60186796 -OEChem-03292401162D 74 79 0 1 0 0 0 0 0999 V2000 6.3966 3.6230 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 8.9946 3.1230 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2.4110 -0.0106 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 12.3094 2.4594 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.2626 -1.8770 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.1286 1.6230 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.4503 1.9277 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 9.8606 1.6230 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 11.8094 3.3254 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 7.2626 0.1230 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3966 -0.3770 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1286 -0.3770 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1286 -3.3770 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3966 0.6230 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1286 0.6230 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3966 -1.3770 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1286 -1.3770 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2626 -2.8770 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.6286 -4.2430 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.1286 -3.3770 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3966 1.6230 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2626 2.1230 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 5.4503 0.3183 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8667 1.1230 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2626 3.1230 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9946 2.1230 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0430 -0.6337 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1397 2.8783 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8353 1.0316 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0140 -0.7490 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4060 0.0893 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.7267 2.1230 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.6402 1.7163 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8312 3.1175 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 -0.9222 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 11.8481 0.7381 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.0881 3.7867 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.1845 0.2056 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7860 -0.4846 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7392 -0.4846 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3406 0.2056 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.2891 -2.7781 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3406 0.0404 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7392 0.7307 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7860 -1.2693 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1845 -1.9596 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3406 -1.9596 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7392 -1.2693 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6520 -2.7693 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0505 -3.4596 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1537 -4.6415 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.1036 -4.6415 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.7112 -3.5890 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.2363 -2.7664 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7995 2.4330 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.8732 3.0154 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4746 3.7056 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4128 -1.1314 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7290 3.0709 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9471 3.4676 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5504 2.6856 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4771 1.5376 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7635 -1.3161 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8606 1.0030 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.3966 4.2430 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4348 -0.6673 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7452 -1.4874 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5652 -1.1770 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.2417 0.6092 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.9770 0.1317 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 12.4546 0.8670 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.5029 4.2474 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6273 4.2015 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6732 3.3259 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1 25 1 0 0 0 0 1 65 1 0 0 0 0 2 26 2 0 0 0 0 3 31 1 0 0 0 0 3 35 1 0 0 0 0 4 9 1 0 0 0 0 4 33 1 0 0 0 0 5 16 1 0 0 0 0 5 17 1 0 0 0 0 5 18 1 0 0 0 0 6 15 1 0 0 0 0 6 22 1 0 0 0 0 6 26 1 0 0 0 0 7 21 1 0 0 0 0 7 24 1 0 0 0 0 7 28 1 0 0 0 0 8 26 1 0 0 0 0 8 32 1 0 0 0 0 8 64 1 0 0 0 0 9 34 2 0 0 0 0 10 11 1 0 0 0 0 10 12 1 0 0 0 0 10 14 1 0 0 0 0 10 15 1 0 0 0 0 11 16 1 0 0 0 0 11 38 1 0 0 0 0 11 39 1 0 0 0 0 12 17 1 0 0 0 0 12 40 1 0 0 0 0 12 41 1 0 0 0 0 13 18 1 0 0 0 0 13 19 1 0 0 0 0 13 20 1 0 0 0 0 13 42 1 0 0 0 0 14 21 2 0 0 0 0 14 23 1 0 0 0 0 15 43 1 0 0 0 0 15 44 1 0 0 0 0 16 45 1 0 0 0 0 16 46 1 0 0 0 0 17 47 1 0 0 0 0 17 48 1 0 0 0 0 18 49 1 0 0 0 0 18 50 1 0 0 0 0 19 20 1 0 0 0 0 19 51 1 0 0 0 0 19 52 1 0 0 0 0 20 53 1 0 0 0 0 20 54 1 0 0 0 0 21 22 1 0 0 0 0 22 25 1 6 0 0 0 22 55 1 0 0 0 0 23 24 2 0 0 0 0 23 27 1 0 0 0 0 24 29 1 0 0 0 0 25 56 1 0 0 0 0 25 57 1 0 0 0 0 27 30 2 0 0 0 0 27 58 1 0 0 0 0 28 59 1 0 0 0 0 28 60 1 0 0 0 0 28 61 1 0 0 0 0 29 31 2 0 0 0 0 29 62 1 0 0 0 0 30 31 1 0 0 0 0 30 63 1 0 0 0 0 32 33 2 0 0 0 0 32 34 1 0 0 0 0 33 36 1 0 0 0 0 34 37 1 0 0 0 0 35 66 1 0 0 0 0 35 67 1 0 0 0 0 35 68 1 0 0 0 0 36 69 1 0 0 0 0 36 70 1 0 0 0 0 36 71 1 0 0 0 0 37 72 1 0 0 0 0 37 73 1 0 0 0 0 37 74 1 0 0 0 0 M END > 60186796 > 1 > 833 > 6 > 2 > 5 > AAADcfB7uAAAAAAAAAAAAAAAGAAAAWLAAAA8WIAAAAAAAFgB/AAAHgAUCAAADyzhngYzxvPcFgCpA6RyVgCCiCAlMiAo2CG/fNqOdvrEsbuUcahuxpvY6WeQ0PMPoAAAAgACAABAAAAEAAQAAAAAAAAAAA== > (1R)-1'-(cyclopropylmethyl)-N-(3,5-dimethylisoxazol-4-yl)-1-(hydroxymethyl)-7-methoxy-9-methyl-spiro[1,3-dihydropyrido[3,4-b]indole-4,4'-piperidine]-2-carboxamide > (1R)-1'-(cyclopropylmethyl)-N-(3,5-dimethyl-4-isoxazolyl)-1-(hydroxymethyl)-7-methoxy-9-methyl-2-spiro[1,3-dihydropyrido[3,4-b]indole-4,4'-piperidine]carboxamide > (1R)-1'-(cyclopropylmethyl)-N-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(hydroxymethyl)-7-methoxy-9-methylspiro[1,3-dihydropyrido[3,4-b]indole-4,4'-piperidine]-2-carboxamide > (1R)-1'-(cyclopropylmethyl)-N-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(hydroxymethyl)-7-methoxy-9-methylspiro[1,3-dihydropyrido[3,4-b]indole-4,4'-piperidine]-2-carboxamide > (1R)-1'-(cyclopropylmethyl)-N-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(hydroxymethyl)-7-methoxy-9-methyl-spiro[1,3-dihydropyrido[3,4-b]indole-4,4'-piperidine]-2-carboxamide > (1R)-1'-(cyclopropylmethyl)-N-(3,5-dimethylisoxazol-4-yl)-7-methoxy-9-methyl-1-methylol-spiro[1,3-dihydro-beta-carboline-4,4'-piperidine]-2-carboxamide > InChI=1S/C28H37N5O4/c1-17-25(18(2)37-30-17)29-27(35)33-16-28(9-11-32(12-10-28)14-19-5-6-19)24-21-8-7-20(36-4)13-22(21)31(3)26(24)23(33)15-34/h7-8,13,19,23,34H,5-6,9-12,14-16H2,1-4H3,(H,29,35)/t23-/m0/s1 > OWFKIMYUTRLCSJ-QHCPKHFHSA-N > 2.4 > 507.28455468 > C28H37N5O4 > 507.6 > CC1=C(C(=NO1)C)NC(=O)N2CC3(CCN(CC3)CC4CC4)C5=C(C2CO)N(C6=C5C=CC(=C6)OC)C > CC1=C(C(=NO1)C)NC(=O)N2CC3(CCN(CC3)CC4CC4)C5=C([C@@H]2CO)N(C6=C5C=CC(=C6)OC)C > 96 > 507.28455468 > 0 > 37 > 1 > 0 > 0 > 0 > 0 > 1 > -1 > 1 5 255 > 14 21 8 14 23 8 22 25 6 23 24 8 23 27 8 24 29 8 27 30 8 29 31 8 30 31 8 32 33 8 32 34 8 4 33 8 4 9 8 7 21 8 7 24 8 9 34 8 $$$$