinib; 477600-75-2; CP-690550; CP 690550
Molecular Formula: C16H20N6O   Molecular Weight: 312.3696   InChIKey: UJLAWZDWDVHWOW-YPMHNXCESA-N
Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signaling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant to methotrexate. Besides rheumatoid arthritis, tofacitinib has also been studied in clinical trials for the prevention of organ transplant rejection, and the treatment of psoriasis and ulcerative colitis. Known adverse effects include nausea and headache as well as more serious immunologic and hematological adverse effects. Tofacitinib is marketed under the brand name Xeljanz.    From: DrugBank
Show subcontent titlesTable of Contents
Related Records
show all 3 sub-sections (Related Compounds with Annotation, Related Compounds, Related Substances)
Use and Manufacturing
Biomolecular Interactions and Pathways
Biological Test Results
Chemical and Physical Properties
_ _