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Compound Summary for: CID 5353588

Diosmine

Also known as: 3',5,7-Trihydroxy-4'-methoxy-flavone 7-rutinoside; 520-27-4; SMR000112431
Molecular Formula: C28H32O15   Molecular Weight: 608.54468   InChIKey: GZSOSUNBTXMUFQ-UHFFFAOYSA-N
Diosmin is semisynthetic drug (modified hesperidin). It is an oral phlebotropic drug used in the treatment of venous disease, i.e., chronic venous insufficiency (CVI) and hemorrhoidal disease (HD), in acute or chronic hemorrhoids, in place of rubber-band ligation, in combination with fiber supplement, or as an adjuvant therapy to hemorrhoidectomy, in order to reduce secondary bleeding. To control internal symptoms of hemorrhoids (piles), it is used with hesperidin. Clinical studies have been inconclusive and no review articles on its use in vascular disease have been published. Diosmin is currently a prescription medication in some European countries, and is sold as a nutritional supplement in the United States and the rest of Europe. Diosmin has been found to be effective in mitigating hyperglycemia in diabetic rats. It is also speculated that diosmin might have potential in the treatment of neurodegenerative diseases, such as Alzheimer's disease, and its anti-inflammatory and anti-apoptotic activity has been demonstrated in neuronal cells, in vitro.   From: DrugBank
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