Bookmark and Share

Compound Summary for: CID 5396


Also known as: 29767-20-2; AC1L1K9H; Neuro_000056; MLS000766234; SMR000528847; SureCN13809319; AGN-PC-015IA1; CTK8E8745; AG-K-54054
Molecular Formula: C32H32O13S   Molecular Weight: 656.65368   InChIKey: NRUKOCRGYNPUPR-UHFFFAOYSA-N
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.   From: MeSH
Show subcontent titlesTable of Contents
Related Records
show all 3 sub-sections (Related Compounds with Annotation, Related Compounds, Related Substances)
Use and Manufacturing
Biomedical Effects and Toxicity
Safety and Handling
Exposure Standards and Regulations
Monitoring and Analysis Methods
Biomolecular Interactions and Pathways
Biological Test Results
Chemical and Physical Properties
_ _