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Compound Summary for: CID 5284616


Also known as: rapamycin; Rapamune; 53123-88-9; (-)-Rapamycin; AY-22989; WY-090217; CHEBI:9168; NCGC00021305-05; Antibiotic AY 22989
Molecular Formula: C51H79NO13   Molecular Weight: 914.17186   InChIKey: QFJCIRLUMZQUOT-HPLJOQBZSA-N
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.   From: MeSH
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Use and Manufacturing
Biomedical Effects and Toxicity
Safety and Handling
Environmental Fate and Exposure Potential
Exposure Standards and Regulations
Biomolecular Interactions and Pathways
Biological Test Results
Chemical and Physical Properties
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