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Compound Summary for: CID 1986

Acetazolamide

Also known as: Diamox; Diacarb; Glaupax; Defiltran; Diluran; Edemox; Acetazolamid; Diuramid; Glupax
Molecular Formula: C4H6N4O3S2   Molecular Weight: 222.24544   InChIKey: BZKPWHYZMXOIDC-UHFFFAOYSA-N
One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)   From: MeSH
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