68506459 -OEChem-05062402402D 74 76 0 1 0 0 0 0 0999 V2000 11.4102 0.6200 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 6.2110 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.6182 12.4220 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 7.9461 0.6200 0.0000 F 0 0 0 0 0 0 0 0 0 0 0 0 11.4102 8.6200 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.4160 5.6442 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.4160 3.5958 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 12.2762 7.1200 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 9.6782 5.6200 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 13.2468 9.6145 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 7.9461 5.6200 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.8121 4.1200 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 7.9461 2.6200 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 11.4102 6.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.4102 5.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5442 7.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5442 5.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6782 6.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1423 8.6200 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 14.0558 8.2133 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 12.2762 8.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.7249 8.9564 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 14.2249 9.8224 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 13.1423 6.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8121 5.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0801 5.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.9461 3.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.0801 4.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1861 5.6547 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1861 3.5853 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2801 5.1408 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2801 4.0992 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8121 2.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.8121 1.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6782 2.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.4198 6.6441 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.6782 0.6200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5442 2.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.5480 4.0925 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.5442 1.1200 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.9471 6.3100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.6223 5.0374 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.0208 5.7277 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9427 7.5950 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1457 7.5950 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.1457 4.6450 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9427 4.6450 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.4661 7.2026 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.0676 6.5123 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.6223 8.9577 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.7458 7.6763 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 14.5574 7.8488 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 15.1398 8.4957 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 15.2265 9.3208 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 14.7913 10.0746 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 14.0333 10.4121 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.7860 10.0294 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.8323 6.0831 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.6792 6.3100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 13.4523 7.1569 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1933 6.2746 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1933 2.9654 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4092 2.3100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6782 3.2400 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.0398 6.6418 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4222 7.2641 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7998 6.6465 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6782 0.0000 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.0811 2.4300 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.8560 4.6306 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0099 4.4004 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.2401 3.5544 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.0000 6.2110 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6182 12.4220 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1 40 1 0 0 0 0 2 73 1 0 0 0 0 3 74 1 0 0 0 0 4 34 1 0 0 0 0 5 21 2 0 0 0 0 6 31 1 0 0 0 0 6 36 1 0 0 0 0 7 32 1 0 0 0 0 7 39 1 0 0 0 0 8 14 1 0 0 0 0 8 21 1 0 0 0 0 8 24 1 0 0 0 0 9 17 1 0 0 0 0 9 18 1 0 0 0 0 9 25 1 0 0 0 0 10 19 1 0 0 0 0 10 23 1 0 0 0 0 10 57 1 0 0 0 0 11 25 2 0 0 0 0 11 26 1 0 0 0 0 12 25 1 0 0 0 0 12 27 2 0 0 0 0 13 27 1 0 0 0 0 13 33 1 0 0 0 0 13 63 1 0 0 0 0 14 15 1 0 0 0 0 14 16 1 0 0 0 0 14 41 1 0 0 0 0 15 17 1 0 0 0 0 15 42 1 0 0 0 0 15 43 1 0 0 0 0 16 18 1 0 0 0 0 16 44 1 0 0 0 0 16 45 1 0 0 0 0 17 46 1 0 0 0 0 17 47 1 0 0 0 0 18 48 1 0 0 0 0 18 49 1 0 0 0 0 19 20 1 0 0 0 0 19 21 1 1 0 0 0 19 50 1 0 0 0 0 20 22 1 0 0 0 0 20 51 1 0 0 0 0 20 52 1 0 0 0 0 22 23 1 0 0 0 0 22 53 1 0 0 0 0 22 54 1 0 0 0 0 23 55 1 0 0 0 0 23 56 1 0 0 0 0 24 58 1 0 0 0 0 24 59 1 0 0 0 0 24 60 1 0 0 0 0 26 28 1 0 0 0 0 26 29 2 0 0 0 0 27 28 1 0 0 0 0 28 30 2 0 0 0 0 29 31 1 0 0 0 0 29 61 1 0 0 0 0 30 32 1 0 0 0 0 30 62 1 0 0 0 0 31 32 2 0 0 0 0 33 34 2 0 0 0 0 33 35 1 0 0 0 0 34 37 1 0 0 0 0 35 38 2 0 0 0 0 35 64 1 0 0 0 0 36 65 1 0 0 0 0 36 66 1 0 0 0 0 36 67 1 0 0 0 0 37 40 2 0 0 0 0 37 68 1 0 0 0 0 38 40 1 0 0 0 0 38 69 1 0 0 0 0 39 70 1 0 0 0 0 39 71 1 0 0 0 0 39 72 1 0 0 0 0 M END > 68506459 > 1 > 792 > 9 > 4 > 7 > AAADcfB7sQAGAAAAAAAAAAAAAAAAAWAAAAA8eIEAAAAAAACx9AAAHwIQAAAADC7Bni4z9vfIFACoAydydACCiCkhJ6AJmKG+7piNbvLF+/uUNCpu1hvK6Ce40RMOIEBBAgACQABAgIIEAASAAAAAAAAAAA== > (2S)-N-[1-[4-(4-chloro-2-fluoro-anilino)-6,7-dimethoxy-quinazolin-2-yl]-4-piperidyl]-N-methyl-pyrrolidine-2-carboxamide;dihydrochloride > (2S)-N-[1-[4-(4-chloro-2-fluoroanilino)-6,7-dimethoxy-2-quinazolinyl]-4-piperidinyl]-N-methyl-2-pyrrolidinecarboxamide;dihydrochloride > (2S)-N-[1-[4-(4-chloro-2-fluoroanilino)-6,7-dimethoxyquinazolin-2-yl]piperidin-4-yl]-N-methylpyrrolidine-2-carboxamide;dihydrochloride > (2S)-N-[1-[4-(4-chloro-2-fluoroanilino)-6,7-dimethoxyquinazolin-2-yl]piperidin-4-yl]-N-methylpyrrolidine-2-carboxamide;dihydrochloride > (2S)-N-[1-[4-[(4-chloranyl-2-fluoranyl-phenyl)amino]-6,7-dimethoxy-quinazolin-2-yl]piperidin-4-yl]-N-methyl-pyrrolidine-2-carboxamide;dihydrochloride > (2S)-N-[1-[4-(4-chloro-2-fluoro-anilino)-6,7-dimethoxy-quinazolin-2-yl]-4-piperidyl]-N-methyl-pyrrolidine-2-carboxamide;dihydrochloride > InChI=1S/C27H32ClFN6O3.2ClH/c1-34(26(36)21-5-4-10-30-21)17-8-11-35(12-9-17)27-32-22-15-24(38-3)23(37-2)14-18(22)25(33-27)31-20-7-6-16(28)13-19(20)29;;/h6-7,13-15,17,21,30H,4-5,8-12H2,1-3H3,(H,31,32,33);2*1H/t21-;;/m0../s1 > GEJYPQZTJPNGSI-FGJQBABTSA-N > 614.174200 > C27H34Cl3FN6O3 > 615.9 > CN(C1CCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4=C(C=C(C=C4)Cl)F)OC)OC)C(=O)C5CCCN5.Cl.Cl > CN(C1CCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4=C(C=C(C=C4)Cl)F)OC)OC)C(=O)[C@@H]5CCCN5.Cl.Cl > 91.8 > 614.174200 > 0 > 40 > 1 > 0 > 0 > 0 > 0 > 3 > -1 > 1 5 255 > 11 25 8 11 26 8 12 25 8 12 27 8 19 21 5 26 28 8 26 29 8 27 28 8 28 30 8 29 31 8 30 32 8 31 32 8 33 34 8 33 35 8 34 37 8 35 38 8 37 40 8 38 40 8 $$$$