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Compound Summary for: CID 300471

elesclomol

Also known as: STA-4783; 488832-69-5; STA 4783; N'1,N'3-dimethyl-N'1,N'3-bis(phenylcarbonothioyl)propanedihydrazide; STA4783; Elesclomol (USAN); NSC174939
Molecular Formula: C19H20N4O2S2   Molecular Weight: 400.5177   InChIKey: BKJIXTWSNXCKJH-UHFFFAOYSA-N
Elesclomol is a novel, injectable, drug candidate that kills cancer cells by elevating oxidative stress levels beyond a breaking point, triggering programmed cell death. In preclinical models elesclomol showed potent killing of a broad range of cancer cell types at high doses, and an ability to strongly enhance the efficacy of certain chemotherapy agents, with minimal additional toxicity, at moderate doses. It is being developed by Synta Pharmaceuticals.   From: DrugBank
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