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Compound Summary for: CID 5426


Also known as: Thalomid; 50-35-1; Distaval; Softenon; Talimol; Contergan; Sedoval; N-Phthaloylglutamimide; Corronarobetin
Molecular Formula: C13H10N2O4   Molecular Weight: 258.2295   InChIKey: UEJJHQNACJXSKW-UHFFFAOYSA-N
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.   From: MeSH
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