Trimethoprim - PubChem

Trimethoprim - Compound Summary (CID 5578) Also known as: Proloprim, Trimpex, Bactramin, Monotrim, Monotrimin, Syraprim, Trimopan, 738-70-5, Sulfamethoprim Molecular Formula: C₁₄H₁₈N₄O₃ Molecular Weight: 290.31772 InChIKey: IEDVJHCEMCRBQM-UHFFFAOYSA-N A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. The interference with folic acid metabolism may cause a depression of hematopoiesis. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported. From: MeSH View the conformer with web-based 3D viewer View the conformer with Pc3D viewer application Download Pc3D viewer application 2D ASN.1 Text: Display 2D ASN.1 Text: Save 2D ASN.1 Binary: Save 3D ASN.1 Text: Display 3D ASN.1 Text: Save 3D ASN.1 Binary: Save 2D XML: Display 2D XML: Save 3D XML: Display 3D XML: Save 2D SDF: Display 2D SDF: Save 3D SDF: Display 3D SDF: Save BioActivity, this compound BioActivity, with similar compounds BioActivity, with similar conformers
Show subcontent titlesHide subcontent titlesTable of Contents Identification Depositor-Supplied Synonyms Compound Information Related Records Related Compounds with Annotation Related Compounds Related Substances Use and Manufacturing Medication Information Patents Methods of Manufacturing Formulations/Preparations Use and Manufacturing References Pharmacology Pharmacological Action Therapeutic Uses Drug Warning Drug Tolerance Biomedical Effects and Toxicity Absorption, Distribution and Excretion Metabolism/Metabolites Biological Half-Life Mechanism of Action Interactions Antidote and Emergency Treatment Human Toxicity Excerpts Non-Human Toxicity Excerpts Non-Human Toxicity Values Toxicology References Safety and Handling Decomposition Stability/Shelf Life Storage Conditions Disposal Methods Environmental Fate and Exposure Potential Environmental Fate/Exposure Summary Artificial Sources Environmental Fate Biodegredation Abiotic Degredation Bioconcentration Soil Adsorption/Mobility Volatilization from Water/Soil Water Concentrations Effluents Concentrations Milk Concentrations Probable Routes of Human Exposure Average Daily Intake Body Burdens Exposure Standards and Regulations FDA Requirements Monitoring and Analysis Methods Analytic Laboratory Methods Clinical Laboratory Methods Literature Depositor Provided PubMed Citations NLM Curated PubMed Citations Patents Depositor-Supplied Patent Identifiers Biomolecular Interactions and Pathways Protein Bound 3-D Structures Interactions Target Enzyme Transporter Action General Function Specific Function Gene Name GenBank Gene GenBank Protein References Biological Test Results BioAssay Results Classification Ontologies Substance Categorization Classification Chemical and Physical Properties Color/Form Odor Taste Dissociation Constants Octanol/Water Partition Coefficient Solubilities Computed Properties Expand all sub-sections	2D Structure 3D Conformer
Identification Help top of page Related Records Help top of page show all 3 sub-sections (Related Compounds with Annotation, Related Compounds, Related Substances)show first sub-section only Use and Manufacturing Help top of page show all 5 sub-sections (Medication Information, Patents, Methods of Manufacturing, Formulations/Preparations ...)show first sub-section only Pharmacology Help top of page show all 4 sub-sections (Pharmacological Action, Therapeutic Uses, Drug Warning, Drug Tolerance)show first sub-section only Biomedical Effects and Toxicity Help top of page show all 10 sub-sections (Absorption, Distribution and Excretion, Metabolism/Metabolites, Biological Half-Life ...)show first sub-section only Safety and Handling Help top of page show all 4 sub-sections (Decomposition, Stability/Shelf Life, Storage Conditions, Disposal Methods)show first sub-section only Environmental Fate and Exposure Potential Help top of page show all 14 sub-sections (Environmental Fate/Exposure Summary, Artificial Sources, Environmental Fate, Biodegredation ...)show first sub-section only Exposure Standards and Regulations Help top of page Monitoring and Analysis Methods Help top of page show all 2 sub-sections (Analytic Laboratory Methods, Clinical Laboratory Methods)show first sub-section only Literature Help top of page show all 2 sub-sections (Depositor Provided PubMed Citations, NLM Curated PubMed Citations)show first sub-section only Patents Help top of page Biomolecular Interactions and Pathways Help top of page show all 2 sub-sections (Protein Bound 3-D Structures, Interactions)show first sub-section only Biological Test Results Help top of page Data Analysis Data Download BioActivity Summary: This Compound with Similar Compounds with Similar Conformers Classification Help top of page show all 2 sub-sections (Ontologies, Substance Categorization Classification)show first sub-section only Chemical and Physical Properties Help top of page show all 7 sub-sections (Color/Form, Odor, Taste, Dissociation Constants, Octanol/Water Partition Coefficient ...)show first sub-section only

_