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Compound Summary for: CID 56842206

Transforming Growth Factor beta

Also known as: Tgfbeta; Milk growth factor; TGF-Beta; Platelet Transforming Growth Factor; GC 1008; Bone-Derived Transforming Growth Factor
Molecular Formula: C211H345N61O62S   Molecular Weight: 4760.4335   InChIKey: ZRKFYGHZFMAOKI-QMGMOQQFSA-N
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.   From: MeSH
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