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Compound Summary for: CID 21195079

Glucarpidase

Also known as: Conjugase; Voraxaze; Folyl conjugase; Folate conjugase; Folate hydrolase; Voraxaze\r\n; Carboxypeptidase G; NAALADase
Molecular Formula: Zn4+8   Molecular Weight: 261.52   InChIKey: LZQXMCNBQHANEY-UHFFFAOYSA-N
Glucarpidase is the recombinant form of the enzyme carboxypeptidase that is produced in Esherichia coli. In patients, glucarpidase inactivates methotrexate, and other antifolates, by hydrolyzing glutamate on the carboxyl terminal of these compounds. Therefore since methotrexate is elminated enzymatically and not by the kidneys, glucarpidase is indicated in patients on methotrexate treatment who have kidney dysfunction, and are experiencing an abnormally high plasma concentration of methotrexate (>1 micromole per liter). Glucarpidase is marketed under the brand name Voraxaze®.   From: DrugBank
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