60186757 -OEChem-04232410132D 74 79 0 1 0 0 0 0 0999 V2000 8.1286 4.4594 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 6.3966 -2.5406 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2.4110 0.8258 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 7.6286 -5.0794 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 8.1286 2.4594 0.0000 N 0 0 3 0 0 0 0 0 0 0 0 0 5.4503 2.7642 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 7.2626 -1.0406 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.1286 -2.5406 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.6286 -5.0794 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 7.2626 0.9594 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1286 1.4594 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8606 2.4594 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3966 1.4594 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2626 2.9594 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 8.9946 2.9594 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3966 0.4594 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1286 0.4594 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.3607 1.5934 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 10.8607 2.4594 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3966 2.4594 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3966 -0.5406 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1286 -0.5406 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4503 1.1547 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2626 3.9594 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.8667 1.9594 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0430 0.2027 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.1397 3.7147 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8353 1.8680 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.2626 -2.0406 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0140 0.0874 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.4060 0.9257 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.1286 -3.5406 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 -0.0858 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.3196 -4.1284 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9376 -4.1284 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3685 -3.8194 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 9.8887 -3.8194 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.3406 0.8768 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7392 1.5671 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0211 3.0583 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.7995 3.2694 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.3932 3.4344 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.5961 3.4344 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1845 1.0420 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7860 0.3518 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7392 0.3518 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3406 1.0420 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.8857 1.1949 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.8356 1.1949 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 11.4433 2.2474 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.9683 3.0700 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7860 -0.4329 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1845 -1.1232 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.3406 -1.1232 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.7392 -0.4329 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.0505 4.5420 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6520 3.8518 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4128 -0.2949 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7290 3.9073 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.9471 4.3040 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.5504 3.5221 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.4771 2.3740 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7635 -0.4797 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.1286 5.0794 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8.6655 -2.2306 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.4348 0.1691 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.7452 -0.6510 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.5652 -0.3406 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.5601 -3.2297 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.7789 -3.6278 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.1769 -4.4090 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.0803 -4.4090 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 10.4783 -3.6278 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 9.6971 -3.2297 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1 24 1 0 0 0 0 1 64 1 0 0 0 0 2 29 2 0 0 0 0 3 31 1 0 0 0 0 3 33 1 0 0 0 0 4 9 1 0 0 0 0 4 34 1 0 0 0 0 5 11 1 0 0 0 0 5 14 1 0 0 0 0 5 15 1 0 0 0 0 6 20 1 0 0 0 0 6 25 1 0 0 0 0 6 27 1 0 0 0 0 7 21 1 0 0 0 0 7 22 1 0 0 0 0 7 29 1 0 0 0 0 8 29 1 0 0 0 0 8 32 1 0 0 0 0 8 65 1 0 0 0 0 9 35 2 0 0 0 0 10 11 1 0 0 0 0 10 13 1 0 0 0 0 10 16 1 0 0 0 0 10 17 1 0 0 0 0 11 38 1 0 0 0 0 11 39 1 0 0 0 0 12 15 1 0 0 0 0 12 18 1 0 0 0 0 12 19 1 0 0 0 0 12 40 1 0 0 0 0 13 20 2 0 0 0 0 13 23 1 0 0 0 0 14 20 1 0 0 0 0 14 24 1 6 0 0 0 14 41 1 0 0 0 0 15 42 1 0 0 0 0 15 43 1 0 0 0 0 16 21 1 0 0 0 0 16 44 1 0 0 0 0 16 45 1 0 0 0 0 17 22 1 0 0 0 0 17 46 1 0 0 0 0 17 47 1 0 0 0 0 18 19 1 0 0 0 0 18 48 1 0 0 0 0 18 49 1 0 0 0 0 19 50 1 0 0 0 0 19 51 1 0 0 0 0 21 52 1 0 0 0 0 21 53 1 0 0 0 0 22 54 1 0 0 0 0 22 55 1 0 0 0 0 23 25 2 0 0 0 0 23 26 1 0 0 0 0 24 56 1 0 0 0 0 24 57 1 0 0 0 0 25 28 1 0 0 0 0 26 30 2 0 0 0 0 26 58 1 0 0 0 0 27 59 1 0 0 0 0 27 60 1 0 0 0 0 27 61 1 0 0 0 0 28 31 2 0 0 0 0 28 62 1 0 0 0 0 30 31 1 0 0 0 0 30 63 1 0 0 0 0 32 34 2 0 0 0 0 32 35 1 0 0 0 0 33 66 1 0 0 0 0 33 67 1 0 0 0 0 33 68 1 0 0 0 0 34 36 1 0 0 0 0 35 37 1 0 0 0 0 36 69 1 0 0 0 0 36 70 1 0 0 0 0 36 71 1 0 0 0 0 37 72 1 0 0 0 0 37 73 1 0 0 0 0 37 74 1 0 0 0 0 M END > 60186757 > 1 > 833 > 6 > 2 > 5 > AAADcfB7uAAAAAAAAAAAAAAAGAAAAWLAAAA8WIAAAAAAAFgB/AAAHgAUCAAADyzhngYzxvPcFgCpA6RyVgCCiCAlMiAo2CG/fNqOdvrEsbuUcahuxpvY6WeQ0PMPoAAAAgACAABAAAAEAAQAAAAAAAAAAA== > (1R)-2-(cyclopropylmethyl)-N-(3,5-dimethylisoxazol-4-yl)-1-(hydroxymethyl)-7-methoxy-9-methyl-spiro[1,3-dihydropyrido[3,4-b]indole-4,4'-piperidine]-1'-carboxamide > (1R)-2-(cyclopropylmethyl)-N-(3,5-dimethyl-4-isoxazolyl)-1-(hydroxymethyl)-7-methoxy-9-methyl-1'-spiro[1,3-dihydropyrido[3,4-b]indole-4,4'-piperidine]carboxamide > (1R)-2-(cyclopropylmethyl)-N-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(hydroxymethyl)-7-methoxy-9-methylspiro[1,3-dihydropyrido[3,4-b]indole-4,4'-piperidine]-1'-carboxamide > (1R)-2-(cyclopropylmethyl)-N-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(hydroxymethyl)-7-methoxy-9-methylspiro[1,3-dihydropyrido[3,4-b]indole-4,4'-piperidine]-1'-carboxamide > (1R)-2-(cyclopropylmethyl)-N-(3,5-dimethyl-1,2-oxazol-4-yl)-1-(hydroxymethyl)-7-methoxy-9-methyl-spiro[1,3-dihydropyrido[3,4-b]indole-4,4'-piperidine]-1'-carboxamide > (1R)-2-(cyclopropylmethyl)-N-(3,5-dimethylisoxazol-4-yl)-7-methoxy-9-methyl-1-methylol-spiro[1,3-dihydro-beta-carboline-4,4'-piperidine]-1'-carboxamide > InChI=1S/C28H37N5O4/c1-17-25(18(2)37-30-17)29-27(35)32-11-9-28(10-12-32)16-33(14-19-5-6-19)23(15-34)26-24(28)21-8-7-20(36-4)13-22(21)31(26)3/h7-8,13,19,23,34H,5-6,9-12,14-16H2,1-4H3,(H,29,35)/t23-/m0/s1 > UMZMETCWXDFGRE-QHCPKHFHSA-N > 2.4 > 507.28455468 > C28H37N5O4 > 507.6 > CC1=C(C(=NO1)C)NC(=O)N2CCC3(CC2)CN(C(C4=C3C5=C(N4C)C=C(C=C5)OC)CO)CC6CC6 > CC1=C(C(=NO1)C)NC(=O)N2CCC3(CC2)CN([C@H](C4=C3C5=C(N4C)C=C(C=C5)OC)CO)CC6CC6 > 96 > 507.28455468 > 0 > 37 > 1 > 0 > 0 > 0 > 0 > 1 > -1 > 1 5 255 > 13 20 8 13 23 8 14 24 6 23 25 8 23 26 8 25 28 8 26 30 8 28 31 8 30 31 8 32 34 8 32 35 8 4 34 8 4 9 8 6 20 8 6 25 8 9 35 8 $$$$