52952316 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 16 16 16 16 16 16 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 8 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 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116 117 117 117 118 118 118 119 119 119 120 120 120 121 121 121 122 122 122 123 123 124 124 125 127 127 128 128 129 129 129 130 130 130 131 131 131 133 134 134 135 135 137 137 137 138 138 138 139 140 141 141 142 142 143 143 145 145 146 146 146 147 148 148 148 149 149 150 150 150 151 151 151 152 153 153 154 154 156 156 157 157 158 158 158 160 162 162 163 163 163 165 165 166 166 166 167 167 167 168 168 169 169 169 171 171 171 172 172 172 173 173 173 175 175 175 176 176 176 178 178 178 179 179 182 183 183 184 184 186 186 186 187 187 187 188 188 190 190 190 192 192 193 193 193 194 194 194 195 195 195 196 196 196 197 199 199 199 201 201 202 202 204 204 204 206 206 207 207 208 208 209 209 210 5 141 4 143 6 153 168 175 165 93 94 95 97 106 108 113 126 298 125 126 132 133 136 140 142 312 144 147 152 156 344 155 157 345 159 160 161 164 170 174 177 180 181 182 185 188 380 189 192 383 191 197 200 203 393 203 205 84 87 93 86 92 97 91 94 226 98 101 106 95 103 237 102 125 246 108 115 247 112 114 256 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329 330 332 333 334 180 336 337 178 338 339 179 340 341 181 342 343 183 347 348 185 349 184 350 351 188 352 190 191 357 189 192 358 194 359 195 362 363 199 368 196 200 369 370 371 372 203 373 374 202 375 376 201 377 378 379 381 382 206 207 205 387 388 208 391 209 392 210 394 210 395 396 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 1 1 2 2 2 2 2 2 1 1 2 2 2 1 1 2 1 1 2 2 2 2 2 2 2 2 2 2 2 1 1 2 1 1 2 2 2 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 2 1 1 1 1 84 48 85 95 211 1 1 86 49 89 94 214 1 1 91 50 96 93 223 2 1 98 51 99 108 229 1 1 102 53 110 97 236 2 1 103 52 105 113 238 1 1 107 57 111 106 240 2 1 115 54 121 132 248 1 1 119 56 120 136 257 1 1 128 60 141 125 269 2 1 131 58 143 144 276 1 1 135 62 142 133 278 2 1 142 21 135 148 288 1 1 146 59 153 155 296 1 1 149 65 156 147 302 2 1 151 63 157 161 306 1 1 154 67 163 152 310 2 1 156 25 149 169 311 1 1 157 27 151 171 313 1 1 158 66 165 164 314 2 1 162 70 172 160 316 2 1 166 69 173 174 323 1 1 167 71 168 170 324 1 1 179 72 175 185 349 1 1 184 78 188 182 352 2 1 186 74 190 191 357 1 1 187 79 192 189 358 2 1 188 39 184 194 359 1 1 192 41 187 199 368 1 1 193 76 196 200 369 1 1 1 5 255 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 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14.6503 2.8479 2 2.2298 3.2204 14.4299 15.7247 17.4785 16.3906 4.55 4.8807 3.0334 18.47 14.2196 4.4472 17.1032 15.5907 18.708 4.1625 3.4501 17.3696 16.0775 15.7225 16.2189 3.5988 17.226 17.3169 19.1922 13.9886 14.9611 19.6682 13.7757 3.0166 2.8863 15.258 5.1063 16.8177 20.1523 17.062 14.9318 4.0323 2.6017 20.3903 6.1941 13.5733 17.9829 15.0652 15.0725 7.1767 6.8083 12.6015 18.7809 12.4338 13.079 13.5022 16.8778 7.5782 16.4594 6.9759 13.0124 13.1714 10.391 12.1187 8.4086 12.5585 8.4838 17.1359 11.3286 10.2234 10.803 14.2018 14.4237 12.5953 15.0836 13.8234 7.7385 10.1511 10.2393 13.0637 6.3736 18.1119 10.4818 12.9367 6.7885 7.3112 13.77 9.8299 13.5678 12.8354 8.4164 10.8939 12.8824 11.8315 8.5841 9.1864 10.7263 12.7166 11.9091 7.8141 11.7244 13.2095 9.5087 11.4962 12.7012 13.0599 11.3363 6.8765 12.7599 12.833 10.3441 11.9404 9.956 11.5523 10.5601 16.8058 16.2316 17.0968 14.9866 17.3431 16.492 17.8264 17.9198 16.7932 17.0496 16.7807 16.1094 16.4978 15.239 14.5678 16.4655 16.823 17.5259 2.1484 1.7338 1.4152 1.6148 2.2438 3.1046 3.814 14.62 16.3931 16.3135 16.5847 4.3686 13.8898 13.6453 4.3858 5.0441 16.501 14.1553 4.4472 3.6038 3.7996 17.4959 17.9766 15.4887 15.8834 16.6663 17.2433 17.8147 15.1573 16.4057 15.649 3.3301 6.2675 17.846 17.2933 17.4917 17.9261 19.0446 15.8434 19.8157 13.0258 2.4579 2.7479 3.5753 3.3984 2.5368 2.3742 14.788 20.6001 17.9056 4.591 4.301 3.4736 2.555 1.9834 2.6483 20.9856 13.6082 13.8649 18.5538 5.7496 15.0063 14.795 14.0855 7.7886 7.1842 14.1922 6.39 17.6996 14.1607 18.4073 19.2757 19.1545 13.2064 14.7065 13.4216 13.0649 13.6598 7.8915 7.1057 7.0454 17.0509 13.271 18.6767 12.9664 9.6729 11.0189 7.877 16.6133 17.3738 10.9379 16.2817 10.8433 10.3347 10.688 14.3126 5.6247 14.1266 14.3951 13.1588 12.3367 12.0318 11.9937 14.2935 14.2276 13.3532 9.0486 7.4456 8.2258 9.7583 9.6105 12.8521 13.5472 5.7536 6.2622 14.3667 11.9837 13.8451 10.8746 11.0224 12.1445 9.4371 9.2893 13.3727 11.5218 19.3935 18.6026 7.0015 7.9391 10.097 12.4574 6.1701 5.4541 8.8908 9.168 12.1643 10.7699 13.0155 10.2279 10.6223 12.1452 12.0514 11.3057 11.7668 7.5009 8.2866 11.7551 11.1199 11.8919 11.9736 11.1006 12.7453 12.4448 13.5448 9.6848 12.1012 9.4352 10.4487 12.1638 13.3578 12.4011 8.1218 9.9696 12.5555 5.5253 9.3408 11.9268 10.3194 1.7034 -1.1972 6.5507 -1.2518 1.5617 7.1888 0.6169 1.6342 -0.4407 2.9691 4.5348 5.5893 -1.3676 4.6384 2.9505 3.354 7.5642 4.5268 7.1678 0.8024 4.611 -2.3077 2.5499 0.9964 4.8963 4.9268 -1.5186 7.6612 0.5618 -3.9612 6.1456 -1.7415 -0.6746 0.8875 -0.3749 3.9409 -2.1105 1.4144 -2.7681 3.188 4.2313 3.5932 -1.5446 0.3727 0.0549 1.6788 -0.6698 0.3009 1.9307 0.9541 3.3028 -0.3415 2.0082 5.2682 3.1217 5.0126 2.5044 -0.8693 5.9296 2.8975 6.6401 2.2643 -2.8332 0.4315 4.5216 6.3713 -0.2956 4.6364 -2.3266 -1.651 -1.2377 1.5641 -0.8031 2.317 -2.0204 0.8096 -5.8058 -0.9643 2.2596 0.1493 -7.5078 -0.4756 -6.3787 0.0802 -0.6213 1.343 0.8339 0.0331 1.9307 2.8818 0.7418 2.8818 0.5228 1.1557 -0.1352 0.7092 1.9861 3.9548 3.4359 2.4688 2.3867 2.0121 -0.5349 1.5585 -1.2809 3.6336 2.6898 4.9374 1.6293 2.9898 1.7887 2.479 -0.7119 2.6005 6.2508 1.7135 -1.0772 -2.2306 5.7341 6.6356 7.0768 6.4236 5.3985 0.9375 1.9746 3.6607 2.8801 1.9117 0.8123 2.5394 -1.0042 6.5815 4.1619 1.217 3.2287 6.2867 7.978 7.0016 2.1883 1.5607 1.8207 3.6185 -1.1142 -1.9868 1.3752 6.2604 3.188 3.0159 4.1739 6.7748 -2.6478 1.3216 6.8984 0.4524 5.2745 4.9895 -1.704 5.8552 6.6836 -0.0019 -2.9785 -0.9991 -0.2841 5.5075 6.8411 -2.4018 -1.2723 -1.277 5.8984 -0.8812 -0.9458 -1.6658 -3.1601 -1.5758 1.3984 3.6505 -0.0666 -4.1038 1.2164 -1.3537 3.3028 -1.174 -4.8621 -1.0823 1.0189 1.9692 2.8977 -1.8105 2.5499 0.9834 2.6073 3.8835 0.5922 -1.5809 0.3453 0.4675 -0.822 -6.5641 4.5216 0.3708 -0.6581 -0.4541 0.693 -0.0682 -0.2778 -0.5788 -1.251 -1.5004 -2.1726 -2.2973 -0.0682 -1.051 -1.0789 0.8433 1.1912 1.3495 -0.445 0.4156 1.3938 2.1829 3.0107 3.4984 1.0341 3.4984 3.0107 1.1749 0.1025 0.4783 4.4376 3.9959 3.23 2.3897 1.8489 1.7776 2.2074 2.6022 -0.6086 -0.729 -0.6921 2.3403 3.5148 2.7561 1.1717 1.621 2.6266 2.626 4.864 6.5196 1.2014 -1.6842 -0.9509 -2.0365 -2.8194 -2.4247 -0.4702 3.7399 5.0992 7.2268 6.8797 6.518 2.9745 6.4173 7.04 4.8036 5.5138 0.3353 -1.3351 3.4822 2.3118 1.081 0.2536 0.5435 2.8889 3.0515 2.1899 -0.2959 0.7882 3.1243 7.7092 8.5367 8.2467 7.6198 6.9549 6.3833 2.3616 2.4397 1.2736 3.8602 5.3204 -1.7314 -0.5561 3.2931 1.4756 1.9952 7.2396 7.0003 2.2047 4.8285 2.5211 2.6423 3.5107 4.5284 -3.4122 7.2916 6.155 -1.8125 7.4335 7.2999 0.0182 0.2666 4.426 4.8526 -1.1189 5.4004 4.126 -1.126 -0.6179 -0.8567 6.9304 -0.7408 6.8373 7.451 -3.011 -2.115 4.852 -1.8211 -0.6576 6.157 6.4619 5.6398 -1.7376 -1.35 -0.4756 -0.5416 -2.2401 -2.2123 -2.0491 -2.6804 -3.4636 1.9812 1.0103 3.6543 3.0406 5.402 -0.9335 -1.8423 -4.5835 -3.8003 0.9083 -4.3824 -5.1656 -1.9096 1.1685 -0.6682 -1.3946 1.9213 1.5736 3.1933 -2.2619 -2.6273 -1.8269 0.4445 1.1919 0.9759 -5.9208 -1.4659 1.6484 4.4948 0.8328 -0.9775 -1.4386 -2.1844 -0.1898 -0.0562 1.0868 0.6053 4.0443 4.9173 4.999 -3.2196 -0.7364 -0.2718 4.8425 0.0671 -7.978 -7.6228 0.1021 0.096 -0.7932 -6.8488 -0.0847 -1.1737 0.2705 -1.5777 -2.6667 -2.8687 8 8 6 6 5 6 5 5 8 8 5 8 8 8 5 5 8 8 5 5 8 5 6 6 6 5 6 5 6 5 5 5 5 6 5 6 6 6 6 6 8 8 8 8 8 8 55 55 84 86 91 98 102 103 104 104 107 109 109 114 115 119 124 127 128 131 134 135 142 146 149 151 154 156 157 158 162 166 167 179 184 186 187 188 192 193 202 202 206 207 208 209 112 114 211 214 96 229 110 105 109 112 111 114 124 127 121 257 134 139 269 276 139 278 21 296 302 306 163 25 27 314 172 173 324 349 352 190 358 39 41 196 206 207 208 209 210 210 0 Compound Canonicalized 5 2011.04.04 0 Compound Complexity 7 E_COMPLEXITY 3.396 Cactvs xemistry.com 2012.02.08 7300 Count Hydrogen Bond Acceptor 5 E_NHACCEPTORS 3.396 Cactvs xemistry.com 2012.02.08 48 Count Hydrogen Bond Donor 5 E_NHDONORS 3.396 Cactvs xemistry.com 2012.02.08 39 Count Rotatable Bond 5 E_NROTBONDS 3.396 Cactvs xemistry.com 2012.02.08 27 Fingerprint SubStructure Keys 16 extended 2 E_SCREEN 3.396 Cactvs xemistry.com 2012.02.08 00000371F07FFE00700000000000000000000000000162C58B1630600000000000005801F400001E04100800000D3CE5DE06BFC8F3C99200A80335F77C00828020B1022009D9A1B864988A70FEC0D9B194600866B602D8C807BF9FC28E80000000000200000000000000040000000000000000 InChI Standard 1 1.0.4 InChI iupac.org 2012.02.08 InChI=1S/C127H186N36O41S6/c1-56(2)38-73-123(201)161-35-20-29-84(161)115(193)154-95(57(3)4)117(195)148-76-50-205-206-51-77-111(189)157-100(62(10)167)122(200)152-80-54-209-207-52-78(151-121(199)99(61(9)166)156-106(184)69(31-32-93(176)177)139-89(172)47-137-104(76)182)108(186)143-70(39-64-22-13-12-14-23-64)102(180)135-45-88(171)134-46-92(175)153-97(59(7)164)119(197)150-79(109(187)145-72(42-87(129)170)107(185)159-101(63(11)168)126(204)163-37-18-27-82(163)113(191)138-49-91(174)141-77)53-208-210-55-81(112(190)158-98(60(8)165)120(198)142-68(26-17-33-132-127(130)131)105(183)144-71(41-86(128)169)103(181)136-48-90(173)140-73)149-118(196)96(58(5)6)155-116(194)85-30-21-36-162(85)124(202)74(40-65-44-133-67-25-16-15-24-66(65)67)147-114(192)83-28-19-34-160(83)125(203)75(43-94(178)179)146-110(80)188/h12-16,22-25,44,56-63,68-85,95-101,133,164-168H,17-21,26-43,45-55H2,1-11H3,(H2,128,169)(H2,129,170)(H,134,171)(H,135,180)(H,136,181)(H,137,182)(H,138,191)(H,139,172)(H,140,173)(H,141,174)(H,142,198)(H,143,186)(H,144,183)(H,145,187)(H,146,188)(H,147,192)(H,148,195)(H,149,196)(H,150,197)(H,151,199)(H,152,200)(H,153,175)(H,154,193)(H,155,194)(H,156,184)(H,157,189)(H,158,190)(H,159,185)(H,176,177)(H,178,179)(H4,130,131,132)/t59-,60-,61-,62-,63-,68+,69+,70+,71+,72+,73+,74+,75+,76+,77+,78+,79+,80+,81+,82+,83+,84+,85+,95+,96+,97+,98+,99+,100+,101+/m1/s1 InChIKey Standard 1 1.0.4 InChI iupac.org 2012.02.08 FGHWTXMNNRWBCE-PEYIALSASA-N Log P XLogP3-AA 7 3.0 sioc-ccbg.ac.cn 2012.02.08 -8.2 Mass Exact 7 2.1 PubChem ncbi.nlm.nih.gov 2012.02.08 3064.1934 Molecular Formula 1 2.1 PubChem ncbi.nlm.nih.gov 2012.02.08 C127H186N36O41S6 Molecular Weight 7 2.1 PubChem ncbi.nlm.nih.gov 2012.02.08 3065.44234 SMILES Canonical 1 1.7.6 OEChem openeye.com 2012.02.08 CC(C)CC1C(=O)N2CCCC2C(=O)NC(C(=O)NC3CSSCC4C(=O)NC(C(=O)NC5CSSCC(C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)N1)CC(=O)N)CCCNC(=N)N)C(C)O)NC(=O)C(NC(=O)C6CCCN6C(=O)C(NC(=O)C7CCCN7C(=O)C(NC5=O)CC(=O)O)CC8=CNC9=CC=CC=C98)C(C)C)C(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)NCC(=O)N4)C(C)O)CC(=O)N)C(C)O)CC1=CC=CC=C1)NC(=O)C(NC(=O)C(NC(=O)CNC3=O)CCC(=O)O)C(C)O)C(C)O)C(C)C SMILES Isomeric 1 1.7.6 OEChem openeye.com 2012.02.08 C[C@H]([C@H]1C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N4CCC[C@H]4C(=O)N[C@H](C(=O)N[C@H]5CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N1)CC6=CC=CC=C6)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC5=O)CCC(=O)O)[C@@H](C)O)C(=O)N[C@H](C(=O)N7CCC[C@H]7C(=O)N[C@H](C(=O)N8CCC[C@H]8C(=O)N[C@H](C(=O)N3)C(C)C)CC9=CNC1=CC=CC=C19)CC(=O)O)[C@@H](C)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC2=O)CC(=O)N)[C@@H](C)O)C(C)C)CC(C)C)CC(=O)N)CCCNC(=N)N)[C@@H](C)O)O Topological Polar Surface Area 7 E_TPSA 3.396 Cactvs xemistry.com 2012.02.08 1330 Weight MonoIsotopic 7 2.1 PubChem ncbi.nlm.nih.gov 2012.02.08 3063.190046 210 30 30 0 0 0 0 0 1 1000