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Compound Summary for: CID 457964

Aphidicolin

Also known as: ICI 69653, NSC234714, CHEBI:2766, Aphidicolin from Nigrospora sphaerica, 38966-21-1
Molecular Formula: C20H34O4   Molecular Weight: 338.48156   InChIKey: NOFOAYPPHIUXJR-APNQCZIXSA-N
An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.   From: MeSH
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