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Compound Summary for: CID 637568

dimethyl fumarate

Also known as: 624-49-7; Fumaric acid, dimethyl ester; Fumaderm; Methyl fumarate; 2-Butenedioic acid (E)-, dimethyl ester
Molecular Formula: C6H8O4   Molecular Weight: 144.12532   InChIKey: LDCRTTXIJACKKU-ONEGZZNKSA-N
Dimethyl fumarate is an anti-inflammatory. It is indicated for multiple sclerosis patients with relapsing forms and is also being investigated for the treatment of psoriasis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress. Dimethyl fumarate is marketed under the brand name Tecfidera.   From: DrugBank
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