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Compound Summary for: CID 39484

1-Methyl-4-phenylpyridinium

Also known as: Cyperquat, N-Methyl-4-phenylpyridine, MPP+, Cyperquat [ANSI], N-Methyl-4-phenylpyridinium ion, Pyridinium, 1-methyl-4-phenyl-, CHEBI:641
Molecular Formula: C12H12N+   Molecular Weight: 170.23038   InChIKey: FMGYKKMPNATWHP-UHFFFAOYSA-N
An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.   From: MeSH
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