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Compound Summary for: CID 456199

PA-824

Also known as: PA 824; Pretomanid; PA824; 187235-37-6; UNII-2XOI31YC4N; CHEMBL227875; (S)-PA 824; AC1L9UFX; Pretomanid [USAN:INN]
Molecular Formula: C14H12F3N3O5   Molecular Weight: 359.25739   InChIKey: ZLHZLMOSPGACSZ-NSHDSACASA-N
PA-824 is a nitroimidazole, a class of novel anti-bacterial agents. As a potential TB therapy, it has many attractive characteristics - most notably its novel mechanism of action, its activity in vitro against all tested drug-resistant clinical isolates, and its activity as both a potent bactericidal and a sterilizing agent in mice. In addition, the compound shows no evidence of mutagenicity in a standard battery of genotoxicity studies, no significant cytochrome P450 interactions, and no significant activity against a broad range of Gram-positive and Gram-negative bacteria.   From: DrugBank
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