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Compound Summary for: CID 5329102

sunitinib

Also known as: Sutent; SU-11248; 557795-19-4; sunitinibum; SU11248; Sunitinib (INN); Su-011248; SU 11248; UNII-V99T50803M
Molecular Formula: C22H27FN4O2   Molecular Weight: 398.473783   InChIKey: WINHZLLDWRZWRT-ATVHPVEESA-N
Sunitinib is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. Sunitinib inhibits cellular signaling by targeting multiple RTKs. These include all platelet-derived growth factor receptors (PDGF-R) and vascular endothelial growth factor receptors (VEGF-R). Sunitinib also inhibits KIT (CD117), the RTK that drives the majority of GISTs. In addition, sunitinib inhibits other RTKs including RET, CSF-1R, and flt3.   From: DrugBank
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