68506460 -OEChem-04242423592D 74 76 0 1 0 0 0 0 0999 V2000 11.4102 0.6200 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 6.3772 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.6182 12.7543 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.9461 0.6200 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0 11.4102 8.6200 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.4160 5.6442 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.4160 3.5958 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 13.2468 9.6145 0.0000 N 0 0 3 0 0 0 0 0 0 0 0 0 12.2762 7.1200 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 9.6782 5.6200 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 7.9461 5.6200 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.8121 4.1200 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 7.9461 2.6200 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 11.4102 6.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1423 8.6200 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 14.0558 8.2133 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4102 5.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5442 7.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.7249 8.9564 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.2249 9.8224 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5442 5.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6782 6.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2762 8.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.5036 10.2837 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8121 5.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0801 5.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9461 3.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0801 4.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1861 5.6547 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1861 3.5853 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2801 5.1408 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2801 4.0992 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8121 2.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8121 1.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6782 2.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6782 0.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5442 2.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4198 6.6441 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5480 4.0925 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5442 1.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9471 6.3100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.6223 8.9577 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7458 7.6763 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 14.5574 7.8488 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.6223 5.0374 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0208 5.7277 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9427 7.5950 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1457 7.5950 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 15.1398 8.4957 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2265 9.3208 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7913 10.0746 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 14.0333 10.4121 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1457 4.6450 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9427 4.6450 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4661 7.2026 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0676 6.5123 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.8132 6.8100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.9185 10.7444 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0429 10.6985 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0888 9.8229 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1933 6.2746 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1933 2.9654 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4092 2.3100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6782 3.2400 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6782 0.0000 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0811 2.4300 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0398 6.6418 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4222 7.2641 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7998 6.6465 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8560 4.6306 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0099 4.4004 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2401 3.5544 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0000 6.3772 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6182 12.7543 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1 40 1 0 0 0 0 2 73 1 0 0 0 0 3 74 1 0 0 0 0 4 34 1 0 0 0 0 5 23 2 0 0 0 0 6 31 1 0 0 0 0 6 38 1 0 0 0 0 7 32 1 0 0 0 0 7 39 1 0 0 0 0 8 15 1 0 0 0 0 8 20 1 0 0 0 0 8 24 1 0 0 0 0 9 14 1 0 0 0 0 9 23 1 0 0 0 0 9 57 1 0 0 0 0 10 21 1 0 0 0 0 10 22 1 0 0 0 0 10 25 1 0 0 0 0 11 25 2 0 0 0 0 11 26 1 0 0 0 0 12 25 1 0 0 0 0 12 27 2 0 0 0 0 13 27 1 0 0 0 0 13 33 1 0 0 0 0 13 63 1 0 0 0 0 14 17 1 0 0 0 0 14 18 1 0 0 0 0 14 41 1 0 0 0 0 15 16 1 0 0 0 0 15 23 1 1 0 0 0 15 42 1 0 0 0 0 16 19 1 0 0 0 0 16 43 1 0 0 0 0 16 44 1 0 0 0 0 17 21 1 0 0 0 0 17 45 1 0 0 0 0 17 46 1 0 0 0 0 18 22 1 0 0 0 0 18 47 1 0 0 0 0 18 48 1 0 0 0 0 19 20 1 0 0 0 0 19 49 1 0 0 0 0 19 50 1 0 0 0 0 20 51 1 0 0 0 0 20 52 1 0 0 0 0 21 53 1 0 0 0 0 21 54 1 0 0 0 0 22 55 1 0 0 0 0 22 56 1 0 0 0 0 24 58 1 0 0 0 0 24 59 1 0 0 0 0 24 60 1 0 0 0 0 26 28 1 0 0 0 0 26 29 2 0 0 0 0 27 28 1 0 0 0 0 28 30 2 0 0 0 0 29 31 1 0 0 0 0 29 61 1 0 0 0 0 30 32 1 0 0 0 0 30 62 1 0 0 0 0 31 32 2 0 0 0 0 33 34 2 0 0 0 0 33 35 1 0 0 0 0 34 36 1 0 0 0 0 35 37 2 0 0 0 0 35 64 1 0 0 0 0 36 40 2 0 0 0 0 36 65 1 0 0 0 0 37 40 1 0 0 0 0 37 66 1 0 0 0 0 38 67 1 0 0 0 0 38 68 1 0 0 0 0 38 69 1 0 0 0 0 39 70 1 0 0 0 0 39 71 1 0 0 0 0 39 72 1 0 0 0 0 M END > 68506460 > 1 > 792 > 9 > 4 > 7 > AAADcfB7sQAGAAAAAAAAAAAAAAAAAWAAAAA8eIEAAAAAAACx9AAAHwIQAAAADC7Bni4z9vfIFACoAydydACCiCkhJ6AJmKG+7piNbvLF+/uUNCpu1hvK6Ce40RMOIEBBAgACQABAgIIEAASAAAAAAAAAAA== > (2S)-N-[1-[4-(4-chloro-2-fluoro-anilino)-6,7-dimethoxy-quinazolin-2-yl]-4-piperidyl]-1-methyl-pyrrolidine-2-carboxamide;dihydrochloride > (2S)-N-[1-[4-(4-chloro-2-fluoroanilino)-6,7-dimethoxy-2-quinazolinyl]-4-piperidinyl]-1-methyl-2-pyrrolidinecarboxamide;dihydrochloride > (2S)-N-[1-[4-(4-chloro-2-fluoroanilino)-6,7-dimethoxyquinazolin-2-yl]piperidin-4-yl]-1-methylpyrrolidine-2-carboxamide;dihydrochloride > (2S)-N-[1-[4-(4-chloro-2-fluoroanilino)-6,7-dimethoxyquinazolin-2-yl]piperidin-4-yl]-1-methylpyrrolidine-2-carboxamide;dihydrochloride > (2S)-N-[1-[4-[(4-chloranyl-2-fluoranyl-phenyl)amino]-6,7-dimethoxy-quinazolin-2-yl]piperidin-4-yl]-1-methyl-pyrrolidine-2-carboxamide;dihydrochloride > (2S)-N-[1-[4-(4-chloro-2-fluoro-anilino)-6,7-dimethoxy-quinazolin-2-yl]-4-piperidyl]-1-methyl-pyrrolidine-2-carboxamide;dihydrochloride > InChI=1S/C27H32ClFN6O3.2ClH/c1-34-10-4-5-22(34)26(36)30-17-8-11-35(12-9-17)27-32-21-15-24(38-3)23(37-2)14-18(21)25(33-27)31-20-7-6-16(28)13-19(20)29;;/h6-7,13-15,17,22H,4-5,8-12H2,1-3H3,(H,30,36)(H,31,32,33);2*1H/t22-;;/m0../s1 > QGOGZDIQYQMOTQ-IKXQUJFKSA-N > 614.174200 > C27H34Cl3FN6O3 > 615.9 > CN1CCCC1C(=O)NC2CCN(CC2)C3=NC4=CC(=C(C=C4C(=N3)NC5=C(C=C(C=C5)Cl)F)OC)OC.Cl.Cl > CN1CCC[C@H]1C(=O)NC2CCN(CC2)C3=NC4=CC(=C(C=C4C(=N3)NC5=C(C=C(C=C5)Cl)F)OC)OC.Cl.Cl > 91.8 > 614.174200 > 0 > 40 > 1 > 0 > 0 > 0 > 0 > 3 > -1 > 1 5 255 > 11 25 8 11 26 8 12 25 8 12 27 8 15 23 5 26 28 8 26 29 8 27 28 8 28 30 8 29 31 8 30 32 8 31 32 8 33 34 8 33 35 8 34 36 8 35 37 8 36 40 8 37 40 8 $$$$