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Compound Summary for: CID 9848818

tauroursodeoxycholic acid

Also known as: TUDCA; Tauroursodeoxycholate; 14605-22-2; Sodium tauroursodeoxycholate; CHEMBL272427; Tauroursodeoxycholic acid sodium salt
Molecular Formula: C26H45NO6S   Molecular Weight: 499.7036   InChIKey: BHTRKEVKTKCXOH-LBSADWJPSA-N
Tauroursodeoxycholic acid is the more hydrophilic form of ursodeoxycholic acid, which is the more abundant naturally produced bile acid in humans. Tauroursodeoxycholic acid, on the other hand, is produced abundantly in bears and has been used for centuries as a natural remedy in some Asian countries. It is approved in Italy and Turkey for the treatment of cholesterol gallstones and is an investigational drug in China, Unites States, and Italy. Tauroursodeoxycholic acid is being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis. The only completed clinical trial thus far is a phase III clinical trial comparing tauroursodeoxycholic acid and ursofalk in PBC adult patients, but as of June 2013 no results of this trial have been published.    From: DrugBank
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